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Stimulation of protein absorption in the newborn piglet's intestine through the use of polyvalent cations

Published online by Cambridge University Press:  02 September 2010

M. W. Smith  and
K. A. Burton
M. W. Smith
Affiliation:
ARC Institute of Animal Physiology, Babraham, Cambridge
K. A. Burton
Affiliation:
ARC Institute of Animal Physiology, Babraham, Cambridge
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Summary

The transport of protein across the small intestine of the newborn pig was measured in vitro. The transport of both bovine immune globulin and bovine plasma albumin showed a large variation between piglets. The polycations poly-ornithine, poly-arginine and poly-lysine stimulated both the transport of globulin and albumin. Protamine, histone and arginine were without effect on protein transport. Poly-ornithine became bound to albumin and to the piglet intestinal mucosa. The amount of poly-ornithine needed to stimulate albumin transport was of the same order as that needed to change the electrophoretic mobility of brush border membranes and some 30 times less than that needed to change the charge on the protein. It is concluded that polycations stimulate protein transport by a direct action on the brush border membrane of the pig intestinal mucosa.

Type
Research Article
Information
Animal Production , Volume 15 , Issue 2 , October 1972 , pp. 139 - 146
Copyright
Copyright © British Society of Animal Science 1972

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References

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