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Evaluation of the effects of pharmacological zinc oxide and phosphorus source on weaned piglet growth performance, plasma minerals and mineral digestibility

Published online by Cambridge University Press:  02 March 2015

C. L. Walk ,
P. Wilcock  and
E. Magowan
C. L. Walk*
Affiliation:
AB Vista Feed Ingredients, Marlborough, SN8 4AN, United Kingdom
P. Wilcock
Affiliation:
AB Vista Feed Ingredients, Marlborough, SN8 4AN, United Kingdom
E. Magowan
Affiliation:
Agri-food and Biosciences Institute, Hillsborough, BT26 6DR, United Kingdom
*
†E-mail: [email protected]
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Abstract

Crossbred pigs (n=720; average age=28±3 days and weight=9.5±0.3 kg) were used in a 20-day trial in order to determine the influence of phosphorus (P) source and various doses of pharmacological zinc (Zn) on growth performance, plasma minerals and mineral digestibility. Pigs (five intact males and five females per pen) were randomly allotted to treatments in a 3×3 factorial arrangement with three sources of dietary P (4.5 g/kg digestible P, 4.5 g/kg digestible P plus 2500 phytase units (FTU)/kg, or 5.5 g/kg digestible P) and three dietary levels of supplemental Zn (0, 1750 or 3500 mg/kg) from ZnO (82% Zn) with eight pens per treatment. Diets were formulated to exceed all nutrient requirements, including calcium (Ca), P and Zn from day 0 to 20. Zn supplementation increased (quadratic P<0.05) average daily feed intake. There was a significant Zn level×P source interaction on average daily gain and feed conversion ratio (FCR). Pigs fed 4.5 g/kg digestible P without or with 2500 FTU/kg phytase gained more per day (quadratic P<0.05) and had better FCR (quadratic P<0.05) when they were fed 1750 mg/kg supplemental Zn. However, pigs fed 5.5 g/kg digestible P gained more per day (linear P<0.05) and were more efficient (linear P<0.05) when they were fed 3500 mg/kg supplemental Zn. Plasma Zn and Zn digestibility increased (linear P<0.05) as pharmacological Zn supplementation increased from 0 to 3500 mg/kg, irrespective of P source. However, Ca, P, sodium (Na), potassium (K) and copper (Cu) digestibility were reduced (P<0.05) as pharmacological Zn supplementation increased, and this was mitigated or exacerbated by the supplementation of 5.5 g/kg digestible P or phytase. In conclusion, increasing the dietary inclusion of pharmacological Zn may impact growth performance in young pigs through the interaction with minerals such as Ca, P, Na and K. Pharmacological Zn may reduce Na or K digestibility and indirectly reduce water secretion into the lumen, resulting in an increase in faecal dry matter as pharmacological Zn supplementation in the diet increased.

Keywords

mineralsphosphorusphytasepigzinc oxide
Type
Research Article
Information
animal , Volume 9 , Issue 7 , July 2015 , pp. 1145 - 1152
Copyright
© The Animal Consortium 2015 

