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Effects of Zeranol® implants and dietary supplement on growth rate, endocrine status and blood metabolite levels of growing lambs at pasture

Published online by Cambridge University Press:  02 September 2010

S. M. Rhind ,
D. Zygoyiannis ,
J. M. Doney ,
I. D. Leslie  and
I. C. Hart
S. M. Rhind
Affiliation:
Hill Farming Research Organisation, Bush Estate, Penicuik, Midlothian EH26 0PY
D. Zygoyiannis
Affiliation:
Hill Farming Research Organisation, Bush Estate, Penicuik, Midlothian EH26 0PY
J. M. Doney
Affiliation:
Hill Farming Research Organisation, Bush Estate, Penicuik, Midlothian EH26 0PY
I. D. Leslie
Affiliation:
Hill Farming Research Organisation, Bush Estate, Penicuik, Midlothian EH26 0PY
I. C. Hart
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
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Abstract

In a 2 × 2 factorial experiment, the effect of implants of the growth promoter Zeranol, with and without supplementary food, on the growth rate, blood metabolite and hormone profiles of lambs finished at pasture was examined. For lambs fed no supplement, Zeranol implants increased growth rates from 166 to 185 g/day (s.e. of difference = 11·4) whereas for animals fed supplement the response to Zeranol was much greater, the growth rates being 167 and 234 g/day (s.e. of difference = 12·8). Supplement given to lambs not treated with Zeranol replaced a proportion of the herbage intake while, in lambs given supplement and treated with Zeranol, herbage intake was greatly increased (P < 0·001). Plasma glucose and urea concentrations were not affected by treatment but non-esterified fatty acids (NEFA) were depressed and albumin levels increased by Zeranol implants, while supplementary food caused reductions in plasma NEFA and urea concentrations. It is suggested that Zeranol treatment and supplementary food acted synergistically through changes in insulin and growth hormone concentrations to induce a much larger increase in growth rate in the treated animals given supplementary food than in those given either Zeranol or supplement alone. The response to Zeranol may also have been altered by differences in thyroid hormone status associated with supplementary food.

Type
Research Article
Information
Animal Production , Volume 39 , Issue 2 , October 1984 , pp. 269 - 276
Copyright
Copyright © British Society of Animal Science 1984

