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Meta-analysis of the effect of immunocastration on production performance, reproductive organs and boar taint compounds in pigs

Published online by Cambridge University Press:  10 February 2012

N. Batorek ,
M. Čandek-Potokar ,
M. Bonneau  and
J. Van Milgen
N. Batorek
Affiliation:
Agricultural Institute of Slovenia, Hacquetova 17, 1000 Ljubljana, Slovenia
M. Čandek-Potokar*
Affiliation:
Agricultural Institute of Slovenia, Hacquetova 17, 1000 Ljubljana, Slovenia Faculty of Agriculture and Life Sciences, University of Maribor, Pivola 10, 2311 Hoče, Slovenia
M. Bonneau
Affiliation:
INRA, UMR 1348 PEGASE, 35590 Saint Gilles, France Agrocampus-Ouest, 35000 Rennes, France
J. Van Milgen
Affiliation:
INRA, UMR 1348 PEGASE, 35590 Saint Gilles, France Agrocampus-Ouest, 35000 Rennes, France
*
†E-mail: [email protected]
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Abstract

Meta-analytical approach was used to quantitatively synthesize the effect of immunocastration on growth, carcass, meat quality, reproductive organs and boar taint compounds. Altogether, 41 papers were collected for effect size (θ) calculation and the comparisons were made with entire males (EM) and surgical castrates (SC). The data for reproductive organs and growth performance are numerous enough to draw firm conclusions. In contrast, data for carcass and meat quality are more limited. Results of meta-analysis show efficient immunocastration with the magnitude of the response being by far the largest for reproductive organs (θ = −2.8 to −5.0) and boar taint substances (θ = −2.8 and −0.8 for androstenone and skatole, respectively). However, compared with SC, the immunocastrates exhibit larger bulbourethral glands (θ = 1.3) and slightly higher concentrations of androstenone and skatole (θ = 0.1 and θ = 0.2, respectively). The impact of immunocastration is also remarkable on performance, where the main advantage of the immunocastrates is their boar-like performance until revaccination. In the period following the second vaccination, they eat much more than EM (θ = 2.1), resulting in large effect size for growth rate compared with both EM and SC (θ = 1.1 and θ = 1.4, respectively). Considering the whole fattening period, their feed conversion ratio is higher compared with EM (θ = 0.6) and much lower than that of SC (θ = −1.3), although exhibiting moderately faster growth compared with both (θ = 0.6 and θ = 0.2, respectively). With regard to carcass quality, the immunocastrates take intermediate position between EM and SC. Besides, our analysis suggests no difference in meat quality with SC and some meat quality advantages of immunocastrates over EM because of higher intramuscular fat content (θ = 0.4) and lower shear force (θ = −0.6).

Keywords

meta-analysisimmunocastrationperformanceboar taintpigs
Type
Full Paper
Information
animal , Volume 6 , Issue 8 , August 2012 , pp. 1330 - 1338
Copyright
Copyright © The Animal Consortium 2012

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References

Andrews, S, Lohner, E, Schrade, H, Horst, I 2009. The effect of vaccinating male pigs with Improvac on growth performance and carcase quality. 55th International Congress of Meat Science and Technology, Copenhagen, Denmark, August 16–21, PE1.03.Google Scholar
Awoniyi, CA, Chandrashekar, V, Arthur, RD, Schanbacher, BD, Amador, AG, Falvo, RE 1988. Pituitary and Leydig cell function in boars actively immunized against gonadotropin-releasing hormone. Journals of Reproduction & Fertility 84, 295–302.CrossRefGoogle Scholar