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References

Adeola, O, Lawrence, BV, Sutton, AL and Cline, TR 1995. Phytase-induced changes in mineral utilization in zinc-supplemented diets for pigs. Journal of Animal Science 73, 3384–3391.Google Scholar
Augspurger, NR, Spencer, JD, Webel, DM and Baker, DH 2004. Pharmacological zinc levels reduce the phosphorus-releasing efficacy of phytase in young pigs and chickens. Journal of Animal Science 82, 1732–1739.Google Scholar
Berkes, J, Viswanathan, VK, Savkovic, SD and Hecht, G 2003. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport and inflammation. Gut 52, 439–451.Google Scholar
Buff, CE, Bollinger, DW, Ellersieck, MR, Brommelsiek, WA and Veum, TL 2005. Comparison of growth performance and zinc absorption, retention, and excretion in weanling pigs fed diets supplemented with zinc-polysaccharide or zinc oxide. Journal of Animal Science 83, 2380–2386.Google Scholar
Cabell, CA and Earle, IP 1965. Additive effect of calcium and phosphorus on utilization of dietary zinc. Journal of Animal Science 24, 800–804.Google Scholar
Carlson, MS, Hill, GM and Link, JE 1999. Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations. Journal of Animal Science 77, 1199–1207.CrossRefGoogle ScholarPubMed
Champagne, ET and Phillippy, BQ 1989. Effects of pH on calcium, zinc, and phytate solubilities and complexes following in vitro digestions of soy protein isolate. Journal of Food Science 54, 587–592.CrossRefGoogle Scholar
Champagne, ET, Fisher, MS and Hinojosa, O 1990. NMR and ESR studies of interactions among divalent cations, phytic acid, and N-acetyl-amino acids. Journal of Inorganic Biochemistry 38, 199–215.Google Scholar
Engelen, AJ, van der Heeft, FC, Randsdorp, HG and Somers, WAC 2001. Determination of phytase activity in feed by a colorimetric enzymatic method: collaborative interlaboratory study. Journal of AOAC International 84, 629–633.Google Scholar
Gifford, SR and Clydesdale, FM 1990. Interactions among calcium, zinc, and phytate with three protein sources. Journal of Food Science 55, 1720–1724.Google Scholar
Hahn, JD and Baker, DH 1993. Growth and plasma zinc responses of young pigs fed pharmacological levels of zinc. Journal of Animal Science 71, 3020–3024.Google Scholar
Hill, GM, Mahan, DC, Carter, SD, Cromwell, GL, Ewan, RC, Harrold, RL, Lewis, AJ, Miller, PS, Shurson, GC and Veum, TL 2001. Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. Journal of Animal Science 79, 934–941.Google Scholar
Hoque, KM, Rajendran, VM and Binder, HJ 2005. Zinc inhibits cAMP-stimulate Cl secretion via basolateral K-channel blockade in rat ileum. American Journal of Physiology Gasterointestinal and Liver Physiology 288, G956–G963.Google Scholar
Kies, AK, Kemme, PA, Sebek, LBJ, Diepen, JTM and Jongbloed, AW 2006. Effect of graded doses and a high dose of microbial phytase on the digestibility of various minerals in weaner pigs. Journal of Animal Science 84, 1169–1175.Google Scholar
Martinez, MM, Link, JE and Hill, GM 2005. Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig. Biological Trace Element Research 105, 97–115.CrossRefGoogle ScholarPubMed
Meyer, TA, Lindemann, MD, Cromwell, GL, Monegue, HJ and Inocencio, N 2002. Effects of pharmacological levels of zinc as zinc oxide on fecal zinc and mineral excretion in weanling pigs. The Professional Animal Scientists 18, 162–168.Google Scholar
National Research Council 1998. Nutrient requirements of swine, 10th revised edition National Academy Press, Washington, DC, USA.Google Scholar
Petersen, GI, Pedersen, C, Lindemann, MD and Stein, HH 2011. Relative bioavailability of phosphorus in inorganic phosphorus sources fed to growing pigs. Journal of Animal Science 89, 460–466.CrossRefGoogle ScholarPubMed
Revy, PS, Jondreville, C, Dourmad, JY and Nys, Y 2004. Effect of zinc supplemented as either an organic or inorganic source of microbial phytase on zinc and other minerals utilisation by weanling pigs. Animal Feed Science and Technology 116, 93–112.Google Scholar
Shelton, NW, Tokach, MD, Nelssen, JL, Goodband, RD, Dritz, SS, DeRouchey, JM and Hill, GM 2011. Effects of copper sulfate, tri-basic copper chloride, and zinc oxide on weanling pig performance. Journal of Animal Science 89, 2440–2451.Google Scholar
Short, FJ, Gorton, P, Wiseman, J and Boorman, KN 1996. Determination of titanium dioxide added as an inert marker in chicken digestibility studies. Animal Feed Science and Technology 59, 215–221.Google Scholar
Simpson, CJ and Wise, A 1990. Binding of zinc and calcium to inositol phosphates (phytate) in vitro. Journal of Nutrition 64, 225–232.Google Scholar
Walk, CL, Srinongkote, S and Wilcock, P 2013. Influence of a microbial phytase and zinc oxide on young pig growth performance and serum minerals. Journal of Animal Science 91, 286–291.CrossRefGoogle Scholar
Wellock, IJ, Fortomaris, PD, Houdijk, JGM and Kyriazakis, I 2006. The effect of dietary protein supply on the performance and risk of post-weaning enteric disorders in newly weaned pigs. Animal Science 82, 327–335.Google Scholar
Zemel, MB and Bidari, MT 1983. Zinc, iron and copper availability as affected by orthophosphates, polyphosphates and calcium. Journal of Food Science 48, 567–569.CrossRefGoogle Scholar