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References

REFERENCES

Alexander, R. H. 1969. The establishment of a laboratory procedure for the in vitro determination of digestibility. Res. Bull. W. Scotl. agric. Coll., No. 42.Google Scholar
Bassett, J. M. 1978. Endocrine factors in the control of nutrient utilization: ruminants. Proc. Nutr. Soc. 37: 273–280.CrossRefGoogle ScholarPubMed
Borger, M. L., Wilson, L. L., Sink, J. D., Ziegler, J. H. and Davis, S. L. 1973. Zeranol and dietary protein level effects on live performance, carcass merit, certain endocrine factors and blood metabolite levels of steers. J. Anim. Sci. 36: 706–711.CrossRefGoogle ScholarPubMed
Collier, M. 1970. An automated procedure for the simultaneous estimation of total protein and albumin in serum. J. med. Lab. Technol. 27: 86–93.Google ScholarPubMed
Davis, S. L., Ohlson, D. L., Klindt, J. and Anfinson, M. S. 1978. Episodic patterns of prolactin and thyrotropin secretion in rams and wethers: influence of testosterone and diethylstilbestrol. J. Anim. Sci. 46: 1724–1729.CrossRefGoogle Scholar
Doney, J. M., Smith, A. D. M., Sim, D. A. and Zygoyiannis, D. 1984. Milk and herbage intake of suckled and artificially reared lambs at pasture as influenced by lactation pattern. Anim. Prod. 38: 191–199.Google Scholar
Easdon, M. 1981. The effect of undernutrition on some hormones and metabolites in the blood of intact and ovariectomised beef cows. Ph.D. Thesis, Univ. Aberdeen.Google Scholar
Galbraith, H. 1979. Effect of Zeranol implantation on the growth and blood metabolites and hormones of beef heifers. Anim. Prod. 28: 417–418 (Abstr.).Google Scholar
Galbraith, H. 1980. The effect of trenbolone acetate on growth, blood hormones and metabolites, and nitrogen balance of beef heifers. Anim. Prod. 30: 389–394.Google Scholar
Galbraith, H. 1982. Growth, hormonal and metabolic response of post-pubertal entire male cattle to trenbolone acetate and hexoestrol. Anim. Prod. 35: 269–276.Google Scholar
Gutteridge, J. M. C. and Wright, E. B. 1968. A simple automated guaiacum glucose-oxidase method. J. med. Lab. Technol. 25: 385–386.Google ScholarPubMed
Hart, I. C, Flux, D. S., Andrews, P. and McNeilly, A. S. 1975. Radio-immunoassay for ovine and caprine growth hormone: its application to the measurement of basal circulating levels of growth hormone in the goat. Hormone Metab. Res. 7: 35–40.CrossRefGoogle Scholar
Heitzman, R. J. 1979. The efficacy and mechanism of action of anabolic agents as growth promoters in farm animals. J. Steroid Biochem. 11: 927–930.CrossRefGoogle ScholarPubMed
Heitzman, R. J. 1981. Mode of action of anabolic agents. In Hormones and Metabolism in Ruminants (ed. Forbes, J. M. and Lomax., M. A.), pp. 129–139. Agricultural Research Council, London.Google Scholar
McNeilly, A. S. and Andrews, P. 1974. Purification and characterisation of caprine prolactin. J. Endocr. 60: 359–367.CrossRefGoogle ScholarPubMed
Marsh, W. H., Fingerhut, B. and Miller, H. 1965. Automated and manual direct methods for the determination of blood urea. Clin. Chem. 11: 624–627.CrossRefGoogle ScholarPubMed
Maund, Barbara A. 1976. The effect of implanting Zeranol on the growth rate of fattening lambs. Anim. Prod. 22: 149 (Abstr.).Google Scholar
Ministry Of Agriculture, Fisheries and Food, Department Of Agriculture and Fisheries For Scotland and Department Of Agriculture For Northern Ireland. 1975. Energy allowances and feeding systems for ruminants. Tech. Bull. 33. Her Majesty's Stationery Office, London.Google Scholar
Olsen, R. F., Wangsness, P. J., Martin, R. J. and Gahagan, J. H. 1977. Effects of Zeranol on blood metabolites and hormones in wether lambs. J. Anim. Sci. 45: 1392–1396.CrossRefGoogle ScholarPubMed
Osmond, T. J. 1980. Studies of hormones in relation to genetic merit of dairy cattle. Ph.D. Thesis, Univ. Edinburgh.Google Scholar
Patterson, D. S. P. 1963. Some observations on the estimation of non-esterified fatty acid concentrations in cow and sheep plasma. Res. vet. Sci. 4: 230–237.CrossRefGoogle Scholar
Quirke, J. F. and Sheehan, W. 1981. Effects of anabolic steroids on the performance of hill and lowland lambs. Ir. J. agric. Res. 20: 125–135.Google Scholar
Seth, J., Toft, A. D. and Irvine, W. J. 1976. Simple solid-phase radio-immunoassays for total tri-iodothyronine and thyroxine in serum, and their clinical evaluation. Clinica chim. Ada 68: 291–301.CrossRefGoogle Scholar
Sharp, G. D. and Dyer, I. A. 1971. Effect of zearalanol on the performance and carcass composition of growing-finishing ruminants. J. Anim. Sci. 33: 865–871.CrossRefGoogle Scholar
Trenkle, A. and Topel, D. G. 1978. Relationships of some endocrine measurements to growth and carcass composition of cattle. J. Anim. Sci. 46: 1604–1609.CrossRefGoogle Scholar
Wangsness, P. J., Olsen, R. F. and Martin, R. J. 1981. Effects of breed and Zeranol implantation on serum insulin, somatomedin-like activity and fibroblast proliferative activity. J. Anim. Sci. 52: 57–62.CrossRefGoogle ScholarPubMed