Babol, J, Squires, J 1995. Quality of meat from entire male pigs. Food Research International 28, 201–212.CrossRefGoogle Scholar
Bauer, A, Lacorn, M, Danowski, K, Claus, R 2008. Effects of immunization against GnRH on gonadotropins, the GH-IGF-1-axis and metabolic parameters in barrows. Animal 2, 1215–1222.CrossRefGoogle Scholar
Bonneau, M 2010. Accessory sex glands as a tool to measure the efficacy of immunocastration in male pigs. Animal 4, 930–932.CrossRefGoogle ScholarPubMed
Bonneau, M, Meusy-Dessolle, N, Léglise, PC, Claus, R 1982. Relationships between fat and plasma androstenone and plasma testosterone in fatty and lean young boars following castration. Acta Endocrinologica (Copenhagen) 101, 129–133.Google ScholarPubMed
Bonneau, M, Dufour, R, Chouvet, C, Roulet, C, Meadus, W, Squires, EJ 1994. The effects of immunization against luteinizing hormone-releasing hormone on performance, sexual development, and levels of boar taint-related compounds in intact male pigs. Journal of Animal Science 72, 14–20.CrossRefGoogle ScholarPubMed
Borenstein, M, Hedges, L, Rothstein, H 2007. Meta-analysis. Fixed effects vs. random effects. www.Meta-Analysis.com © Borenstein, Hedges, Rothstein, 162 pp.Google Scholar
Brunius, C, Zamaratskaia, G, Andersson, K, Chen, G, Norrby, M, Madej, A, Lundström, K 2011. Early immunocastration of male pigs with Improvac® – effect on boar taint,hormones and reproductive organs. Vaccine 29, 9514–9520.CrossRefGoogle ScholarPubMed
Caraty, A, Bonneau, M 1986. Immunisation active du porc mâle contre la gonadolibérine: effets sur la secrétion d'hormones gonadotropes et sur la teneur en 5a-androst-16-ène-3-one du tissu adipeux. Comptes Rendus des Séances de l'Académie des Sciences de Paris, Série D 303, 673–676.Google Scholar
Claus, R 1976. Messung des Ebergeruchstoffes im Fett von Schweinen mittels eines Radioimmunotest. 2. Mitteilung: Zeitlicher Verlauf des Ebergeruchdepotabbaues nach der Kastration. Zeitschrift für Tierzucht und Züchtungsbiologie 93, 38–47.CrossRefGoogle Scholar
Claus, R, Weiler, U 1987. Umwelteinflüsse auf das geschlechtsspezifische Wachstumsvermögen. Übersicht zur Tierernahrung 15, 301–316.Google Scholar
Claus, R, Lacorn, M, Danowski, K, Pearce, MC, Bauer, A 2007. Short-term endocrine and metabolic reactions before and after second immunization against GnRH in boars. Vaccine 25, 4689–4696.CrossRefGoogle ScholarPubMed
Cronin, GM, Dunshea, FR, Butler, KL, McCauley, I, Barnett, JL, Hemsworth, P 2003. The effects of immuno- and surgical-castration on the behaviour and consequently growth of group-housed, male finisher pigs. Applied Animal Behaviour Science 81, 111–126.CrossRefGoogle Scholar
D'Souza, DN, Mullan, BP 2003. The effect of genotype and castration method on the eating quality characteristics of pork from male pigs. Animal Science 77, 67–72.CrossRefGoogle Scholar
Dunshea, FR, Colantoni, C, Howard, K, McCauley, I, Jackson, P, Long, KA, Lopaticki, S, Nugent, EA, Simons, JA, Walker, J, Hennessy, DP 2001. Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. Journal of Animal Science 79, 2524–2535.CrossRefGoogle ScholarPubMed
Einarsson, S, Andersson, K, Wallgren, M, Lundström, K, Rodriguez-Martinez, H 2009. Short- and long-term effects of immunization against gonadotropin-releasing hormone, using Improvac™, on sexual maturity, reproductive organs and sperm morphology in male pigs. Theriogenology 71, 302–310.CrossRefGoogle Scholar
Einarsson, S, Brunius, C, Wallgren, M, Lundström, K, Andersson, K, Zamaratskaia, G, Rodriguez-Martinez, H 2011. Effects of early vaccination with Improvac® on the development and function of reproductive organs of male pigs. Animal Reproduction Science 127, 50–53.CrossRefGoogle ScholarPubMed
