Hostname: page-component-669899f699-vbsjw Total loading time: 0 Render date: 2025-04-24T10:43:32.621Z Has data issue: false hasContentIssue false
  • English
  • Français

A CORRECTION TO TDT STATISTICS FOR MAPPING QUANTITATIVE TRAIT LOCI

Published online by Cambridge University Press:  01 September 1999

J. Wang  and
J. Cohen
J. Wang
Affiliation:
Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235-9052, USA. Tel: 214-648-8734; Fax: 214-648-7150; E-mail: [email protected]
J. Cohen
Affiliation:
Center for Human Nutrition, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75235-9052, USA. Tel: 214-648-8734; Fax: 214-648-7150; E-mail: [email protected]
Get access

Abstract

Xiong et al. (1998) proposed a general transmission disequilibrium test (TDT) for quantitative traits. Their TDT for quantitative traits permits more than one child and more than one heterozygous parent per family. This TDT is also appropriate for the situation where the trait and marker loci are at varying degrees of linkage and linkage disequilibrium. Their generalized TDT statistic for a multi-allele marker locus may be more useful in practice. However, there are several mistakes in their mathematical presentation for this generalized TDT statistic for a multi-allele marker locus, and it confuses readers. Here, we present a corrected TDT statistic for a multi-allele marker locus with a clearer presentation. We hope that this new presentation will remove some confusion for readers.

Type
Letter to the Editor
Information
Annals of Human Genetics , Volume 63 , Issue 5 , September 1999 , pp. 469
Copyright
© University College London 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

This communication has been seen by Dr Xiong and accepted as an appropriate correction to the paper published in 1998 (Ann. Hum. Genet.62, 431–452).