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Holo-analysis of the efficacy of Bio-Mos® in pig nutrition

Published online by Cambridge University Press:  09 March 2007

G. D. Rosen
G. D. Rosen*
Affiliation:
Holo-Analysis Services Ltd, 66 Bathgate Road, London, SW19 5PH, UK
*
†E-mail: [email protected]
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Abstract

This exploratory holo-analysis of the efficacy of Bio-Mos®, (BM), an outer cell wall derivative of a strain of Saccharomyces cerevisiae, is part of an empirical modelling research programme comparing the efficacies of potential replacements for veterinary prescription-free pronutrient antibiotics in pig production. The data resource was mined from 128 saccharide publications of which 31/97 on BM (1997 to 2003) provided 69 negatively controlled start-to-finish tests from 10 countries (USA 71%) using 3778 pigs(30·5 per treatment). Respective food intake, live-weight gain and food conversion responses of 0·0075 kg/day (0·99%), 0·0145 kg/day (3·58%) and −0·0526 (3·07%) have coefficients of variation of 511, 163 and 229% and beneficial gain and conversion frequencies of 73 and 68%, 54% jointly. Holo-analytical multiple regression models of BM food intake, live-weight gain and food conversion effects using conventional and less stringent probabilities contain significant independent variables for negative control performances, dosage, discontinuous dosage, test duration, year of test, non-USA test, male, grower-finisher, slatted floor, processed food, antibacterial foods, animal protein food, main vegetable protein not soya bean, added oil/fat food and factorial data, which account for 11 to 68% of variations in response. The models quantify differences in research and praxis and indicate areas for future modelling research on BM dose-response relations, effects of ration ingredient and nutrient contents, other saccharide efficacy comparisons, including lactose, and BM comparisons and interactions with other proposed antibiotic replacements.

Keywords

Bio-Mos®holo-analysispigsnutrition
Type
Research Article
Information
Animal Science , Volume 82 , Issue 5 , October 2006 , pp. 683 - 689
Copyright
Copyright © British Society of Animal Science 2006

