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Overall assessment of antimicrobial peptides in piglets: a set of meta-analyses

Published online by Cambridge University Press:  08 July 2020

B. C. Xu ,
J. Fu ,
L. Y. Zhu ,
Z. Li ,
Y. Z. Wang  and
M. L. Jin Open the ORCID record for M. L. Jin [Opens in a new window]
B. C. Xu
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
J. Fu
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
L. Y. Zhu
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
Z. Li
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
Y. Z. Wang
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
M. L. Jin*
Affiliation:
Key laboratory of Molecular Animal Nutrition, Ministry of Education, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Key Laboratory of Animal Nutrition and Feed Science of Zhejiang Province, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China Institute of Feed Science, College of Animal Science, Zhejiang University, 866 Yuhang Tang Road, Hangzhou, Zhejiang310058, P.R. China
*
†E-mail: [email protected]
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Abstract

Developing alternatives to antibiotics is an urgent need in livestock production. Antimicrobial peptides (AMPs) are regarded as powerful antibiotic substitutes (ASs) because AMPs have broad-spectrum antimicrobial activities and growth-promoting ability. Here, we aimed to comprehensively assess the effects of AMPs on the growth performance, diarrhea rate, intestinal morphology and immunity of healthy or challenged piglets, compared with an antibiotics group or negative control group. We performed a set of meta-analyses of feeding trials from database inception to 27 May 2019. Among the 1379 identified studies, 20 were included in our meta-analyses (56 arms and 4067 piglets). The meta-analyses revealed that (1) compared with the negative control group, AMPs significantly improved the healthy piglets’ average daily gain (ADG), average daily feed intake (ADFI), gain : feed ratio (G/F), levels of immune globulin (Ig) IgM and IgG, and intestinal villus height : crypt depth ratio (V/C) (P < 0.05). Meanwhile, AMPs significantly increased the challenged piglets’ ADG, ADFI, G/F and V/C of the jejunum and ileum, and notably deceased the diarrhea rate (P < 0.05); (2) compared with antibiotics group, the effects of AMPs were slightly weaker than those of antibiotics in the healthy piglets, but AMPs have similar effects to those of antibiotics in challenged piglets. In a higher purity, the optimal dose of AMPs may be approximately 0.01%. Our findings indicate that AMPs can improve piglet growth performance, enhance immunity, benefit intestinal morphology and decrease the diarrheal rate. AMPs could be great ASs especially under infection conditions.

Keywords

antimicrobial peptidesantibiotic substitutemeta-analysispigbacteria challenge
Type
Research Article
Information
animal , Volume 14 , Issue 12 , December 2020 , pp. 2463 - 2471
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Animal Consortium

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