Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-23T15:02:24.588Z Has data issue: false hasContentIssue false
  • English
  • Français

Thyroid function as measured by 131iodine release rate, weight and RNA/DNA in growing lambs, and its relation to growth rate

Published online by Cambridge University Press:  02 September 2010

S. A. Draper ,
N. B. Haynes ,
I. R. Falconer  and
G. E. Lamming
S. A. Draper
Affiliation:
University of Nottingham, School of Agriculture, Sutton Bonington, Loughborough, Leics.
N. B. Haynes
Affiliation:
University of Nottingham, School of Agriculture, Sutton Bonington, Loughborough, Leics.
I. R. Falconer
Affiliation:
University of Nottingham, School of Agriculture, Sutton Bonington, Loughborough, Leics.
G. E. Lamming
Affiliation:
University of Nottingham, School of Agriculture, Sutton Bonington, Loughborough, Leics.
Get access

Summary

Thyroid activity was assessed in two groups of crossbred lambs and in Dorset Horn lambs fed ad libitum, by measuring the rate constant (K4) for the release of 131iodine from the gland. The results demonstrated a highly significant curvilinear correlation (P<0·001) between growth rate and the rate constant (K4) in experiments based on individual measurements in animals from three populations.

Separate work carried out on the measurements of both thyroid size and RNA/DNA ratio suggests a need for caution when these are interpreted as parameters of thyroid activity. In the growing animal these may be more reflective of the growth of the thyroid gland itself, differences which may be governed by factors not directly related to variations in hormone secretion rate.

The findings are discussed in terms of an explanation of the contradictory results obtained where attempts have been made to alter the thyroid status of growing animals by the use of thyroid hormone analogues and thyroid depressant drugs.

Type
Research Article
Information
Animal Production , Volume 11 , Issue 3 , August 1969 , pp. 399 - 407
Copyright
Copyright © British Society of Animal Science 1969

