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Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection

Published online by Cambridge University Press:  22 April 2016

Y. X. Liu ,
K. Y. Zhu ,
Y. L. Liu  and
D. F. Jiang
Y. X. Liu*
Affiliation:
College of Animal Husbandry Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, P. R. China
K. Y. Zhu
Affiliation:
College of Animal Husbandry Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, P. R. China
Y. L. Liu
Affiliation:
Henan Engineering Technology Research Center of Animal Nutrition and Feed, Zhengzhou 450046, Henan Province, P. R. China
D. F. Jiang
Affiliation:
Henan Engineering Technology Research Center of Animal Nutrition and Feed, Zhengzhou 450046, Henan Province, P. R. China
*
†E-mail: [email protected]
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Abstract

The present study investigated the effects of dietary conjugated linoleic acid (CLA) on the cellular immune response of piglets after cyclosporin A (CsA) treatment. The experimental study had a 2×2 factorial design, and the main factors consisted of diets (0% or 2% CLA) and immunosuppression treatments (CsA or saline injection). CsA injection significantly increased feed : gain (F : G) of piglets (P<0.05); however, dietary CLA significantly decreased F : G of piglets (P<0.05). Dietary CLA partly ameliorated the deterioration of the feed conversion rate caused by CsA treatment (P<0.01). CsA treatment significantly decreased the percentages of CD4+ and CD8+ T lymphocytes in the thymus (P<0.01). Dietary CLA increased the percentages of CD4+ CD8+ double-positive and CD8+ single-positive T lymphocytes in the thymus (P<0.05), and had the trend to inhibit the decrease of CD4+ T lymphocytes in the thymus after CsA injection (P=0.07). CsA treatment significantly depleted the peripheral blood CD3+, CD4+ and CD8+ T lymphocytes (P<0.01). Dietary CLA significantly increased the number of peripheral blood CD8+ T lymphocytes and interleukin-2 (IL-2) production (P<0.05), and inhibited the decreases of peripheral blood CD3+, CD4+ and CD8+ T lymphocytes counts (P<0.01) as well as IL-2 production (P<0.05) after CsA treatment. Dietary CLA partly rescued the decrease of lymphocyte proliferation after CsA injection (P<0.05). In summary, dietary CLA effectively ameliorated CsA-induced cellular immunosuppression in piglets.

Keywords

conjugated linoleic acidspigletcyclosporin Acellular immunity
Type
Research Article
Information
animal , Volume 10 , Issue 10 , October 2016 , pp. 1660 - 1665
Copyright
© The Animal Consortium 2016 

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