Fàbrega, E, Velarde, A, Cros, J, Gispert, M, Suárez, P, Tibau, J, Soler, J 2010. Effect of vaccination against gonadotrophin-releasing hormone, using Improvac®, on growth performance, body composition, behavior and acute phase proteins. Livestock Science 132, 53–59.CrossRefGoogle Scholar
Falvo, RE, Chandrashekar, V, Arthur, RD, Kuenstler, AR, Hasson, T, Awoniyi, C, Schanbacher, BD 1986. Effect of active immunization against LHRH or LH in boars – reproductive consequences and performance traits. Journal of Animal Science 63, 986–994.CrossRefGoogle ScholarPubMed
Fang, F, Li, H, Liu, Y, Zhang, Y, Tao, Y, Li, Y, Cao, H, Wang, L, Zhang, X 2010. Active immunization with recombinant GnRH fusion protein in boars reduces both testicular development and mRNA expression levels of GnRH receptor in pituitary. Animal Reproduction Science 119, 275–281.CrossRefGoogle ScholarPubMed
Font i Furnols, M, Gispert, M, Soler, J, Diaz, M, Garcia-Regueiro, JA, Diaz, I, Pearce, MC 2012. Effect of vaccination against gonadotrophin-releasing factor on growth performance, carcass, meat and fat quality of male Duroc pigs for dry cured ham production. Meat Science, doi: 10.1016/j.meatsci.2012.01.008, Published online by Elsevier 21 January 2012.CrossRefGoogle ScholarPubMed
Friis, C 1993. Distribution, metabolic fate and elimination of skatole in the pig. In Measurement and prevention of boar taint in entire male pigs (ed. M Bonneau) INRA Edition, Paris 113–115.Google Scholar
Fuchs, T, Nathues, H, Koehrmann, A, Andrews, S, Brock, F, Sudhaus, N, Klein, G, Beilage, EG 2009. A comparison of the carcase characteristics of pigs immunized with a ‘gonadotropin-releasing factor (GnRF)’ vaccine against boar taint with physically castrated pigs. Meat Science 83, 702–705.CrossRefGoogle Scholar
Fuchs, T, Nathues, H, Koehrmann, A, Andrews, S, Brock, F, Klein, G, Beilage, E 2011. Comparative growth performance of pigs immunised with gonadotropin factor vaccine with surgically castrated pigs and entire boars raised under conventional managed conditions. Berliner und Münchener tierärztliche Wochenschrift 124, 22–27.Google Scholar
Gispert, M, Àngels Oliver, M, Velarde, A, Suarez, P, Pérez, J, Font i Furnols, M 2010. Carcass and meat quality characteristics of immunocastrated male, surgically castrated male, entire male and female pigs. Meat Science 85, 664–670.CrossRefGoogle ScholarPubMed
Grizzle, TB, Esbenshade, KL, Johnson, BH 1987. Active immunization of boars against gonadotropin releasing hormone. I. Effects on reproductive parameters. Theriogenology 27, 571–580.CrossRefGoogle ScholarPubMed
Houseknecht, KL, Baile, CA, Matteri, RL, Spurlock, ME 1998. The biology of leptin: a review. Journal of Animal Science 76, 1405–1420.CrossRefGoogle ScholarPubMed
Hemonic, A, Courboulay, V, Kuhn, G, McLaughlin, CL, Martin, VA, Brock, FC, Pearce, MC 2009. Evaluation of safety, efficiency and production benefits of vaccination against boar taint in male pigs raised under commercial field conditions in France. Revue de médecine vétérinaire 160, 383–393.Google Scholar
Higgins, JPT, Thompson, SG 2002. Quantifying heterogeneity in meta-analysis. Statistics in Medicine 21, 1539–1558.CrossRefGoogle ScholarPubMed
Hilbe, M, Jaros, P, Ehrensperger, F, Zlinszky, K, Janett, F, Hässing, M, Thun, R 2006. Histomorphological and immunohistochemical findings in testes, bulbourethral glands and brain of immunologically castrated piglets. Schweizer Archiv für Tierheilkunde 148, 599–608.CrossRefGoogle Scholar
