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Relationships between thyroid hormones and serum energy metabolites with different patterns of postpartum luteal activity in high-producing dairy cows

Published online by Cambridge University Press:  23 January 2012

M. Kafi ,
A. Tamadon ,
M. Saeb ,
A. Mirzaei  and
M. Ansari-Lari
M. Kafi*
Affiliation:
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
A. Tamadon
Affiliation:
Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz 71345, Iran
M. Saeb
Affiliation:
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
A. Mirzaei
Affiliation:
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
M. Ansari-Lari
Affiliation:
Department of Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz 71345, Iran
*
†E-mail: [email protected]
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Abstract

This study investigated the relationships of thyroid hormones, serum energy metabolites, reproductive parameters, milk yield and body condition score with the different patterns of postpartum luteal activity in the postpartum period. A total of 75 multiparous healthy (free of detectable reproductive disorders) Holstein dairy cows (mean peak milk yield = 56.5 ± 7.0 kg/day) were used in this study. Transrectal ultrasound scanning and blood sample collection were performed twice weekly. Serum concentrations of progesterone (P4) were measured twice weekly and beta-hydroxybutyrate (BHBA), non-esterified fatty acids, thyroxine (T4), 3,30,5-tri-iodothyronine (T3), free thyroxine (fT4) and free 3,30,5-tri-iodothyronine (fT3) were measured every 2 weeks from the 1st to the 8th week postpartum. On the basis of the serum P4 profile of the cows, 25 (33.4%) had normal luteal activity (NLA), whereas 30 (40%), 10 (13.3%), 6 (8%) and 4 (5.3%) had prolonged luteal phase (PLP), delayed first ovulation (DOV), anovulation (AOV) and short luteal phase, respectively. Serum T4 concentrations in PLP cows were higher than that in NLA cows at the 3rd week postpartum and did not change during the period of study, whereas in the NLA cows the concentrations increased (P < 0.05). Further, the least square (LS) mean of serum fT4 concentrations in the DOV and AOV cows were significantly lower than in the NLA cows during the study period (P < 0.05). In addition, the AOV cows had higher LS mean serum BHBA and T4 concentrations than the NLA cows in early weeks postpartum (P < 0.05). In conclusion, the serum thyroid hormones’ profile differs in high-producing dairy cows showing PLP, AOV and DOV in comparison with the postpartum NLA cows.

Keywords

thyroid hormoneenergy metaboliteluteal activityhigh-producing dairy cow
Type
Full Paper
Information
animal , Volume 6 , Issue 8 , August 2012 , pp. 1253 - 1260
Copyright
Copyright © The Animal Consortium 2012