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References

Bae, K. H., Ko, T. G., Kim, J. H., Cho, W. T., Han, Y. K. and Han, K. 1999. Use of metabolically active substances to substitute for antibiotics in finishing pigs. Korean Journal of Animal Science 41: 23–30.Google Scholar
Bolduan, G., Schuldt, A. and Hackl, W. 1997. Diet feeding in weaner piglets. Archiv für Tierzucht 40: 95–100.Google Scholar
Brendemuhl, J. H. and Harvey, M. R. 1999. Evaluation of Bio-Mos (mannanoligosaccharide) in diets for pigs. 1. Growth performance response during nursery and growing-finishing phases. Alltech Report Bio-Mos.63.eng.RT pp. 3.Google Scholar
Close, W. H. and Turnley, K. 2004. Creating technical and educational forums that help pig producers meet performance and economic goals: the Premier Pig Program™. In Biotechnology in the feed and food industries, Proceedings of Alltech's 20th annual symposium (ed. Lyons, T. P., Jacques, K. A.), pp. 113–119. Nottingham University Press, Nottingham.Google Scholar
Davis, E. and Maxwell, C. 2002. Summary of nursery and growing-finishing Bio-Mos® trials conducted at the University of Arkansas. Alltech Report Bio-Mos.212.eng.RT, p. 2.Google Scholar
Davis, E., Maxwell, C., Brown, D. and Johnson, Z. 2000a. Efficacy of mannan oligosaccharide (Bio-Mos) addition with and without zinc oxide on performance and immunocompetence on weanling pigs. Agricultural Experiment Station Research Series 478: 118–123.Google Scholar
Davis, E., Maxwell, C., De Rodas, B. and Brown, D. 2000b. Effect of mannan oligosaccharide (Bio-Mos) addition with and without zinc oxide on performance and immunocompetence of weanling pigs. Arkansas Agricultural Experiment Station Research Series 478: 112–117.Google Scholar
Davis, E., Maxwell, C., Kegley, B., De Rodas, B., Friesen, K. and Hellwig, D. 1999. Efficacy of mannan oligosaccharide (Bio-Mos ®) addition at two levels of supplemental copper on performance and immunocompetence of early weaned pigs. Agricultural Experiment Station Research Series 410: 15–18.Google Scholar
Davis, M. E., Brown, D. C., Maxwell, C. V., Johnson, Z. B., Kegley, E. B. and Dvorak, R. A. 2004. Effect of phosphorylated mannans and pharmacological additions of zinc oxide on growth and immunocompetence of weanling pigs. Journal of Animal Science 82: 581–587.CrossRefGoogle ScholarPubMed
Davis, M. E., Maxwell, C. V., Brown, D. C., de Rodas, B. Z., Johnson, Z. B., Kegley, E. B., Hellwig, D. H. and Dvorak, R.A. 2002. Effect of dietary mannanoligosaccharides and (or) pharmacological additions of copper sulphate on growth performance and imunocompetence of weanling and growing/finishing pigs. Journal of Animal Science 80: 2887–2894.CrossRefGoogle Scholar
Davis, M. E., Maxwell, C. V., Erf, G. F., Brown, D. C. and Wistuba, T. J. (undated). Dietary supplementation with phosphorylated mannans improves growth response and modulates immune function of weanling pigs. Report, pp. 24.Google Scholar
Duenas, H. B. and Castro, A. L. 2002. Response to a Bio-Mos® step-down program in pigs post-weaning. Alltech Report Bio-Mos.216.eng.RT, p. 1.Google Scholar
Dvorak, R. 1998. Mannaoligosaccharide, fructooligosaccharide and carbadox for pigs days 0–21 post-weaning. Alltech Report 51·062, p. 3.Google Scholar
Forat, M. and Garcia, E. M. 2001. Weaned piglets fed with diets including Bio-Mos compared to Tylan-sulfa diets. Instituto Internacional de Investigacion Animal Report 1–01–C, p. 19.Google Scholar
Grela, E. 2003. Effectiveness of Bio-Mos in feeding pigs. Trial protocol, p. 4.Google Scholar
Harper, A. F. and Estienne, M. J. 2000. Efficacy of carbadox antibiotic and a mannan-oligosaccharide source as growth promoters for weanling pigs. Journal of Animal Science 78: (suppl.) 12.Google Scholar
Hernan, D. B. 2001. AASA trial with Bio-Mos, report, p. 2.Google Scholar
JMP 2000. JMP statistics and graphics guide, version 4. SAS Institute, Inc, Cary, NC.Google Scholar
Kim, J. D., Hyun, Y., Sohn, K. S., Kim, T. J., Woo, H. J. and Han, K. 2000a. Effects of mannanoligosaccharide and protein levels on growth performance and immune status in pigs weaned at 21 days of age. Journal of Animal Science and Technology (Korea) 42: 489–498.Google Scholar
Kim, J. D., Hyun, Y., Sohn, K. S., Woo, H. J., Kim, T. J. and Han, K. 2000b. Effects of immunostimulators on growth performance and immune response in pigs weaned at 21 days of age. Journal of Animal and Feed Sciences 200: 333–346.CrossRefGoogle Scholar
Ko, T. G., Kim, J. D., Bae, S. H., Han, Y. K. and Han, K. 2000a. Study for the development of antibiotics-free diet for weanling pigs. Korean Journal of Animal Nutrition 42: 37–44.Google Scholar
Ko, T. G., Kim, J. D., Han, Y. K. and Han, K. 2000b. Study for the development of antibiotics-free diet for growing pigs. Korean Journal of Animal Science 42: 45–54.Google Scholar
Kumprecht, I. and Zobac, P. 1998. Study of the effect of a combined preparation containing Enterococcus faecium M-74 and mannan-oligosaccharides in diets for weaning piglets. Czech Journal of Animal Science 43: 477–481.Google Scholar
Lannon, P. F. 2002. The effect of mannanoligosaccharide on growth performance and fecal microbial populations in pigs 1–60 days of age. Abstract of MSc thesis, University of Florida.Google Scholar
LeMieux, F. M., Bidner, T. and Southern, L. L. 2000. Effect of 0·2 and 0·3% Bio-Mos with and without 3,000 ppm zinc on growth performance of weanling pigs. Alltech Report Bio-Mos.56.eng.RT, p. 2.Google Scholar
LeMieux, F. M., Southern, L. L. and Bidner, T. D. 2003. Effect of mannan oligosaccharides on the growth performance of weanling pigs. Journal of Animal Science 81: 2482–2487.CrossRefGoogle ScholarPubMed
Maxwell, C., Singh, S. and Johnson, Z. 2000. Efficacy of Bio-Mos and Lacto-Mos PlusR in improving gain and efficiency in growing-finishing pigs. First draft research report (10–19–00) p. 4. University of Arkansas.Google Scholar
Popovic, O. and Sinovec, Z 1999. Effect of different growth promoters on piglet performance. Alltech Report Bio-Mos.212.eng.RT, p. 2.Google Scholar
Popovic, O., Sinovec, Z., Joganovic, N. and Sekler, M. 2000. Use of antibiotics and prebiotics in pig diet for stimulative purposes. Veterinarski Glasnik 54: 125–133.Google Scholar
Pulliam, J., Clift, R., Chattin, S. and Mathew, A. G. 2003. Effects of feeding antibiotics versus mannanoligosaccharides on the growth performance of weanling pigs. Journal of Animal Science 81: (suppl.) 202–203.Google Scholar
Rosen, G. D. 2006a. Setting and meeting standards for the efficient replacement of pronutrient antibiotics in poultry and pig nutrition. In Antimicrobial growth promoters. Where do we go from here? (ed. Barug, D., De Jong, J., Kies, A. K., Verstegen, M. W.A.), pp. 381–397. Wageningen Academic Publishers, The Netherlands.CrossRefGoogle Scholar
Rosen, G. D. 2006b. Holo-analysis of the effects of genetic, chronological and dietary variables on the efficacy of a pronutrient mannanoligosaccharide in piglets. Proceedings of the 56th annual meeting of the European Association for Animal Production, 5 to 8 June, 2005, Uppsala. Wageningen Academic Publishers, Wageningen (abstr.) In press.Google Scholar
Rosen, G. D. 2006c. Holo-analysis of the effects of genetic, managemental, chronological and dietary variables on the efficacy of a pronutrient mannanoligosaccharide in pigs. Journal of Animal Science 83: (suppl) 83 (abstr.).Google Scholar
Rosen, G. D. 2006d. Holo-analysis of the efficacy of Bio-Mos® in broiler nutrition. British Poultry Science In press.Google Scholar
Rosen, G. D. 2006e. Holo-analysis of the efficacy of Bio-Mos® in turkey nutrition. British Poultry Science In press.Google Scholar
Stockland, W. L. 1999. Practical solutions to maximise production: the commercial application of oligosaccharides in starter pigs diets. In Proceedings of the first Turtle Lake pig science conference. pp. 71–80.Google Scholar
Vander Beke, N. 1997. The use of mannanoligosaccharides (Bio-Mos) and lactobacilli (Lacto-Sacc) in pig feeds. Thesis, University of Ghent.Google Scholar
Zhou, H., Zhang, S. and Hi, J. 2002. Effects of mannan-oligosaccharide on intestinal flora, antibody level and performance of weaning piglets. Journal of Hunan Agricultural University (Natural Sciences) 28: 135–138.Google Scholar