Januskauskas, A, Zilinskas, H, Sutkeviciene, N, Bilskis, R, Szabo, I, Garlaite, K 2009. Impact of raising Improvac®-vaccinated boars on growth, carcass quality and meat quality compared to physical castrates under field conditions. Proceedings of the 21st IPVS Congress, Vancouver, Canada, p. 825.Google Scholar
Jaros, P, Bürgi, E, Stärk, KDC, Claus, R, Hennessy, D, Thun, R 2005. Effect of immunization against GnRH on androstenone concentration, growth performance and carcass quality in intact male pigs. Livestock Production Science 92, 31–38.CrossRefGoogle Scholar
Kubale, V, Fazarinc, G, Batorek, N, Škrlep, M, Šegula, B, Bonneau, M, Čandek-Potokar, M 2011. Dynamic effect of a gonadotropin-releasing hormone vaccine (Improvac®) on morphology of testes and male reproductive accessory glands: bulbourethral gland, prostate and vesicular gland in pig fatteners. Slovenian Veterinary Research 48 (suppl. 13), 203–206.Google Scholar
Kim, YH, Jung, HJ, Lee, SD, Ji, SY, Park, JC, Moon, HK 2007. Effects of immunocastration on physiological changes, the characteristic of carcass and meat quality in boars. Journal of Animal Science & Technology (Korean) 49, 753–760.Google Scholar
Kristensen, L, Therkildsen, M, Riis, BM, Sorensen, MT, Oksbjerg, N, Purslow, P, Ertbjerg, P 2002. Dietary induced changes of muscle growth rate in pigs: effects on in vivo and post-mortem muscle proteolysis and meat quality. Journal of Animal Science 80, 2862–2871.CrossRefGoogle Scholar
Lametsch, R, Kristensen, L, Larsen, MR, Therkildsen, M, Oksbjerg, N, Ertbjerg, P 2006. Changes in the muscle proteome after compensatory growth in pigs. Journal of Animal Science 84, 918–924.CrossRefGoogle ScholarPubMed
Lealiifano, AK, Pluske, JR, Nicholls, RR, Dunshea, FR, Campbell, RG, Hennessy, DP, Miller, DW, Hansen, CF, Mullan, BP 2011. Reducing the length of time between harvest and the secondary gonadotropin-releasing factor immunization improves growth performance and clears boar taint compounds in male finishing pigs. Journal of Animal Science 89, 2782–2792.CrossRefGoogle Scholar
McCauley, I, Watt, M, Suster, D, Kerton, DJ, Oliver, WT, Harrell, RJ, Dunshea, FR 2003. A GnRH vaccine (Improvac®) and porcine somatotropin (Reporcin®) have sinergistic effect upon growth performance in both boars and gilts. Australian Journal of Agricultural Research 54, 11–20.CrossRefGoogle Scholar
Medina, S, Castaneda, E, Brana, D, Cuaron, J 2008. Effects of vaccine against gonadotropin releasing factor (GNRF) on intact male pig production. Retrieved July 26, 2011, from http://www.pigprogress.net/public//Effects_of_a_vaccine_against_gonadotropin_releasing_factor_%28GnRF%29_on_intact_male_pig_production.pdf.Google Scholar
Meloen, RH, Turkstra, JA, Lankhof, H, Puijk, WC, Schaaper, WMM, Dijkstra, G, Wensing, CJG, Oonk, RB 1994. Efficient immunocastration of male piglets by immunoneutralization of GnRH using a new GnRH-like peptide. Vaccine 12, 741–746.CrossRefGoogle ScholarPubMed
Metz, C, Claus, R 2003. Active immunization of boars against GnRH does not affect growth hormone but lowers IGF-1 in plasma. Livestock Production Science 81, 129–137.CrossRefGoogle Scholar
Metz, C, Hohl, K, Waidelich, S, Drochner, W, Claus, R 2002. Active immunization of boars against GnRH at an early age: consequences for testicular function, boar taint accumulation and N-retention. Livestock Production Science 74, 147–157.CrossRefGoogle Scholar
Millet, S, Gielkens, K, De Brabander, D, Janssens, GPJ 2011. Considerations on the performance of immunocastrated male pigs. Animal 5, 1119–1123.CrossRefGoogle ScholarPubMed