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References

Anderson, GM, Connors, JM, Hardy, SL, Valent, M, Goodman, RL 2002. Thyroid hormones mediate steroid-independent seasonal changes in luteinizing hormone pulsatility in the ewe. Biology of Reproduction 66, 701–706.CrossRefGoogle ScholarPubMed
Beam, SW, Butler, WR 1999. Effects of energy balance on follicular development and first ovulation in postpartum dairy cows. Journal of Reproduction and Fertility Supplement 54, 411–424.Google ScholarPubMed
Braw-Tal, R, Pen, S, Roth, Z 2009. Ovarian cysts in high-yielding dairy cows. Theriogenology 72, 690–698.CrossRefGoogle ScholarPubMed
Butler, WR 2000. Nutritional interactions with reproductive performance in dairy cattle. Animal Reproduction Science 60–61, 449–457.CrossRefGoogle ScholarPubMed
Capuco, AV, Keys, JE, Smith, JJ 1989. Somatotrophin increases thyroxine-5′-monodeiodinase activity in lactating mammary tissue of the cow. Journal of Endocrinology 121, 205–211.CrossRefGoogle ScholarPubMed
Capuco, AV, Wood, DL, Elsasser, TH, Kahl, S, Erdman, RA, Van Tassell, CP, Lefcourt, A, Piperova, LS 2001. Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake. Journal of Dairy Science 84, 2430–2439.CrossRefGoogle ScholarPubMed
De Moraes, GV, Vera-Avila, HR, Lewis, AW, Koch, JW, Neuendorff, DA, Hallford, DM, Reeves, JJ, Randel, RD 1998. Influence of hypo- or hyperthyroidism on ovarian function in Brahman cows. Journal of Animal Science 76, 871–879.CrossRefGoogle ScholarPubMed
Eryavuz, A, Avci, G, Kucukkurt, I, Fidan, AF 2007. Comparison of plasma leptin, insulin and thyroid hormone concentrations and some biochemical parameters between fat-tailed and thin-tailed sheep breeds. Revue de Medecine Veterinaire 158, 244–249.Google Scholar
Ferguson, JD, Galligan, DT, Thomsen, N 1994. Principal descriptors of body condition score in Holstein cows. Journal of Dairy Science 77, 2695–2703.CrossRefGoogle ScholarPubMed
Flores, R, Looper, ML, Rorie, RW, Hallford, DM, Rosenkrans, CF Jr 2008. Endocrine factors and ovarian follicles are influenced by body condition and somatotropin in postpartum beef cows. Journal of Animal Science 86, 1335–1344.CrossRefGoogle ScholarPubMed
Flores, R, Looper, ML, Rorie, RW, Lamb, MA, Reiter, ST, Hallford, DM, Kreider, DL, Rosenkrans, CF Jr 2007. Influence of body condition and bovine somatotropin on estrous behavior, reproductive performance, and concentrations of serum somatotropin and plasma fatty acids in postpartum Brahman-influenced cows. Journal of Animal Science 85, 1318–1329.CrossRefGoogle ScholarPubMed
Gautam, G, Nakao, T, Yamada, K, Yoshida, C 2010. Defining delayed resumption of ovarian activity postpartum and its impact on subsequent reproductive performance in Holstein cows. Theriogenology 73, 180–189.CrossRefGoogle ScholarPubMed
Gerloff, BJ, Herdt, TH, Wells, WW, Nachreiner, RF, Emery, RS 1986. Inositol and hepatic lipidosis. II. Effect of inositol supplementation and time from parturition on serum insulin, thyroxine and triiodothyronine and their relationship to serum and liver lipids in dairy cows. Journal of Animal Science 62, 1693–1702.CrossRefGoogle ScholarPubMed
Hanzen, CH, Pieterse, M, Scenczi, O, Drost, M 2000. Relative accuracy of the identification of ovarian structures in the cow by ultrasonography and palpation per rectum. Veterinary Journal 159, 161–170.CrossRefGoogle ScholarPubMed
Hapon, MB, Motta, AB, Ezquer, M, Bonafede, M, Jahn, GA 2007. Hypothyroidism prolongs corpus luteum function in the pregnant rat. Reproduction 133, 197–205.CrossRefGoogle ScholarPubMed
Horan, B, Mee, JF, O'Connor, P, Rath, M, Dillon, P 2005. The effect of strain of Holstein–Friesian cow and feeding system on postpartum ovarian function, animal production and conception rate to first service. Theriogenology 63, 950–971.CrossRefGoogle ScholarPubMed
Huszenicza, G, Kulcsár, M, Kóródi, P, Bartyik, J, Rudas, P, Ribiczei-Szabó, P, Nikolić-Judith, A, Šamanc, H, Ivanov, I, Gvozdić, D 2006. Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis. Acta Veterinaria 56, 25–36.Google Scholar
Huszenicza, GY, Kulcsár, M, Rudas, P 2002. Clinical endocrinology of thyroid gland function in ruminants: a review of literature. Veterinární Medicína 47, 191–202.Google Scholar
Kafi, M, Mirzaei, A 2010. Effects of first postpartum progesterone rise, metabolites, milk yield and body condition score on the subsequent ovarian activity and fertility in lactating Holstein dairy cows. Tropical Animal Health and Production 42, 761–767.CrossRefGoogle ScholarPubMed
Kimura, T, Nakanishi, K, Nakagawa, T, Shibukawa, A, Matsuzaki, K 2005. Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 38, 204–209.CrossRefGoogle ScholarPubMed
Laurberg, P, Vestergaard, H, Nielsen, S, Christensen, SE, Seefeldt, T, Helleberg, K, Pedersen, KM 2007. Sources of circulating 3,5,3′-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases. Journal of Clinical Endocrinology and Metabolism 92, 2149–2156.CrossRefGoogle ScholarPubMed
Lucy, MC 2003. Mechanisms linking nutrition and reproduction in postpartum cows. Reproduction Supplement 61, 415–427.Google ScholarPubMed
