Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-23T18:50:46.545Z Has data issue: false hasContentIssue false
  • English
  • Français

Immune and oxidative response to linseed in the diet of periparturient Holstein cows

Published online by Cambridge University Press:  19 March 2015

M. Đidara ,
N. Poljičak-Milas ,
S. Milinković-Tur ,
T. Mašek ,
J. Šuran ,
M. Pavić ,
M. Kardum  and
M. Šperanda
M. Đidara*
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
N. Poljičak-Milas
Affiliation:
Department of Pathophysiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
S. Milinković-Tur
Affiliation:
Department of Physiology and Radiobiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
T. Mašek
Affiliation:
Department of Animal Nutrition and Dietetics, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
J. Šuran
Affiliation:
Department of Pharmacology and Toxicology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
M. Pavić
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
M. Kardum
Affiliation:
Department of Pathophysiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
M. Šperanda
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
*
†E-mail: [email protected]
Get access

Abstract

The aim of this research was to determine the influence of dietary replacement of n-6 with n-3 polyunsaturated fatty acids on cellular immunity and oxidative stress in the transition period dairy cows. The experiment was conducted on 20 dairy Holstein cows from 3±1 weeks before parturition until the 6th week of lactation. Both groups were fed an iso-energetic and iso-nitrogenous diet. Soybean meal from control (C) group was replaced with linseed in the experimental (LS) group. Cellular immunity and oxidative stress were measured on days −10, 1, 21 and 42 relative to parturition. During the entire experimental period, the proportion of CD45+ cells was lower (P<0.05) in LS group compared with the C group. The phagocytosis ability and phagocytosis index of cows fed with n-3 fatty acids were significantly reduced (P<0.05) compared with the group of cows fed with n-6 fatty acids. The most severe decrease in phagocytosis ability was on day −10 and 1 relative to parturition. The activity of superoxide dismutase (P<0.05) and plasma glutathione peroxidase (P<0.05) increased around calving, although activities were not influenced by dietary treatment. Increased malondialdehyde concentration (P<0.05) was influenced by dietary n-3 fatty acids and the time relative to parturition. The immune suppression was most pronounced during periparturient period. In that matter we can conclude that not only dietary n-3 fatty acids but also oxidative stress, which reached peak at time of parturition, contributed to the reduced cellular immunity during the periparturient period.

