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Immunological traits have the potential to improve selection of pigs for resistance to clinical and subclinical disease

Published online by Cambridge University Press:  09 March 2007

M. Henryon ,
P. M. H. Heegaard ,
J. Nielsen ,
P. Berg  and
H. R. Juul-Madsen
M. Henryon*
Affiliation:
Danish Institute of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, PO Box 50, 8830 Tjele, Denmark
P. M. H. Heegaard
Affiliation:
Danish Institute for Food and Veterinary Research, Department of Immunology and Biochemistry, Bülowsvej 27, 1790 Copenhagen V, Denmark
J. Nielsen
Affiliation:
Danish Institute for Food and Veterinary Research, Department of Virology, Lindholm, 4771 Kalvehave, Denmark
P. Berg
Affiliation:
Danish Institute of Agricultural Sciences, Department of Genetics and Biotechnology, Research Centre Foulum, PO Box 50, 8830 Tjele, Denmark
H. R. Juul-Madsen
Affiliation:
Danish Institute of Agricultural Sciences, Department of Animal Health, Welfare and Nutrition, Research Centre Foulum, PO Box 50, 8830 Tjele, Denmark
*
†Email: [email protected]
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Abstract

It was reasoned that, if we used a large sample of pigs, we could demonstrate that total and differential numbers of leukocytes, expression levels of swine leukocyte antigens (SLA) I and II, and serum concentrations of IgG and haptoglobin show additive genetic variation and are, therefore, potentially useful as criteria to improve selection of pigs for resistance to clinical and subclinical disease. We tested this premise by assessing 4204 male pigs from the Duroc, Landrace, and Yorkshire breeds for total and differential numbers of leukocytes and serum concentrations of IgG and haptoglobin; 1217 of the Duroc and Landrace pigs were also assessed for expression levels of SLA I and II. We estimated the amount of additive genetic variation by fitting linear animal models to the total and differential numbers of leukocytes and serum concentrations of IgG and haptoglobin. We fitted linear sire models to the expression levels of SLA I and II. We detected additive genetic variation for each group of traits. Total and differential numbers of leukocytes were moderately heritable (h2=0·22 to 0·30), expression levels of SLA I and II were moderate-to-highly heritable (h2=0·46 to 1·23), while serum concentrations of IgG and haptoglobin were lowly heritable (h2=0·14 to 0·16). The additive genetic variation shown for the immunological traits is encouraging for pig breeders. It indicates that these traits are potentially useful as criteria to improve selection of pigs for resistance to clinical and subclinical disease.

Keywords

disease resistancegenetic variationheritabilityimmunological factorspigsselection
Type
Research Article
Information
Animal Science , Volume 82 , Issue 5 , October 2006 , pp. 597 - 606
Copyright
Copyright © British Society of Animal Science 2006

