Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-05T02:42:45.704Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of oestrous synchronization with altrenogest in gilts on endometrial and embryonic characteristics

Published online by Cambridge University Press:  15 April 2020

G. M. Ravagnani ,
C. H. G. Martinez ,
R. F. Carnevale ,
B. B. D. Muro ,
M. V. Mendonça ,
A. P. P. Pavaneli ,
M. S. Passareli ,
D. H. Nakasone ,
R. F. Strefezzi  and
S. M. M. K. Martins
...Show all authors
G. M. Ravagnani
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
C. H. G. Martinez
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
R. F. Carnevale
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
B. B. D. Muro
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
M. V. Mendonça
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
A. P. P. Pavaneli
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
M. S. Passareli
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
D. H. Nakasone
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
R. F. Strefezzi
Affiliation:
Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
S. M. M. K. Martins
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil Faculty of Animal Science and Food Engineering, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
A. F. C. Andrade*
Affiliation:
Swine Research Center, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga13635-900, Brazil
*
†Email: [email protected]
Get access

Abstract

The use of altrenogest (ALT) supplementation for oestrous synchronization improves subsequent reproductive performance of gilts and sows. However, the causes of this improvement in reproductive performance after ALT treatment are not fully/clearly understood. The objective of this study was to evaluate the effects of ALT supplementation for oestrous synchronization in gilts on the endometrial glands and embryonic development characteristics at 28 days of pregnancy. Pregnant gilts were divided into two experimental treatments: Control (did not receive ALT; n = 9 gilts) and ALT (ALT feeding at 20 mg/day for 18 days; n = 9 gilts). At 28 days of pregnancy, six gilts from each treatment were slaughtered, and reproductive tracts were immediately evaluated. There was no statistical difference (P > 0.05) between treatments regarding ovulation rate, number of embryos, number of vital embryos and number of non-vital embryos. Embryo weight, length and embryonic vesicle weight were lower in ALT treatment compared with Control (P < 0.01), and it was lower in the cervical uterine region compared with apex uterine region, respectively (P < 0.05). Higher values of gland duct area, gland duct perimeter, percentage of the glandular area and total endometrial area were observed in ALT treatment compared with Control (P < 0.05). The use of ALT during 18 days for oestrous synchronization in gilts increased the gland duct area, perimeter and total endometrial area but did not increase the embryo number and embryo size at day 28 of pregnancy.

