Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-23T03:54:31.888Z Has data issue: false hasContentIssue false
  • English
  • Français

Polymorphisms in the autosomal genes for mitochondrial function TFAM and UCP2 are associated with performance and longevity in dairy cows

Published online by Cambridge University Press:  11 March 2011

A. M. Clempson ,
G. E. Pollott ,
J. S. Brickell ,
N. E. Bourne ,
N. Munce  and
D. C. Wathes
A. M. Clempson
Affiliation:
Department of Veterinary Basic Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
G. E. Pollott
Affiliation:
Department of Veterinary Basic Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
J. S. Brickell
Affiliation:
Department of Veterinary Basic Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
N. E. Bourne
Affiliation:
Department of Veterinary Basic Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
N. Munce
Affiliation:
Merial Animal Health Ltd, Sandringham House, Harlow Business Park, Harlow, Essex, CM19 5TG, UK
D. C. Wathes*
Affiliation:
Department of Veterinary Basic Science, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
*
†E-mail: [email protected]
Get access

Abstract

The autosomal genes mitochondrial transcription factor A (TFAM) and uncoupling protein 2 (UCP2) are both involved in moderating mitochondrial energy production. This study investigated single nucleotide polymorphisms (SNPs) in TFAM and UCP2 and their associations with growth, fertility, milk production and survival in UK dairy cows. Holstein–Friesian heifers (n = 509) were recruited at birth and monitored until they either reached the end of their second lactation or were culled. Weight, height, length and girth were measured at 1, 6 and 15 months of age to assess growth. Fertility records were obtained for both heifers and cows and production traits (milk per day, peak yield and 305-day yield) were recorded in the first and second lactation. Mixed model and survival analyses revealed that TFAM3 GG homozygotes, representing 49% of the population, were larger than the AG heterozygotes throughout the growing period, had worse fertility, produced less milk in both lactations and were more likely to be culled. TFAM3 AA homozygotes (7% of population) were generally smaller as heifers, had slightly worse fertility and also produced less milk. This suggests a clear advantage for maximizing the heterozygotic population for this SNP. Furthermore, the results for milk per day suggest an overdominant effect, as both homozygotes of TFAM3 had significantly lower yields than the heterozygote. For UCP2, the minority CG heterozygotes (6% of population) were larger as heifers, had a reduced age at first conception and a delayed return to cyclicity after calving, when compared against the majority (94%) GG homozygotes.