Keywords

dairy cowsimmune responseoxidative stresslinseedfatty acids
Type
Research Article
Information
animal , Volume 9 , Issue 8 , August 2015 , pp. 1349 - 1354
Copyright
© The Animal Consortium 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Association of Official Analytical Chemists 1995. Official methods of analysis, vol. 2, 16th edition. AOAC, Arlington, VA, USA.Google Scholar
Buetler, EO, Duron, B and Mikus, K 1963. Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine 61, 882–886.Google Scholar
Calder, PC, Bond, JA, Harvey, DJ, Gordon, S and Newsholme, EA 1990. Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis. Biochemical Journal 269, 807–814.Google Scholar
Castillo, C, Hernandez, J, Bravo, A, Lopez, AM, Pereira, V and Benedito, JL 2005. Oxidative status during late pregnancy and early lactation in dairy cows. The Veterinary Journal 169, 286–292.Google Scholar
Castillo, C, Hernández, J, Valverde, I, Pereira, V, Sotillo, J, López, AM and Benedito, JL 2006. Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science 80, 133–139.Google Scholar
Gallardo, B, Gómez-Cortés, P, Mantecón, AR, Juárez, M, Manso, T and de la Fuente, MA 2014. Effects of olive and fish oil Ca soaps in ewe diets on milk fat and muscle and subcutaneous tissue fatty-acid profiles of suckling lambs. Animal 7, 1178–1190.Google Scholar
Goodarzi, K, Goodarzi, M, Tager, AM, Luster, AD and Andrian, UH 2003. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nature Immunology 4, 965–973.Google Scholar
Grotto, D, Santa Maria, LD, Boeira, S, Valentini, J, Charäo, MF, Moro, AM, Nascimento, PC, Pomblum, VJ and Garcia, SC 2007. Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography–visible detection. Journal of Pharmaceutical and Biomedical Analysis 43, 619–624.Google Scholar
Jefferies, H, Coster, J, Khalil, A, Bot, J, McCauley, RD and Hall, JC 2003. Glutathione. ANZ Journal of Surgery 73, 517–522.CrossRefGoogle ScholarPubMed
Kataria, N, Kataria, AK, Maan, R and Gahlot, AK 2010. Evaluation of oxidative stress in brucella infected cows. Journal of Stress Physiology and Biochemistry 6, 19–25.Google Scholar
Lejonkleva, J, Storma, AC, Larsena, MK, Mortensena, G and Weisbjerg, MR 2013. Differences in rate of ruminal hydrogenation of C18 fatty acids in clover and ryegrass. Animal 7, 1607–1613.Google Scholar
Nudda, A, Battaconea, G, Atzoria, AS, Dimauroa, C, Rassua, SPG, Nicolussia, P, Bonellia, P and Pulina, G 2013. Effect of extruded linseed supplementation on blood metabolic profile and milk performance of Saanen goats. Animal 7, 1464–1471.Google Scholar
Ordóňez, V, Pescador, SN, Gorodezky, C and Saltijeral, OJ 2008. In vitro differential neutrophil phagocytosis activity on Staphylococcus aureus when obtained from blood and milk of dairy cows in early lactation period. Revista Latinoamericana de Microbiología 50, 66–71.Google Scholar
Pantazis, CG and Kniker, WT 1979. Assessment of blood leukocyte microbial killing by using a new fluorochrome microassay. Journal of the Reticuloendothelial Society 26, 155–170.Google ScholarPubMed
Pedernera, M, Celi, P, Garcia, SC, Salvin, HE, Barchia, I and Fulkerson, WJ 2010. Effect of diet, energy balance and milk production on oxidative stress in early-lactating cows grazing pasture. The Veterinary Journal 186, 352–357.Google Scholar
Peters-Golden, M and Henderson, WR Jr. 2007. Leukotrienes. The New England Journal of Medicine 357, 1841–1854.CrossRefGoogle ScholarPubMed
Runarsson, G, Liu, A, Mahshid, Y, Feltenmark, S, Pettersson, A, Klein, E, Björkholm, M and Claesson, HE 2005. Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells. Blood 105, 1274–1279.Google Scholar
Scholljegerdes, EJ, Lekatz, LA and Vonnahme, KA 2014. Effects of short-term oilseed supplementation on plasma fatty acid composition, progesterone and prostaglandin F metabolite in lactating beef cows. Animal 8, 777–785.Google Scholar
Shingfield, KJ, Reynolds, CK, Lupoli, B, Toivonen, V, Yurawecz, MP, Delmonte, P, Griinari, JM, Grandison, AS and Beever, DE 2005. Effect of forage type and proportion of concentrate in the diet on milk fatty acid composition in cows fed sunflower oil and fish oil. Journal of Animal Science 80, 225–238.CrossRefGoogle Scholar
Silvestre, FT, Carvalho, TSM, Crawford, PC, Santos, JEP, Staples, CR, Jenkins, T and Thatcher, WW 2011. Effects of differential supplementation of fatty acids during the peripartum and breeding periods of Holstein cows: II. Neutrophil fatty acids and function, and acute phase proteins. Journal of Dairy Science 94, 2285–2301.Google Scholar
Sordillo, LM and Aitken, SL 2009. Impact of oxidative stress on health and immune function of dairy cattle. Veterinary Immunology and Immunopathology 128, 104–109.Google Scholar
Stankova, J, Gagnon, N and Rola-Pleszczynski, M 1992. Leukotriene B4 augments interleukin-2 receptor-beta (IL-2R beta) expression and IL-2R beta-mediated cytotoxic response in human peripheral blood lymphocytes. Immunology 16, 258–263.Google Scholar
Stefanon, B, Sgorlon, S and Gabai, G 2005. Usefulness of nutraceutics in controlling oxidative stress in dairy cows around parturition. Veterinary Research Communications 29, 387–390.Google Scholar
Tager, AM, Bromley, SK and Medoff, BD 2003. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nature Immunology 4, 982–990.Google Scholar