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An immunogenetic map of Lombardy (Northern Italy)

Published online by Cambridge University Press:  25 April 2002

M. MARTINETTI ,
A. DEGIOANNI ,
A. M. D'ARONZO ,
E. BENAZZI ,
R. CARPANELLI ,
L. CASTELLANI ,
S. CENZUALES ,
U. DE BIASE ,
C. DE FILIPPO  and
A. DE GIULI
...Show all authors
M. MARTINETTI
Affiliation:
Lab. HLA, Serv. Immunoematol. Trasf.-IRCCS Policlinico S. Matteo-Pavia, Italy
A. DEGIOANNI
Affiliation:
Lab. HLA, Serv. Immunoematol. Trasf.-IRCCS Policlinico S. Matteo-Pavia, Italy
A. M. D'ARONZO
Affiliation:
Lab. HLA, Serv. Immunoematol. Trasf.-IRCCS Policlinico S. Matteo-Pavia, Italy
E. BENAZZI
Affiliation:
Serv. Ematol-IRCCS Ospedale S. Raffaele-Milano, Italy
R. CARPANELLI
Affiliation:
Serv. Immunoematol. Trasf.-Azienda Istituti Ospitalieri-Cremona, Italy
L. CASTELLANI
Affiliation:
Lab. Immunol. Serv. Immunoematol. Trasf-Bergamo, Italy
S. CENZUALES
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale Sacco-Milano, Italy
U. DE BIASE
Affiliation:
Lab. Analisi-Ospedale Carlo Poma-Mantova, Italy
C. DE FILIPPO
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale Civile S. Antonio-Gallarate, Italy
A. DE GIULI
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale Maggiore-Lodi, Italy
A. GEROSA
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale-Lecco, Italy
M. FARÈ
Affiliation:
Serv. Immunoematol. Trasf.-Istituto Ortopedico Pini-Milano, Italy
G. FERRIOLI
Affiliation:
Serv. Immunoematol. Trasf.-Osp. Niguarda Cà Granda-Milano, Italy
G. GALVANI
Affiliation:
Lab. Analisi., Ospedale Fatebenefratelli-Erba, Italy
C. LOMBARDO
Affiliation:
Serv. Immunoematol. Trasf.-Istituto Tumori-Milano, Italy
A. MALAGOLI
Affiliation:
Serv. Immunol. Clin. Allergol.-Spedali Civili-Brescia, Italy
S. MARCHESI
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale S. Carlo-Milano, Italy
L. MASCARETTI
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale S. Gerardo-Monza, Italy
F. MOTTA
Affiliation:
Lab. Ematol., Serv. Immunoematol. Trasf.-Presidio Ospedaliero G. Fornaroli-Magenta, Italy
V. SIOLI
Affiliation:
Immunol. Trapianti, Ospedale Maggiore Policlinico-Milano, Italy
C. RINALDINI
Affiliation:
Serv. Immunoematol.-Trasf.-Ospedale Multizonale-Varese, Italy
L. RIZZOLO
Affiliation:
Serv. Immunoematol. Trasf.-Ospedale Fatebenefratelli-Milano, Italy
C. PASCUTTO
Affiliation:
Dip. Sci. Sanit. Appl. e Psicocomportam., Università-Pavia, Italy
L. BERNARDINELLI
Affiliation:
Dip. Sci. Sanit. Appl. e Psicocomportam., Università-Pavia, Italy
L. SALVANESCHI
Affiliation:
Lab. HLA, Serv. Immunoematol. Trasf.-IRCCS Policlinico S. Matteo-Pavia, Italy
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Abstract

For this study we consulted the Bone Marrow Donors' Registry of Lombardy (Italy) and analyzed 43937 HLA-A,B phenotypes and 13922 HLA-A,B,DR phenotypes. We estimated the HLA-A,B and HLA-A,B,DR haplotype frequencies via the maximum-likelihood method. We analyzed the genetic structure of the 11 provinces of Lombardy by means of Principal Component Analysis and Correspondence Analysis, and estimated the variety of the different haplotypes at provincial level and the percentage of unique phenotypes at village level. We found 11189 different HLA-A,B phenotypes, 661 different HLA-A,B haplotypes and more than 4000 different HLA-A,B,DR haplotypes. We identified 20 villages, in Western Lombardy, very rich in unique/rare phenotypes. Here we report a formula which allows the identification of a putative donor matched for two haplotypes with a recipient. This result may be of great importance for the genetic study of the population of Lombardy and, even more, for bone marrow transplantation programs.

Type
Research Article
Information
Annals of Human Genetics , Volume 66 , Issue 1 , January 2002 , pp. 37 - 48
Copyright
© University College London 2002

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