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Effects of maternal nutrient restriction during early or mid-gestation without realimentation on maternal physiology and foetal growth and development in beef cattle

Published online by Cambridge University Press:  12 July 2017

R. K. Taylor ,
C. T. LeMaster ,
K. S. Mangrum ,
R. E. Ricks  and
N. M. Long
R. K. Taylor
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
C. T. LeMaster
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
K. S. Mangrum
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
R. E. Ricks
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
N. M. Long*
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
*
†E-mail: [email protected]
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Abstract

The aim of this study is to determine the effects of early and mid-gestation nutrient restriction on maternal metabolites and foetal growth. Primiparous Angus cows were synchronized and inseminated with semen from one sire. Dietary treatments were: control to gain 1 kg/week (CON) or 0.55% maintenance energy and CP requirements (nutrient restricted; NR). A subset of dams was fed NR (n=8) or CON (n=8) from days 30 to 110 of gestation. Another group was fed CON (n=8), days 30 to 190; NR (n=7), days 30 to 110 followed by CON days 110 to 190; or CON, (n=7) days 30 to 110 followed by NR days 110 to 190. Cows were harvested at days 110 or 190 of gestation, when foetal measurements and samples were collected. Cows that were NR during days 30 to 110 or 110 to 190 of gestation lost significant BW and body condition score (P<0.001), this was associated with reduced plasma glucose during NR (P<0.002). Foetal weights, empty foetal weights, abdominal and thoracic circumferences were all reduced (P<0.03) in day 110 NR animals. Foetal perirenal adipose as a percentage of empty foetal weight was increased (P=0.01) in NR day 110 female foetuses compared with CON foetus. Maternal serum triglycerides at day 110 of gestation were decreased (P<0.05) in NR dams, whereas foetal serum triglycerides were increased (P<0.05) in response to maternal NR. Foetal weights tended to be reduced (P=0.08) in NR/CON and CON/NR v. CON/CON cattle at day 190 of gestation. Empty foetal weights, abdominal and thoracic circumferences were reduced (P⩽0.03) in NR/CON and CON/NR v. CON/CON cattle. Brain weight as a percentage of empty foetal weight was increased (P<0.001) in NR/CON and CON/NR v. CON/CON cattle. Foetal perirenal adipose as a percentage of empty foetal weight was increased (P=0.003) in NR/CON and CON/NR v. CON/CON cattle. Maternal serum triglycerides at day 190 of gestation were decreased (P<0.05) in association with maternal NR. Foetal serum triglycerides at day 190 of gestation were increased (P<0.05) in response to maternal NR during early gestation but decreased by NR in mid gestation compared with CON foetuses. The data show that maternal nutrient restriction during early or mid-gestation cause’s asymmetrical foetal growth restriction, regardless if the restriction is preceded or followed by a period of non-restriction.

Keywords

bos taurusfoetal growthfoetal programmingmaternal metabolitesmaternal undernutrition
Type
Research Article
Information
animal , Volume 12 , Issue 2 , February 2018 , pp. 312 - 321
Copyright
© The Animal Consortium 2017 