McCoya, MA, Lennoxa, SD, Maynea, CS, McCaugheya, WJ, Edgara, HWJ, Catneya, DC, Vernera, M, Mackeya, DR, Gordona, AW 2006. Milk progesterone profiles and their relationship with fertility, production and disease in dairy cows in Northern Ireland. Animal Science 82, 213–222.CrossRefGoogle Scholar
Mirzaei, A, Kafi, M, Ghavami, M, Mohri, M, Gheisari, HR 2007. Ovarian activity in high and average producing Holstein cows under heat stress conditions. Comparative Clinical Pathology 16, 235–241.CrossRefGoogle Scholar
Mohebbi-Fani, M, Nazifi, S, Rowghani, E, Bahrami, S, Jamshidi, O 2009. Thyroid hormones and their correlations with serum glucose, beta hydroxybutyrate, nonesterified fatty acids, cholesterol, and lipoproteins of high-yielding dairy cows at different stages of lactation cycle. Comparative Clinical Pathology 18, 211–216.CrossRefGoogle Scholar
Moreno, M, de Lange, P, Lombardi, A, Silvestri, E, Lanni, A, Goglia, F 2008. Metabolic effects of thyroid hormone derivatives. Thyroid 18, 239–253.CrossRefGoogle ScholarPubMed
Novoselec, J, Antunović, Z, Šperanda, M, Steiner, Z, Šperanda, T 2009. Changes of thyroid hormones concentration in blood of sheep depending on age and reproductive status. Italian Journal of Animal Science 8, 208–210.CrossRefGoogle Scholar
Opsomer, G, Coyyn, M, Deluyker, H, de Kruif, A 1998. An analysis of ovarian dysfunction in high yielding dairy cows after calving based on progesterone profiles. Reproduction in Domestic Animals 33, 193–204.CrossRefGoogle Scholar
Opsomer, G, Gröhn, YT, Hertl, J, Coryn, M, Deluyker, H, de Kruif, A 2000. Risk factors for post partum ovarian dysfunction in high producing dairy cows in Belgium: a field study. Theriogenology 53, 841–857.CrossRefGoogle ScholarPubMed
Patton, J, Kenny, DA, McNamara, S, Mee, JF, O'Mara, FP, Diskin, MG, Murphy, JJ 2007. Relationships among milk production, energy balance, plasma analytes, and reproduction in Holstein–Friesian cows. Journal of Dairy Science 90, 649–658.CrossRefGoogle ScholarPubMed
Pezzi, C, Accorsi, PA, Vigo, D, Govoni, N, Gaiani, R 2003. 5′-Deiodinase activity and circulating thyronines in lactating cows. Journal of Dairy Science 86, 152–158.CrossRefGoogle ScholarPubMed
Pryce, JE, Coffey, MP, Simm, G 2001. The relationship between body condition score and reproductive performance. Journal of Dairy Science 84, 1508–1515.CrossRefGoogle ScholarPubMed
Reist, M, Erdin, DK, von Euw, D, Tschümperlin, KM, Leuenberger, H, Hammon, HM, Morel, C, Philipona, C, Zbinden, Y, Künzi, N, Blum, JW 2003. Postpartum reproductive function: association with energy, metabolic and endocrine status in high yielding dairy cows. Theriogenology 59, 1707–1723.CrossRefGoogle ScholarPubMed
Rhodes, FM, McDougall, S, Burke, CR, Verkerk, GA, Macmillan, KL 2003. Invited review: treatment of cows with an extended postpartum anestrous interval. Journal of Dairy Science 86, 1876–1894.CrossRefGoogle ScholarPubMed
Richards, MW, Spicer, LJ, Wettemann, RP 1995. Influence of diet and ambient temperature on bovine serum insulin-like growth factor-I and thyroxine: relationships with non-esterified fatty acids, glucose, insulin, luteinizing hormone and progesterone. Animal Reproduction Science 37, 267–279.CrossRefGoogle Scholar
Shih, JL, Agus, MSD 2009. Thyroid function in the critically ill newborn and child. Current Opinion in Pediatrics 21, 536–540.CrossRefGoogle ScholarPubMed
Shrestha, HK, Nakao, T, Higaki, T, Suzuki, T, Akita, M 2004. Resumption of postpartum ovarian cyclicity in high-producing Holstein cows. Theriogenology 61, 637–649.CrossRefGoogle ScholarPubMed
Shrestha, HK, Nakao, T, Suzuki, T, Akita, M, Higaki, T 2005. Relationships between body condition score, body weight, and some nutritional parameters in plasma and resumption of ovarian cyclicity postpartum during pre-service period in high-producing dairy cows in a subtropical region in Japan. Theriogenology 64, 855–866.CrossRefGoogle Scholar
Spicer, LJ, Alonso, J, Chamberlain, CS 2001. Effects of thyroid hormones on bovine granulosa and thecal cell function in vitro: dependence on insulin and gonadotropins. Journal of Dairy Science 84, 1069–1076.CrossRefGoogle ScholarPubMed
Stevenson, JS 1997. Clinical reproductive physiology of the cow. In Current therapy in large animal theriogenology (ed. RS Younquist), pp. 257–267. WB Saunders, Philadelphia.Google Scholar
Viguié, C, Battaglia, DF, Krasa, HB, Thrun, LA, Karsch, FJ 1999. Thyroid hormones act primarily within the brain to promote the seasonal inhibition of luteinizing hormone secretion in the ewe. Endocrinology 140, 1111–1117.CrossRefGoogle ScholarPubMed
Wathes, DC, Fenwick, M, Cheng, Z, Bourne, N, Llewellyn, S, Morris, DG, Kenny, D, Murphy, J, Fitzpatrick, R 2007. Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow. Theriogenology 68 (Suppl 1), S232–S241.CrossRefGoogle ScholarPubMed
Weigel, KA 2006. Prospects for improving reproductive performance through genetic selection. Animal Reproduction Science 96, 323–330.CrossRefGoogle ScholarPubMed
Yen, PM 2001. Physiological and molecular basis of thyroid hormone action. Physiological Reviews 81, 1097–1142.CrossRefGoogle ScholarPubMed