Moore, KL, Dunshea, FR, Mullan, BP, Hennessy, DP, D'Souza, DN 2009. Rectopamine supplementation increases lean deposition in entire and immunocastrated male pigs. Animal Production Science 49, 1113–1119.CrossRefGoogle Scholar
Morales, J, Gispert, M, Hortos, M, Pérez, J, Suárez, P, Piñeiro, C 2010. Evaluation of production performance and carcass quality characteristics of boars immunised against gonadotropin-releasing hormone (GnRH) compared with phisically castrated male, entire male and female. Spanish Journal of Agricultural Research 8, 599–606.CrossRefGoogle Scholar
Morales, JI, Cámara, L, Berrocoso, JD, López, JP, Mateos, GG, Serrano, MP 2011. Influence of sex and castration on growth performance and carcass quality of crossbred pigs from two Large White sire lines. Journal of Animal Science 89, 3481–3489.CrossRefGoogle Scholar
Oliver, WT, McCauley, I, Harrell, RJ, Suster, D, Kerton, DJ, Dunshea, FR 2003. A gonadotropin-releasing factor vaccine (Improvac) and porcine somatotropin have synergistic and additive effects on growth performance in group-housed boars and gilts. Journal of Animal Science 81, 1959–1966.CrossRefGoogle ScholarPubMed
Patterson, RLS 1968. 5α-androst-16-ene-3-one: compound responsible for taint in boar fat. Journal of the Science of Food and Agriculture 19, 31–38.CrossRefGoogle Scholar
Pauly, C, Spring, P, O'Doherty, JV, Kragten, SA, Bee, G 2009. Growth performance, carcass characteristics and meat quality of group-penned surgically castrated, immunocastrated (Improvac®) and entire male pigs and individually penned entire male pigs. Animal 3, 1057–1066.CrossRefGoogle ScholarPubMed
Pearce, M, Andrews, S, Brock, F, Allison, J 2009. Effects of vaccination with Improvac® on boar taint and carcase quality of male pigs reared under commercial conditions in Europe. 55th International Congress of Meat Science and Technology, Copenhagen, Denmark, August 16–21, PE1.08.Google Scholar
PIGCAS 2009. Report on recommendations for research and policy support. Deliverable D4.1 of the EU project PIGCAS: attitude, practices and state of the art regarding piglet castration in Europe. Retrieved September 10, 2011 from http://w3.rennes.inra.fr/pigcas.Google Scholar
Ramsay, TG 1999. Leptin: a regulator of feed intake and physiology in swine. In Manipulating pig production VIII (ed. PD Cranwell), pp. 157–170. Australian Pig Science Association, Werribe, Vic., Australia.Google Scholar
Ramsay, TG, Yan, X, Morrison, C 1998. The obesity gene in swine: sequence and expression of porcine leptin. Journal of Animal Science 76, 484–490.CrossRefGoogle ScholarPubMed
Rikard-Bell, C, Curtis, MA, van Barneveld, RJ, Mullan, BP, Edwards, AC, Gannon, NJ, Henman, DJ, Hughes, PE, Dunshea, FR 2009. Rectopamine hydrochloride improves growth performance and carcass composition in immunocastrated boars, intact boars, and gilts. Journal of Animal Science 87, 3536–3543.CrossRefGoogle ScholarPubMed
Sather, AP, Jones, SDM, Squires, EJ, Schaefer, AL, Robertson, WM, Tong, AKW, Zawadski, S 1995. Antemortem handling effects on the behaviour, carcass yield and meat quality of market weight entire male pigs. Canadian Journal of Animal Science 75, 45–56.Google Scholar
Saville, DJ, Rowarth, JS 2008. Statistical measures, hypotheses, and tests in applied research. Journal of Natural Resources and Life Sciences Education 37, 74–82.CrossRefGoogle Scholar
Schmoll, F, Kauffold, J, Pfützner, A, Baumgartner, J, Brock, F, Grodzycki, M, Andrews, S 2009. Growth performance and carcass traits of boars raised in Germany and either surgically castrated of vaccinated against gonadotropin-releasing hormone. Journal of Swine Health and Production 17, 250–255.Google Scholar