Keywords

altrenogestembryonic developmentendometriumgiltspregnancy
Type
Research Article
Information
animal , Volume 14 , Issue 9 , September 2020 , pp. 1899 - 1905
Copyright
© The Animal Consortium 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bailey, DW, Dunlap, KA, Erikson, DW, Patel, AK, Bazer, FW, Burghardt, RC and Johnson, GA 2010. Effects of long-term progesterone exposure on porcine uterine gene expression: progesterone alone does not induce secreted phosphoprotein 1 (osteopontin) in glandular epithelium. Reproduction 140, 595–604.CrossRefGoogle Scholar
Basha, SM, Bazer, FW and Roberts, RM 1980. Effect of the conceptus on quantitative and qualitative aspects of uterine secretion in pigs. Journal of Reproduction and Fertility 60, 41–48.CrossRefGoogle ScholarPubMed
Bazer, FW 1975. Uterine protein secretions: relationship to development of the conceptus. Journal of Animal Science 41, 1376–1382.CrossRefGoogle ScholarPubMed
Che, L, Xu, M, Yang, Z, Xu, S, Che, L, Lin, Y, Fang, Z, Feng, B, Li, J, Chen, D and Wu, D 2016. Detection of placental proteomes at different uterine positions in Large White and Meishan gilts on gestational day 90. PLoS ONE 11, 1–16.CrossRefGoogle ScholarPubMed
Da Silva, CL, Van den Brand, H, Laurenssen, BF, Broekhuijse, ML, Knol, EF, Kemp, B and Soede, NM 2016. Relationships between ovulation rate and embryonic and placental characteristics in multiparous sows at 35 days of pregnancy. Animal 10, 1192–1199.CrossRefGoogle ScholarPubMed
De Rensis, F, Mazzoni, C, Saleri, R, Scollo, A, Plush, KJ and Kirkwood, RN 2017. Effect of duration of altrenogest treatment on farrowing rate and litter size of gilts. Animal Production Science 58, 2029–2031.CrossRefGoogle Scholar
Dos, SJ, Wentz, I, Bortolozzo, FP and Barioni, WJ 2004. Early-weaned sows: altrenogest therapy, estrus, ovulation, and reproductive performance. Animal Reproduction Science 84, 407–413.Google Scholar
Fernandez, L, Diez, C, Ordonez, JM and Carbajo, M 2005. Reproductive performance in primiparous sows after postweaning treatment with a progestagen. Journal of Swine Health and Production 13, 28–30.Google Scholar
Gelsert, RD, Renegar, RH, Thatcher, WW, Roberts, RM and Bazer, FW 1982. Establishment of pregnancy in the pig: I. Interrelationships between preimplantation development of the pig blastocyst and uterine endometrial secretions. Biology of Reproduction 27, 925–939.CrossRefGoogle Scholar
Guimarães, GC, Betarelli, RP, Zangeronimo, MG, Abreu, ML, Almeida, FR, Rosa, MC, Ferreira, LG, Alves, LA, Assis, CK and Lopes, GC 2014. Vascularization of broad ligament of uterus and its relationship with fetal and placental development in gilts. Theriogenology 82, 232–237.CrossRefGoogle ScholarPubMed
He, LC, Li, PH, Ma, X, Sui, SP, Gao, S, Kim, SW, Gu, YQ, Huang, Y, Ding, NS and Huang, RH 2017. Identification of new single nucleotide polymorphisms affecting total number born and candidate genes related to ovulation rate in Chinese Erhualian pigs. Animal Genetics 48, 48–54.CrossRefGoogle ScholarPubMed
Kim, SW, Hurley, WL, Wu, G and Ji, F 2009. Ideal amino acid balance for sows during gestation and lactation. Journal of Animal Science 87, E123–E132.CrossRefGoogle ScholarPubMed
Kim, SW, Weaver, AC, Shen, YB and Zhao, Y 2013. Improving efficiency of sow productivity: nutrition and health. Journal of Animal Science and Biotechnology 4, 26.CrossRefGoogle ScholarPubMed
Kirkwood, RN, Smith, WC and Lapwood, KR 1986. Influence of oral administration of allyl trenbolone on subsequent litter size of primiparous sows. New Zealand Journal of Experimental Agriculture 14, 477–480.CrossRefGoogle Scholar
Knight, JW, Bazer, FW, Wallace, HD and Wilcox, CJ 1974. Dose-response relationships between exogenous progesterone and estradiol and porcine uterine protein secretions. Journal of Animal Science 39, 747–751.CrossRefGoogle ScholarPubMed
Kraeling, RR and Webel, SK 2015. Current strategies for reproductive management of gilts and sows in North America. Journal of Animal Science and Biotechnology 6, 3.CrossRefGoogle ScholarPubMed
