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Influence of pepsinogen gene polymorphisms on serum pepsinogen

Published online by Cambridge University Press:  01 March 1997

Z. YAMAGATA ,
Y. ZHANG ,
S. SHINOZAKI ,
T. MIYAMURA ,
S. IIJIMA ,
A. ASAKA  and
K. KOBAYASHI
Z. YAMAGATA
Affiliation:
Health Care Center, Yamanashi University, Japan
Y. ZHANG
Affiliation:
Department of Health Sciences, Yamanashi Medical University, Japan
S. SHINOZAKI
Affiliation:
Department of Health Sciences, Yamanashi Medical University, Japan
T. MIYAMURA
Affiliation:
Department of Health Sciences, Yamanashi Medical University, Japan
S. IIJIMA
Affiliation:
Department of Health Sciences, Yamanashi Medical University, Japan
A. ASAKA
Affiliation:
Department of Health Sciences, Yamanashi Medical University, Japan
K. KOBAYASHI
Affiliation:
Yamanashiken Koseiren Health Screening Center, Japan
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Abstract

We identified pepsinogen C (PGC) gene polymorphisms by means of PCR, which amplified DNA in the region within the intron between exons 7 and 8, and by 6% polyacrylamide gel electrophoresis. Six alleles were found in a Japanese population. The frequencies of these alleles in 408 unrelated Japanese individuals were 0·074, 0·026, 0·335, 0·237, 0·016 and 0·314, respectively. The serum pepsinogen II level significantly decreased in the order of the allele 6 homozygote, the allele 6 heterozygote and the other genotypes (χ2=7·850, D.F.=2, p=0·020). These findings indicated that the genetic background of serum pepsinogen should be considered when screening for stomach cancer by this procedure.

Type
Research Article
Information
Annals of Human Genetics , Volume 61 , Issue 2 , March 1997 , pp. 93 - 97
Copyright
© University College London 1997

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