Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-25T14:38:29.812Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of inulin and lactulose on the intestinal morphology of calves

Published online by Cambridge University Press:  13 January 2010

S. Masanetz ,
N. Wimmer ,
C. Plitzner ,
E. Limbeck ,
W. Preißinger  and
M. W. Pfaffl
S. Masanetz*
Affiliation:
Chair of Physiology, Research Center for Nutrition and Food Sciences (ZIEL), Technical University of Munich, D-85354 Freising, Germany
N. Wimmer
Affiliation:
Chair of Physiology, Research Center for Nutrition and Food Sciences (ZIEL), Technical University of Munich, D-85354 Freising, Germany
C. Plitzner
Affiliation:
University of Natural Resources and Applied Life Sciences, Division of Animal Food and Nutrition, A-1180 Vienna, Austria
E. Limbeck
Affiliation:
Chair of Physiology, Research Center for Nutrition and Food Sciences (ZIEL), Technical University of Munich, D-85354 Freising, Germany
W. Preißinger
Affiliation:
Bavarian State Research Centre for Agriculture (LfL), D-85586 Poing-Grub, Germany
M. W. Pfaffl
Affiliation:
Chair of Physiology, Research Center for Nutrition and Food Sciences (ZIEL), Technical University of Munich, D-85354 Freising, Germany
*
†E-mail: [email protected]
Get access

Abstract

For some time now prebiotics have been proposed to improve health by stimulation of beneficial bacteria in the intestine of humans and animals. The current study is aiming to show effects of feeding of either 2% inulin or 2% lactulose in milk replacer on performance and intestinal morphology of male Holstein–Friesian calves. After 20 weeks of feeding inulin led to significantly higher daily weight gains than lactulose while control animals ranged between the experimental feedings. Ingestion of milk replacer was reduced in lactulose treated animals. Additionally differences of villus height in jejunum (P = 0.07) and ileum (P = 0.03) could be found with an increase for lactulose treated animals and a decrease for inulin treated animals. In ileum the density of proliferative epithelial cells tended to be lower in inulin treated and higher in lactulose treated animals (P = 0.08). Both inulin and lactulose tended to decrease the quantity of goblet cells in the tips of ileal villi (P = 0.07). Both prebiotics can affect performance and intestinal morphology of calves and may as such affect animal health. But effects differ between substances.