Lopes, T, Bolarín, A, Martínez, E and Roca, J 2017. Altrenogest treatment before weaning improves litter size in sows. Reproduction in Domestic Animals 52, 75–77.CrossRefGoogle ScholarPubMed
Martinat-Botté, F, Bariteau, F, Forgerit, Y, Macar, C, Poirier, P and Terqui, M 1995. Synchronization of oestrus in gilts with altrenogest: effects on ovulation rate and foetal survival. Animal Reproduction Science 39, 267–274.CrossRefGoogle Scholar
Palencia, JYP, Garbossa, CAP, Betarelli, RP, Fonseca, LS, Lanferdini, E, Guimarães, GC, Zangeronimo, MG, Schinckel, AP and Abreu, MLT 2018. Swine foetal myogenesis in different gestation periods. Journal of Animal Physiology and Animal Nutrition 102, e99–e105.CrossRefGoogle ScholarPubMed
Perry, JS and Crombie, PR 1982. Ultrastructure of the uterine glands of the pig. Journal of Anatomy 134, 339–350.Google ScholarPubMed
Prophet, EB, Mills, B, Arrington, JB and Sobin, LH 1992. Laboratory Methods in Histotechnology. American Registry of Pathology. Armed Forces Institute of Pathology, Washington, DC, USA.Google Scholar
Quesnel, H, Brossard, L, Valancogne, A and Quiniou, N 2008. Influence of some sow characteristics on within-litter variation of piglet birth weight. Animal 12, 1842–1849.CrossRefGoogle Scholar
Rasband, WS and Ferreira, T 2012. ImageJ. U. S. Image Processing and Analysis in Java, National Institutes of Health. Retrieved on 10 April 2018 from http://imagej.nih.gov/ij/Google Scholar
Roberts, RM and Bazer, FW 1988. The functions of uterine secretions. Journal of Reproduction and Fertility 82, 875–892.CrossRefGoogle ScholarPubMed
Rostagno, HS, Albino, LFT, Hannas, MI, Donzele, JL, Sakomura, NK, Perazzo, FG, Saraiva, A, Teixeira, ML, Rodrigues, PB, Oliveira, RF, Barreto, SLT and Brito, CO 2017. Tabelas brasileiras para aves e suínos: composição de alimentos e exigências nutricionais, 4a Edição. Viçosa/Departamento de Zootecnia, UFV, Viçosa, Brazil.Google Scholar
SAS 2011. SAS/STAT® 9.3 userʼs guide. Statistical Analysis Systems Institute Inc., Cary, NC, USA.Google Scholar
Sinowatz, F and Friess, AE 1983. Uterine glands of the pig during pregnancy: an ultrastructural and cytochemical study. Anatomy and Embryology 166, 121–134.CrossRefGoogle ScholarPubMed
Spencer, TE, Kelleher, AM and Bartol, FF 2019. Development and function of uterine glands in domestic animals. Annual Review of Animal Biosciences 15, 125–147.CrossRefGoogle Scholar
Town, SC, Putman, CT, Turchinsky, NT, Dixon, WT and Foxcroft, GR 2004. Number of conceptuses in utero affects porcine fetal muscle development. Reproduction 128, 443–454.CrossRefGoogle ScholarPubMed
Vallet, JL, Freking, BA and Miles, JR 2011. Effect of empty uterine space on birth intervals and fetal and placental development in pigs. Animal Reproduction Science 125, 158–164.CrossRefGoogle ScholarPubMed
Van der Waaij, EH, Hazegeler, W, Soede, NM, Laurenssen, BFA and Kemp, B 2010. Effect of excessive hormonally induced intrauterine crowding in the gilt on fetal development on day 40 of pregnancy. Journal of Animal Science 88, 2611–2619.CrossRefGoogle ScholarPubMed
Viana, CHC, Silveira, PRS, Moretti, AS and Rodrigues, PHM 1999. Relações entre as características intervalo desmame-cio, duração do cio e momento da ovulação diagnosticado pela ultra-sonografia em fêmeas da espécie suína. Brazilian Journal of Veterinary Research and Animal Science 36, 212–218.CrossRefGoogle Scholar
Wang, Z, Liu, BS, Wang, XY, Wei, QH, Tian, H and Wang, LQ 2018. Effects of altrenogest on reproductive performance of gilts and sows: a meta-analysis. Animal Reproduction Science 197, 10–21.CrossRefGoogle ScholarPubMed
Wilson, ME, Biensen, NJ, Youngs, CR and Ford, SP 1998. Development of Meishan and Yorkshire littermate conceptuses in either a Meishan or Yorkshire uterine environment to day 90 of gestation and to term. Biology of Reproduction 58, 905–910.CrossRefGoogle ScholarPubMed
Wise, T, Roberts, AJ and Christenson, RK 1997. Relationships of light and heavy fetuses to uterine position, placental weight, gestational age, and fetal cholesterol concentrations. Journal of Animal Science 75, 197–207.CrossRefGoogle ScholarPubMed