Keywords

SNPmitochondriagrowthfertilitysurvival
Type
Full Paper
Information
animal , Volume 5 , Issue 9 , 05 August 2011 , pp. 1335 - 1343
Copyright
Copyright © The Animal Consortium 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barrett, J, Fry, B, Maller, J, Daly, M 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.CrossRefGoogle ScholarPubMed
Beam, S, Butler, W 1999. Effects of energy balance on follicular development and first ovulation in postpartum dairy cows. Journal of Reproduction and Fertility (suppl. 54), 411–424.Google ScholarPubMed
Brickell, J, Bourne, N, McGowan, M, Wathes, DC 2009a. Effect of growth and development during the rearing period on the subsequent fertility of nulliparous Holstein–Friesian heifers. Theriogenology 72, 408–416.CrossRefGoogle ScholarPubMed
Brickell, J, McGowan, M, Wathes, DC 2009b. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms. Domestic Animal Endocrinology 36, 67–81.CrossRefGoogle ScholarPubMed
Bulman, DC, Lamming, G 1978. Milk progesterone levels in relation to conception repeat breeding and factors influencing acyclicity in dairy cows. Journal of Reproduction and Fertility 54, 447–458.CrossRefGoogle ScholarPubMed
Donovan, G, Bennett, F, Springer, F 2003. Factors associated with first service conception in artificially inseminated nulliparous Holstein heifers. Theriogenology 60, 67–75.CrossRefGoogle ScholarPubMed
Echtay, K 2007. Mitochondrial uncoupling proteins – what is their physiological role? Free Radical Biology and Medicine 43, 1351–1371.CrossRefGoogle ScholarPubMed
Ettema, J, Santos, J 2004. Impact of age at calving on lactation reproduction health and income in first-parity Holsteins on commercial farms. Journal of Dairy Science 87, 2730–2742.CrossRefGoogle ScholarPubMed
Fleury, C, Neverova, M, Collins, S, Raimbault, S, Champigny, O, Levi-Meyrueis, C, Bouillaud, F, Seldin, M, Surwit, R, Ricquier, D, Warden, C 1997. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15, 269–272.CrossRefGoogle ScholarPubMed
Freeman, G, Halton, J 1951. Note on an exact treatment of contingency goodness of fit and other problems of significance. Biometrika 38, 141–149.CrossRefGoogle Scholar
Garnsworthy, P 2004. The environmental impact of fertility in dairy cows: a modelling approach to predict methane and ammonia emissions. Animal Feed Science and Technology 112, 211–223.CrossRefGoogle Scholar
Gilmour, A, Gogel, B, Cullis, B, Thompson, R 2006. ASREML user guide, release 2.0. VSN International Ltd, Hemel Hempstead, UK.Google Scholar
Hare, E, Norman, HD, Wright, JR 2006. Survival rates and productive herd life of dairy cattle in the United States. Journal of Dairy Science 89, 3713–3720.CrossRefGoogle ScholarPubMed
Haworth, G, Tranter, W, Chuck, J, Cheng, Z, Wathes, DC 2008. Relationships between age at first calving and first lactation milk yield and lifetime productivity and longevity in dairy cows. Veterinary Record 162, 643–647.CrossRefGoogle ScholarPubMed
Holloway, G, Bonen, A, Spriet, L 2009. Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals. American Journal of Clinical Nutrition 89, 455–462.CrossRefGoogle ScholarPubMed
Jagannatha, S, Keown, J, Van Vleck, L 1998. Estimation of relative economic value for herd life of dairy cattle from profile equations. Journal of Dairy Science 81, 1702–1708.CrossRefGoogle ScholarPubMed
Jia, J, Zhang, X, Ge, C, Jois, M 2009. The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism obesity and diabetes. Obesity Reviews 10, 519–526.CrossRefGoogle ScholarPubMed
Jiang, Z, Kunej, T, Michal, J, Gaskins, C, Reeves, J, Busboom, J, Dovc, P, Wright, R Jr 2005. Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu × Limousin F2 crosses. Biochemical and Biophysical Research Communications 334, 516–523.CrossRefGoogle ScholarPubMed
Jiang, Z, Kunej, T, Wibowo, T, Michal, J, Zhang, Z, Gaskins, C, Reeves, J, Busboom, J, Dovc, P, Wright, R Jr 2006. The basal nucleus-encoded mitochondrial transcription genes and meat quality in beef cattle. In Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, 13–18 August 2006, Belo Horizonte, Brazil, pp. 22–24.Google Scholar
Klassen, D, Monardes, H, Jairath, L, Cue, R, Hayes, J 1992. Genetic correlations between lifetime production and linearized type in Canadian Holsteins. Journal of Dairy Science 75, 2272–2282.CrossRefGoogle ScholarPubMed
Kolath, W, Kerley, M, Golden, J, Keisler, D 2006. The relationship between mitochondrial function and residual feed intake in Angus steers. Journal of Animal Science 84, 861–865.CrossRefGoogle ScholarPubMed
Kossaibati, M, Esslemont, R 1997. The cost of respiratory diseases in dairy heifer calves. The Bovine Practitioner 33, 174–178.Google Scholar
May-Panloup, P, Vignon, X, Chretien, M, Heyman, Y, Tamassia, M, Malthiery, Y, Reynier, P 2005. Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors. Reproductive Biology and Endocrinology 3, 65–72.CrossRefGoogle ScholarPubMed
Mosig, M, Lipkin, E, Khutoreskaya, G, Tchourzyna, E, Soller, M, Friedmann, A 2001. A whole genome scan for quantitative trait loci affecting milk protein percentage in Israeli-Holstein cattle by means of selective milk DNA pooling in a daughter design using an adjusted false discovery rate criterion. Genetics 157, 1683–1698.CrossRefGoogle Scholar
Sherman, E, Nkrumah, J, Murdoch, B, Li, C, Wang, Z, Fu, A, Moore, S 2008. Polymorphisms and haplotypes in the bovine neuropeptide Y growth hormone receptor ghrelin insulin-like growth factor 2 and uncoupling proteins 2 and 3 genes and their associations with measures of growth performance feed efficiency and carcass merit in beef cattle. Journal of Animal Science 86, 1–16.CrossRefGoogle ScholarPubMed
Veerkamp, R, Koenen, E, De Jong, G 2001. Genetic correlations among body condition score yield and fertility in first-parity cows estimated by random regression models. Journal of Dairy Science 84, 2327–2335.CrossRefGoogle ScholarPubMed
Wathes, DC, Brickell, J, Bourne, N, Swali, A, Cheng, Z 2008. Factors influencing heifer survival and fertility on commercial dairy farms. Animal 2, 1135–1143.CrossRefGoogle ScholarPubMed
Wathes, DC, Fenwick, M, Cheng, Z, Bourne, N, Llewellyn, S, Morris, D, Kenny, D, Murphy, J, Fitzpatrick, R 2007. Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow. Theriogenology 68 (suppl. 1), 232–241.CrossRefGoogle ScholarPubMed
Zhang, CY, Baffy, G, Perret, P, Krauss, S, Peroni, O, Grujic, D, Hagen, T, Vidal-Puig, AJ, Boss, O, Kim, YB, Zheng, XX, Wheeler, MB, Shulman, GI, Chan, CB, Lowell, BB 2001. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity beta cell dysfunction and type 2 diabetes. Cell 105, 745–755.CrossRefGoogle Scholar