Keywords

calvesintestineinulinlactulosemorphologyprebiotics
Type
Full Paper
Information
animal , Volume 4 , Issue 5 , May 2010 , pp. 739 - 744
Copyright
Copyright © The Animal Consortium 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Altman, DG 1985. Comparability of randomised groups. The Statistician 34, 125–140.CrossRefGoogle Scholar
Attar, A, Lemann, M, Ferguson, A, Halphen, M, Boutron, M-C, Flourie, B, Alix, E, Salmeron, M, Guillemot, F, Chaussade, S, Menard, A-M, Moreau, J, Naudin, G, Barthet, M 1999. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 44, 226–230.CrossRefGoogle ScholarPubMed
Awad, W, Ghareeg, K, Böhm, J 2008. Intestinal structure and function of broiler chickens on diets supplemented with a synbiotic containing Enterococcus faecium and oligosaccharides. International Journal of Molecular Sciences 9, 2205–2216.CrossRefGoogle ScholarPubMed
Bircher, J, Müller, J, Guggenheim, P, Haemmerli, UP 1966. Treatment of chronic portal-systemic encephalopathy with lactulose. The Lancet 287, 890–893.Google Scholar
Branner, GR, Böhmer, BM, Erhardt, W, Henke, J, Roth-Maier, DA 2004. Investigation on the precaecal and faecal digestibility of lactulose and inulin and their influence on nutrient digestibility and microbial characteristics. Archives of Animal Nutrition 58, 353–366.CrossRefGoogle ScholarPubMed
Brunsgaard, G, Eggum, BO 1995. Caecal and colonic tissue structure and proliferation as influenced by adaption period and indigestible polysaccharides. Comparative Biochemistry and Physology – Part A: Physiology 112, 573–583.CrossRefGoogle Scholar
Clarke, RM 1975. The time-course of changes in mucosal architecture and epithelial cell production and cell shedding in the small intestine of the rat fed after fasting. Journal of Anatomy 120, 321–327.Google ScholarPubMed
Claus, R, Günthner, D, Letzguß, H 2006. Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig. Journal of Animal Physiology and Animal Nutrition 91, 312–318.CrossRefGoogle Scholar
Femia, AP, Luceri, C, Dolara, P, Giannini, A, Biggeri, A, Salvadori, M, Clune, Y, Collins, KJ, Paglierani, M, Caderni, G 2002. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxy-methane-induced colon carcinogenesis in rats. Carcinogenesis 23, 1953–1960.CrossRefGoogle ScholarPubMed
Fleige, S, Preißinger, W, Meyer, HHD, Pfaffl, MW 2007. Effect of lactulose on growth performance and intestinal morphology of pre-ruminant calves using a milk replacer containing Enterococcus faecium. Animal 1, 367–373.CrossRefGoogle ScholarPubMed
Flickinger, EA, van Loo, J, Fahey, GC 2003. Nutritional responses to the presence of inulin and oligofructose in the diets of domesticated animals: a review. Critical Reviews in Food Science and Nutrition 43, 19–60.CrossRefGoogle Scholar
Gibson, GR, Beatty, ER, Wang, X, Cummings, JH 1995. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–982.CrossRefGoogle ScholarPubMed
Gibson, GR, Roberfroid, MB 1995. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of Nutrition 125, 1401–1412.CrossRefGoogle ScholarPubMed
Hughes, R, Rowland, IR 2001. Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon. Carcinogenesis 22, 43–47.CrossRefGoogle ScholarPubMed
Ito, H, Satsukawa, M, Arai, E, Sugiyama, K, Sonoyama, K, Kiriyama, S, Morita, T 2009. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. The Journal of Nutrition 139, 1640–1647.CrossRefGoogle ScholarPubMed
Kaufhold, J, Hammon, HM, Blum, JW 2000. Fructo-oligosaccharide supplementation: effects on metabolic, endocrine and hematological traits in veal calves. Journal of Veterinary Medicine, Series A 47, 17–29.CrossRefGoogle ScholarPubMed
Kim, M 2002. The water-soluble extract of chicory affects rat intestinal morphology similarly to other non-starch polysaccharides. Nutrition Research 22, 1299–1307.CrossRefGoogle Scholar
Mitsuoka, T, Hidaka, H, Eida, T 1987. Effect of fructo-oligosaccharides on intestinal microflora. Die Nahrung 31, 426–436.CrossRefGoogle ScholarPubMed
Pierce, KM, Sweeney, T, Brophy, PO, Callan, JJ, McCarty, P, O’Doherty, JV 2005. Dietary manipulation post weaning to improve piglet performance and gastro-intestinal health. Animal Science 81, 347–356.CrossRefGoogle Scholar
Preißinger, W, Büttel, C, Obermaier, A, Masanetz, S, Pfaffl, MW 2007. Inulin und Lactulose in der Kälbermast – Auswirkungen auf Futteraufnahme und Leistung. In Tagungsband. 6. BOKU-Symposium Tierernährung, Vienna, Austria, 15.11.2007, pp. 102–109.Google Scholar
Rycroft, CE, Jones, MR, Gibson, GR, Rastall, RA 2001. A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. Journal of Applied Microbiology 91, 878–887.CrossRefGoogle ScholarPubMed
Schumann, C 2002. Medical, nutritional and technological properties of lactulose. An update. European Journal of Nutrition 41 (suppl. 1), I/17–I/25.CrossRefGoogle ScholarPubMed
Sehm, J, Lindermayer, H, Dummer, C, Treutter, D, Pfaffl, MW 2006. The influence of polyphenol rich apple pomace or red-wine pomace diet on the gut morphology in weaning piglets. Journal of Animal Physiology and Animal Nutrition 91, 289–296.CrossRefGoogle Scholar
Van Loo, J 2007. How chicory fructans contribute to zootechnical performance and well-being I livestock and companion animals. The Journal of Nutrition 137, 2594S–2597S.CrossRefGoogle ScholarPubMed
Van Loo, J, Coussement, P, de Leenheer, L, Hoebregs, H, Smits, G 1995. On the presence of inulin and oligofructose as natural ingredients in the western diet. Critical Reviews in Food Science and Nutrition 35, 525–552.CrossRefGoogle ScholarPubMed
Van Nevel, CJ, Decuypere, JA, Dierick, NA, Molly, K 2005. Incorporation of galactomannans in the diet of newly weaned piglets: Effect on bacteriological and some morphological characteristics of the small intestine. Archives of Animal Nutrition 59, 123–138.CrossRefGoogle ScholarPubMed
Wu, G, Meier, SA, Knabe, DA 1996. Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs. The Journal of Nutrition 126, 2578–2584.CrossRefGoogle ScholarPubMed