Škrlep, M, Šegula, B, Zajec, M, Kastelic, M, Košorok, S, Fazarinc, G, Čandek-Potokar, M 2010a. Effect of immunocastration (Improvac®) in fattening pigs I: growth performance, reproductive organs and malodourous compounds. Slovenian Veterinary Research 47, 57–64.Google Scholar
Škrlep, M, Šegula, B, Prevolnik, M, Kirbiš, A, Fazarinc, G, Čandek-Potokar, M 2010b. Effect of immunocastration (Improvac®) in fattening pigs II: carcass traits and meat quality. Slovenian Veterinary Research 47, 65–72.Google Scholar
Therkildsen, M, Vestergaard, M, Busk, H, Jensen, MT, Riis, B, Karlsson, AH, Kristensen, L, Ertbjerg, P, Oksbjerg, N 2004. Compensatory growth in slaughter pigs – in vitro muscle protein turnover at slaughter, circulating IGF-1, performance and carcass quality. Livestock Production Science 88, 63–75.CrossRefGoogle Scholar
Turkstra, JA, van Diepen, JTM, Jongbloed, AW, Oonk, HB, van de Wiel, DFM, Meloen, RH 2002. Performance of male pigs immunized against GnRH is related to the time of onset of biological response. Journal of Animal Science 80, 2953–2959.CrossRefGoogle Scholar
van Laack, RJM, Stevens, SG, Stalder, KJ 2001. The influence of ultimate pH and intramuscular fat content on pork tenderness and tenderization. Journal of Animal Science 79, 392–397.CrossRefGoogle ScholarPubMed
Vold, E 1970. Fleishproduktionseigenschaften bei Ebern Kastraten IV: Organoleptische und gaschromatographische Untersuchungen wasserdampfflüchtiger Stoffe des Rückenspeckes von Ebern. Maldinger fra Norges Landbrukshøgskole 49, 1–25.Google Scholar
Walstra, P, Maarse, G 1970. Onderzoek gestachlengen von mannelijke mestvarkens, Researchrroep voor Vlees en Vleeswaren TNO. IVO-Rapport C 147, 30 pp., Zeist, The Netherlands.Google Scholar
Zamaratskaia, G, Andersson, HK, Chen, G, Andersson, K, Madej, A, Lundström, K 2008a. Effect of a gonadotropin-releasing hormone vaccine (Improvac™) on steroid hormones, boar taint compounds and performance in entire male pigs. Reproduction in Domestic Animals 43, 351–359.CrossRefGoogle ScholarPubMed
Zamaratskaia, G, Rydhmer, L, Andersson, HK, Chen, G, Lowagie, S, Andersson, K, Lundström, K 2008b. Long-term effect of vaccination against gonadotropin-releasing hormon, using ImprovacTM, on hormonal profile and behaviour of male pigs. Animal Reproduction Science 108, 37–48.CrossRefGoogle ScholarPubMed
Zankl, A, Götz, R, Pausenberger, A, Dodenhoff, J, Wittmann, W 2011. Impfung gegen Ebergeruch-Erfahrungen und Ergebnisse einer Feldstudie in Bayern. Der Praktische Tierarzt 92, 148–154.Google Scholar
Zeng, XY, Turkstra, JA, van de Wiel, DFM, Guo, DZ, Liu, XY, Meloen, RH, Schaaper, WMM, Chen, FQ, Oonk, HB, Zhang, X 2001. Active immunization against gonadotrophin-releasing hormone in Chinese male pigs. Reproduction in Domestic Animals 36, 101–105.CrossRefGoogle ScholarPubMed
Zeng, XY, Turkstra, JA, Meloen, RH, Liu, XY, Chen, FQ, Schaaper, WMM, Oonk, HB, Guo, DZ, van de Wiel, DFM 2002a. Active immunization against gonadotrophin-releasing hormone in Chinese male pigs: effects of dose on antibody titre, hormone levels and sexual development. Animal Reproduction Science 70, 223–233.CrossRefGoogle ScholarPubMed
Zeng, XY, Turkstra, JA, Jongbloed, AW, van Diepen, JTM, Meloen, RH, Oonk, HB, Guo, DZ, van de Wiel, DFM 2002b. Performance and hormone levels of immunocastrated, surgically castrated and intact male pigs fed ad libitum high- and low-energy diets. Livestock Production Science 77, 1–11.CrossRefGoogle Scholar
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