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Potential role of sirtuins in livestock production

Published online by Cambridge University Press:  08 June 2012

Y. Ghinis-Hozumi ,
A. Antaramian ,
F. Villarroya ,
E. Piña  and
O. Mora
Y. Ghinis-Hozumi
Affiliation:
Programa de Posgrado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, México
A. Antaramian
Affiliation:
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Querétaro, Qro. 76230, México
F. Villarroya
Affiliation:
Departamento de Bioquímica y Biología Molecular e Instituto de Biomedicina (IBUB), Universitat de Barcelona y Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Avenida Diagonal 645, Barcelona 08028, Spain
E. Piña
Affiliation:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, México
O. Mora*
Affiliation:
Laboratorio de Rumiología y Metabolismo Nutricional (RuMeN), Secretaría de Posgrado, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Boulevard Bernardo Quintana 514-D, Colonia Arboledas, Querétaro, Qro. 76140, México
*
†E-mail: [email protected] or [email protected]
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Abstract

Sirtuins are NAD+-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate energy homeostasis as they can sense the metabolic state of the cell through the NAD+/NADH ratio; hence, changes in the diet can modify the expression of these enzymes. Dietary manipulations are a common practice currently being used in livestock production with favorable results, probably due in part to the enhanced activity of sirtuins. Nevertheless, sirtuin expression in livestock species has not been a research target. For these reasons, the goal of this review is to awaken interest in these enzymes for future detailed characterization in livestock species by presenting a general introduction to what sirtuins are, how they work and what is known about their role in livestock.

Keywords

energylivestockmetabolismproductionsirtuin
Type
Physiology and functional biology of systems
Information
animal , Volume 7 , Issue 1 , January 2013 , pp. 101 - 108
Copyright
Copyright © The Animal Consortium 2012

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