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Published online by Cambridge University Press: 02 September 2010
The relationship between litter size at birth and litter weight at weaning is curvilinear, with an intermediate litter size resulting in the heaviest litter weight at weaning. Relative to feral mice, the mean and variation for litter size at birth was larger for domesticated mice which had been selected for fertility and crossbred. Consequently, some of the litters from the crossbred domesticated mice were larger than the litter size at birth which optimized litter weight at weaning, primarily due to increased pre-weaning mortality. If litter weight at weaning is to be optimized by indirect selection for litter size at birth, the variation around an intermediate optimum litter size at birth could be most effectively reduced by negative assortative mating.