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References

Edfors-Lilja, I., Wattrang, E., Magnusson, U. and Fossum, C. 1994. Genetic variation in parameters reflecting immune competence of swine. Veterinary Immunology and Immunopathology 40: 1–16.CrossRefGoogle ScholarPubMed
Enemark, H. L., Bille-Hansen, V., Lind, P., Heegaard, P. M.H., Vigre, H., Agrens, P. and Thamsborg, S. M. 2003. Pathogenicity of Cryptosporidium parvum - evaluation of an animal infection model. Veterinary Parasitology 113: 35–57.CrossRefGoogle ScholarPubMed
Geyer, C. J. 1992. Practical Markov chain Monte Carlo. Statistical Science 7: 473–511.Google Scholar
Hammerberg, C. and Schurig, G. G. 1986. Characterization of monoclonal antibodies directed against swine leukocytes. Veterinary Immunology and Immunopathology 11: 107–121.CrossRefGoogle ScholarPubMed
Henryon, M., Berg, P., Jensen, J. and Andersen, S. 2001. Genetic variation for resistance to clinical and subclinical diseases exists in growing pigs. Animal Science 73: 375–387.CrossRefGoogle Scholar
Henryon, M., Sørensen, P., Heegaard, P. M.H., Nielsen, J., Berg, P. and Juul-Madsen, H. R. 2006. Limited evidence that baseline levels of immunological traits provide useful selection criteria for resistance to clinical and subclinical disease in pigs. Proceedings of the eighth world congress on genetics applied to livestock production In press.CrossRefGoogle Scholar
Janeway, C. A. Jr., Travers, P., Walport, M. and Shlomchik, M.J. 2001. Immunobiology: the immune system in health and disease, fifth edition. Garland Publishing, New York.Google Scholar
Jensen, J., Mantysaari, E., Madsen, P. and Thompson, R. 1997. Residual maximum likelihood estimation of (co)variance components in multivariate mixed linear models using average information. Journal of the Indian Society of Agricultural Statistics 49: 215–236.Google Scholar
Jensen, P. T. and Christensen, K. 1981. Genetic studies on the in vitro PHA transformation of porcine lymphocytes. Veterinary Immunology and Immunopathology 2: 133–143.CrossRefGoogle Scholar
Jørgensen, B. 1992. Group-level effects of breed and sire on diseases, and influence of diseases on performance of pigs in Danish test stations. Preventive Veterinary Medicine 14: 281–292.CrossRefGoogle Scholar
Juul-Madsen, H. R., Dalgaard, T. S. and Afanassieff, M. 2000. Molecular characterization of major and minor MHC class I and II genes in B21-like haplotypes in chickens. Animal Genetics 31: 252–261.CrossRefGoogle ScholarPubMed
Kaufman, J., Volk, H. and Wallny, H. J. 1995. A ‘minimal essential Mhc’ and an ‘unrecognized Mhc’: two extremes in selection for polymorphism. Immunological Reviews 143: 63–88.CrossRefGoogle Scholar
Kaufmann, J. and Salomonsen, J. 1997. The ‘minimal essential MHC’ revisited: both peptide-binding and cell surface expression level of MHC molecules are polymorphisms selected by pathogens in chickens. Hereditas 127: 67–73.CrossRefGoogle Scholar
Korsgaard, I. R., Lund, M. S., Sørensen, D., Gianola, D., Madsen, P. and Jensen, J. 2003. Multivariate Bayesian analysis of Gaussian, right censored Gaussian, ordered categorical and binary traits using Gibbs sampling. Genetics, Selection, Evolution 35: 159–183.CrossRefGoogle ScholarPubMed
Lingaas, F. and Rønningen, K. 1991. Epidemiological and genetic studies in Norwegian pig herds. V. Estimates of heritability and phenotypic correlations of the most common diseases in Norwegian pig production. Acta Veterinaria Scandinavica 32: 115–122.CrossRefGoogle Scholar
Lundeheim, N. 1979. Genetic analysis of respiratory diseases in pigs. Acta Agriculturæ Scandinavica A 29: 209–215.CrossRefGoogle Scholar
Lundeheim, N. 1988. Health disorders and growth performance at a Swedish pig progeny testing station. Acta Agriculturæ Scandinavica A 38: 77–88.CrossRefGoogle Scholar
Madsen, P. and Jensen, J. 2005. A user's guide to DMU (version 6, release 4·5). Danish Institute of Agricultural Sciences, Department of Genetics and Biotechnology, Research Center Foulum, Denmark.Google Scholar
Mallard, B. A., Wilkie, B. N., Kennedy, B. W., Gibson, J. and Quinton, M. 1998. Immune responsiveness in swine: Eight generations of selection for high and low immune response in Yorkshire pigs. In Proceedings of the sixth world congress on genetics applied to livestock production, vol. 27, pp. 257–264Google Scholar
Mallard, B. A., Wilkie, B. N., Kennedy, B. W. and Quinton, M. 1992. Use of estimated breeding values in a selection index to breed Yorkshire pigs for high and low immune and innate resistance factors. Animal Biotechnology 3: 257–280.CrossRefGoogle Scholar
Myers, R. H. 1989. Classical and modern regression with applications, second edition. Duxbury Press, Belmont.Google Scholar
Rothschild, M. F., Chen, H. L., Christian, L. L., Lie, W. R., Venier, L., Cooper, M., Briggs, C. and Warner, C. M. 1984a. Breed and swine lymphocyte antigen haplotype differences in agglutination titres following vaccination with B. bronchiseptica. Journal of Animal Science 59: 643–649.CrossRefGoogle ScholarPubMed
Rothschild, M. F., Hill, H. T., Christian, L. L. and Warner, C. M. 1984b. Genetic differences in serum neutralization titres of pigs after vaccination with pseudorabies modified live-virus vaccine. American Journal of Veterinary Research 45: 1216–1218.Google ScholarPubMed
Smith, C., King, J. W.B. and Gilbert, N. 1962b. Genetic parameters of British large white bacon pigs. Animal Production 4: 128–143.Google Scholar
Straw, B. E., Burgi, E. J., Hilley, H. D. and Leman, A. D. 1983. Pneumonia and atrophic rhinitis in pigs from a test station. Journal of the American Veterinary Medical Association 182: 607–611.Google ScholarPubMed
Straw, B. E., Leman, A. D. and Robinson, R. A. 1984. Pneumonia and atrophic rhinitis in pigs from a test station - a follow-up study. Journal of the American Veterinary Medical Association 185: 1544–1546.Google ScholarPubMed
Straw, B. E. and Rothschild, M. F. 1992. Genetic influences on liability to acquired disease. In Diseases of swine, seventh edition (ed. Leman, A. D., Straw, B. E., Mengeling, W. L., Allaire, S. D. and Taylor, D.J.), pp. 709–717. Iowa State University Press, Ames.Google Scholar
Wilkie, B. and Mallard, B. 1999. Selection for high immune response: an alternative approach to animal health maintenance? Veterinary Immunology and Immunopathology 72: 231–235.CrossRefGoogle ScholarPubMed
Wilkie, B. and Mallard, B. 2000. Genetic aspects of health and disease resistance in pigs. In Breeding for disease resistance in farm animals, second edition (ed. Axford, F. E., Bishop, S. C., Nicholas, F. W. and Owen, J. B.), pp. 379–396. CAB International, Wallingford.Google Scholar