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Welfare Considerations with Regard to Transgenic Animals

Published online by Cambridge University Press:  11 January 2023

T B Poole
T B Poole*
Affiliation:
Universities Federation for Animal Welfare, 8 Hamilton Close, South Mimms, Potters Bar, Herts EN6 3QD, UK
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Transgenic animals are becoming increasingly important in laboratory animal science. They seem to offer many potential benefits for mankind particularly in the fields of immunology, teratology and our understanding of the role of specific genes in development. The advantages of using transgenic animals could be particularly important in disease control and in the production of biologically active substances. It may also be possible, by inducing a pathological condition simulating a human disease in, for example, a mouse, to avoid using a mammal higher in the phylogenetic scale which, through its closer relationship with man, might otherwise be the only available species showing the condition.

Type
Invited Essay
Information
Animal Welfare , Volume 4 , Issue 2 , May 1995 , pp. 81 - 85
Copyright
© 1995 Universities Federation for Animal Welfare

References

Bateson, P 1986 When to experiment on animals. New Scientist 109(1496): 30–32Google ScholarPubMed
Berlanga, J, Infante, J, Capo, V, Delafuente, J and Castro, F O 1993 Characterisation of transgenic mice lineages. 1. overexpression of hGH causes the formation of liver intranuclear pseudoinclusion bodies and renal and hepatic injury. Acta Biotechnologica 13: 361–371CrossRefGoogle Scholar
Brem, G and Wanke, R 1988 Phenotypic and patho-morphological characteristics in a half-sib-family of transgenic mice carrying foreign MT-hGH genes. In: Beynen, A C and Solleveld, H A (eds) New Developments in Biosciences: Their Implications for Laboratory Animal Science pp 93–98. Martinus Nijhoff: DordrechtCrossRefGoogle Scholar
Palmiter, R D, Brinster, R L, Hammer, R E, Trumbauer, M E, Rosenfeld, M G, Birnberg, N C and Evans, R M 1982 Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300: 611–615Google ScholarPubMed
Palmiter, R D, Norstedt, G, Genlinas, R E, Hammer, R E and Brinster, R L 1983 Metallothionein-Human GH fusion genes stimulate growth of mice. Science 222: 809–914CrossRefGoogle ScholarPubMed
Wanke, R, Folger, S, Hermanns, W, Wolf, E and Brem, G 1991 The GH-transgenic mouse as a model in nephrological and oncological research. In: Proceedings XXVth International Symposium on Biological Models p 66. Czech Society for Laboratory Animal Science: Spinderluv Mlyn: Czech RepublicGoogle Scholar