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Acevedo, R. I., Schweigert, B. S., Pearson, P. B. and Dahlberg, F. I. 1948. Effect of feeding thiouracil to swine, on the rate of gain and weight of the thyroid gland. J. Anim. Sci. 7: 214–221.CrossRefGoogle Scholar
Armstrong, D. T. and Hansel, W. 1956. The effect of age and plane of nutrition on growth hormone and thyrotrophic hormone content of pituitary glands of Holstein heifers. J. Anim. Sci. 15: 640–649.CrossRefGoogle Scholar
Barrick, E. R., Andrews, F. N. and Beeson, W. M. 1950. Physiological effects of thiouracil and similar drugs on sheep. J. Anim. Sci. 9: 387–403.CrossRefGoogle ScholarPubMed
Begg, D. J., McGirr, E. M. and Munro, H. N. 1965. Protein and nucleic acid content of the thyroid glands of different mammals. Endocrinology 76: 171–177.CrossRefGoogle ScholarPubMed
Creek, R. O. 1965. Effect of thyrotrophin on the weight, protein, ribonucleic acid and the radioactive phosphorus uptake of chick thyroids. Endocrinology 76: 1124–1133.CrossRefGoogle ScholarPubMed
Dinusson, W. E., Andrews, F. N. and Beeson, W. M. 1948. Effects of stilbestrol, testosterone and thyroid alterations on growth and fattening of beef heifers. J. Anim. Sci. 7: 523–524.Google Scholar
Dinusson, W. E., Andrews, F. N. and Beeson, W. M. 1950. The effects of stilbestrol, testosterone, thyroid alteration and spaying on the growth and fattening of beef heifers. J. Anim. Sci. 9: 321–330.CrossRefGoogle ScholarPubMed
Draper, S. A., Falconer, I. R. and Lamming, G. E. 1968. Thyroid activity and growth rate in rapidly growing lambs. J. Physiol, Lond. 197: 659–665.CrossRefGoogle ScholarPubMed
Drury, H. F. 1948. Identification and estimation of pentoses in the presence of glucose. Archs Biochem. 19: 455–466.Google ScholarPubMed
Falconer, I. R. 1966. Studies of the congenital goitrous sheep. Biochem. J. 100: 190–196.CrossRefGoogle ScholarPubMed
Falconer, I. R. and Robertson, H. A. 1961. Changes in thyroid activity during growth in the sheep. J. Endocr. 22: 23–30.CrossRefGoogle ScholarPubMed
Gawienowski, A. M., Mayer, D. T. and Lasley, J. F. 1955. The serum protein-bound iodine of swine as a measure of growth potentialities. J. Anim. Sci. 14: 3–6.CrossRefGoogle Scholar
Johnston, E. F., Ellis, N. R. and Winchester, C. F. 1956. The interaction of temperature and thiouracil feeding upon carcass characteristics and feeding characteristics of pigs. J. Anim. Sci. 15: 271–279.CrossRefGoogle Scholar
Kirton, A. H., Cresswell, E., Cockrem, F. R. and Butler, G. W. 1959. Some effects of thyroxine on liveweight, metabolism and wool growth of Romney ewes. N.Z. Jl agric. Res. 2: 1143–1158.CrossRefGoogle Scholar
Kline, E. A., Ensminger, M. E., Cunha, T. J., Heinemann, W. W. and Ham, W. E. 1949. Effect of adding drugs to the ration of fattening cattle. J. Anim. Sci. 8: 411–424.CrossRefGoogle Scholar
Kunkel, H. O., Colby, R. W. and Lyman, C. M. 1953. The relationship of serum protein bound iodine levels to rates of gain in beef cattle. J. Anim. Sci. 12: 3–9.CrossRefGoogle Scholar
Kunkel, H. O., Green, G. G., Riggs, J. K., Smith, R. L. and Myrtis, G. 1957. Relationship between serum protein bound iodine and other blood constituents to rates of gain in beef cattle. J. Anim. Sci. 16: 1030 (Abstr.).Google Scholar
Lindsay, R. H. and Cohen, P. P. 1965. Nucleic acid synthesis in normal and goitrous rat thyroid. Endocrinology 76: 737–744.CrossRefGoogle ScholarPubMed
Matsushima, J. K., Mukhtar, A. S., Clanton, D. C. and Payne, L. C. 1960. Thyroxine and testosterone implants for fattening lambs. J. Anim. Sci. 19: 1274.Google Scholar
Muhrer, M. E. and Hogan, A. G. 1945. Effect of thiouracil on growing swine. Proc. Soc. exp. Biol. Med. 60: 211–212.CrossRefGoogle ScholarPubMed
Peo, E. R. and Hudman, D. B. 1960. Supplementation of pig starters with thyroprotein. J. Anim. Sci. 19: 477–483.CrossRefGoogle Scholar
Perry, T. W., Beeson, W. M. and Andrews, F. N. 1950. The effect of thyroprotein on the growth and carcass composition of swine. J. Anim. Sci. 9: 48–53.CrossRefGoogle Scholar
Perry, T. W., Beeson, W. M. and Andrews, F. N. 1951. The effect of thyroprotein on the growth and thyrotrophic hormone content of the anterior pituitary of swine. J. Anim. Sci. 10: 129–137.CrossRefGoogle Scholar
Reineke, E. P. and McMillen, W. N. 1946. The effect of synthetic thyroprotein on lactation and growth in swine. J. Anim. Sci. 5: 420–421.Google Scholar
Robertson, H. A. and Falconer, I. R. 1961. The estimation of thyroid function and the evaluation of certain parameters. J. Endocr, 21: 411–420.CrossRefGoogle ScholarPubMed
Schmidt, G. and Thannhauser, S. J. 1945. A method for the determination of desoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues. J. biol. Chem. 161: 83–89.CrossRefGoogle ScholarPubMed
Schultze, A. B., Hathaway, I. L. and Loeffel, W. J. 1950. The influence of feeding thiouracil to dairy bull calves. J. Anim. Sci. 9: 571–577.CrossRefGoogle ScholarPubMed
Scott, J. F., Fraccastoro, A. P. and Taft, E. B. 1956. Histochemistry. 1. Determination of nucleic acids in microgram amounts of tissue. J. Histochem. Cytochem. 4: 1–10.CrossRefGoogle ScholarPubMed
Seibert, F. B. 1940. Removal of the impurities, nucleic acid and polysaccaride from tuberculin protein. J. biol. Chem. 133: 593–604.CrossRefGoogle Scholar
Stromlund, E. V., Reber, E. F., St Clair, L. E. and Kodras, R. 1960. Response of swine to surgical and radioiodine thyroidectomies. J. Anim. Sci. 19: 1337–1338.Google Scholar
Terrill, S. W., Hamilton, T. S., Krider, J. L. and Carroll, W. E. 1950. Carcass composition and nitrogen balances of swine fed thiouracil. J. Anim. Sci. 9: 58–65.CrossRefGoogle Scholar
Van Der Noot, G. W., Reece, R. P. and Skelly, W. C. 1948. Effects of thyroprotein and of thiouracil alone and in sequence in the ration of swine. J. Anim. Sci. 7: 84–91.CrossRefGoogle Scholar
Whiteker, M. D., Brown, H., Barnhart, C. E., Kemp, J. D. and Varney, W. Y. 1959. Effects of methylandrostenediol, methyltestosterone and thyroprotein on growth and carcass characteristics of swine. J. Anim. Sci. 18: 1189–1195.CrossRefGoogle Scholar