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References

Anthony, RV, Scheaffer, AN, Wright, CD and Regnault, TRH 2003. Ruminant models of prenatal growth restriction. Reproduction Supplement 61, 183–194.Google Scholar
Baker, DH, Becker, DE, Norton, HW, Sasse, CE, Jensen, AH and Harmon, BG 1969. Reproductive performance and progeny development in swine as influenced by feed intake during pregnancy. Journal of Nutrition 97, 489–495.CrossRefGoogle ScholarPubMed
Camacho, LE, Lemley, CO, Van Emon, ML, Caton, JS, Swanson, KC and Vonnahme, KA 2014. Effects of maternal nutrient restriction followed by realimentation during early and midgestation on beef cows. I. Maternal performance and organ weights at different stages of gestation. Journal of Animal Science 92, 520–529.CrossRefGoogle ScholarPubMed
Edison, RJ, Berg, K, Remaley, A, Kelley, R, Rotimi, C, Stevenson, RE and Muenke, M 2007. Adverse birth outcome among mothers with low serum cholesterol. Pediatrics 120, 723–733.CrossRefGoogle ScholarPubMed
Edwards, LJ, McFarlane, JR, Kauter, KG and McMillen, IC 2005. Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 28, R39–R45.Google Scholar
Ford, SP 1995. Control of blood flow to the gravid uterus of domestic livestock species. Journal of Animal Science 73, 1852–1860.Google Scholar
Ford, SP, Hess, BW, Schwope, MM, Nijland, MJ, Gilbert, JS, Vonnahme, KA, Means, WJ, Han, H and Nathanielsz, PW 2007. Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring. Journal of Animal Science 85, 1285–1294.CrossRefGoogle ScholarPubMed
George, LA, Zhange, L, Tuersunjiang, N, Ma, Y, Long, NM, Uthlaut, AB., Smith, DT, Nathanielsz, PW and Ford, SP 2012. Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 302, R795–R804.Google Scholar
Hernandez-Medrano, JH, Copping, KJ, Hoare, A, Wapanaar, W, Grivell, R, Kuchel, T, Miguel-Pacheco, G, McMillen, IC, Rodgers, RJ and Perry, VEA 2015. Gestational dietary protein Is associated with sex specific decrease in blood flow, fetal heart growth and post-natal blood pressure of progeny. PLoS ONE 10, e0125694.Google Scholar
Lay, DC, Randel, RD, Friend, TH, Carroll, JA, Welsh, TH, Jenkins, OC, Neuendorff, DA, Bushong, DM and Kapp, GM 1997. Effects of prenatal stress on the fetal calf. Domestic Animal Endocrinology 14, 73–80.CrossRefGoogle ScholarPubMed
Long, NM, Burns, TA, Duckett, SK and Schafer, DW 2014. Reproductive performance and serum fatty acid profiles of underdeveloped beef heifers supplemented with saturated or unsaturated rumen bypass fat compared to an isocaloric control. Professional Animal Scientist 30, 502–509.Google Scholar
Long, NM, Prado-Cooper, MJ, Krehbiel, CR, DeSilva, U and Wettemann, RP 2010. Effects of nutrient restriction of bovine dams during early gestation on postnatal growth, carcass and organ characteristics, and gene expression in adipose tissue and muscle. Journal of Animal Science 88, 3251–3261.Google Scholar
Long, NM, Rule, DC, Zhu, MJ, Nathanielsz, PW and Ford, SP 2012a. Maternal obesity upregulates fatty acid and glucose transporters and increases expression of enzymes mediating fatty acid biosynthesis in fetal adipose tissue depots. Journal of Animal Science 90, 2201–2210.Google Scholar
Long, NM and Schafer, DW 2013. Sex effects on plasma leptin concentrations in newborn and postnatal beef calves. Professional Animal Scientist 29, 601–605.Google Scholar
Long, NM, Tousley, CB, Underwood, KR, Paisley, SI, Means, WJ, Hess, BW, Du, M and Ford, SP 2012b. Effects of early to mid-gestational undernutrition with or without protein supplementation on offspring growth, carcass characteristics, and adipocyte size in beef cattle. Journal of Animal Science 90, 197–206.CrossRefGoogle ScholarPubMed
Long, NM, Vonnahme, KA, Hess, BW, Nathanielsz, PW and Ford, SP 2009. Effects of early gestational undernutrition on fetal growth, organ development, and placentomal composition in bovine. Journal of Animal Science 87, 1950–1959.Google Scholar
Ma, Y, Zhu, MJ, Uthlaut, AB, Nijland, MJ, Nathanielsz, PW, Hess, BW and Ford, SP 2011. Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes. Placenta 3, 255–263.CrossRefGoogle Scholar
McConihay, JA, Honkomp, AM, Granholm, NA and Woollett, LA 2000. Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse. Journal of Lipid Research 41, 424–432.Google Scholar
McMillen, IC, Adams, MB, Ross, JT, Coulter, CL, Simonetta, G, Owens, JA, Robinson, JS and Edwards, LJ 2001. Fetal growth restriction: adaptations and consequences. Reproduction 122, 195–204.CrossRefGoogle ScholarPubMed
Miller, SL, Sutherland, AE, Supramaniam, VG, Walker, DW, Jenkin, G and Wallace, EM 2012. Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine foetuses in a sex-specific manner. Reproduction, Fertility and Development 24, 753–758.Google Scholar
Mossa, F, Carter, F, Walsh, SW, Kenny, DA, Smith, GW, Ireland, JL, Hildebrandt, TB, Lonergan, P, Ireland, JJ and Evans, ACO 2013. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biology of Reproduction 88, 1–9.CrossRefGoogle ScholarPubMed
National Research Council (NRC) 1996. Nutrient requirements of beef cattle, 7th revised edition. National Academy Press, Washington, DC, USA.Google Scholar
Pedersen, JF 1980. Ultrasound evidence of sexual difference in fetal size in first trimester. British Medical Journal 281, 1253.Google Scholar
Platz, E and Newman, R 2008. Diagnosis of IUGR: traditional biometry. Seminars in Perinatology 32, 140–147.Google Scholar
Prezotto, LD, Camacho, LE, Lemley, CO, Keomanivong, FE, Caton, JS, Vonnahme, KA and Swanson, KC 2016. Nutrient restriction and realimentation in beef cows during early and mid-gestation and maternal and fetal hepatic and small intestine in vitro oxygen consumption. Animal 10, 829–837.Google Scholar
Tuersunjiang, NJ, Odhiambo, FJ, Long, NM, Shasa, DR, Nathanielsz, PW and Ford, SP 2013. Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels. American Journal of Physiology – Endocrinology and Metabolism 7, E868–E878.Google Scholar
Vonnahme, KA, Hess, BW, Hansen, TR, McCormick, RJ, Rule, DC, Moss, GE, Murdoch, WJ, Nijland, MJ, Skinner, DC, Nathanielsz, PW and Ford, SP 2003. Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biology of Reproduction 69, 133–140.Google Scholar
Wagner, JJ, Lusby, KS, Oltjen, JW, Rakestraw, J, Wettemann, RP and Walters, LE 1988. Carcass composition in mature Hereford cows: estimation and effect on daily metabolizable energy requirement during winter. Journal of Animal Science 66, 603–612.Google Scholar
Wang, P, Mariman, P, Renes, J and Keijer, J 2008. The secretory function of adipocytes in the physiology of white adipose tissue. Journal of Cell Physiology 216, 3–13.CrossRefGoogle ScholarPubMed
Woollett, L 2011. Review: transport of maternal cholesterol to the fetal circulation. Placenta 32 (suppl. 2), S218–S221.Google Scholar
Zhu, MJ, Ma, Y, Long, NM, Du, M and Ford, SP 2010. Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 299, R1224–R1231.Google Scholar