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The effects of long-term administration of bovine growth hormone on the lactational performance of identical-twin dairy cows

Published online by Cambridge University Press:  02 September 2010

C. J. Peel ,
L. D. Sandles ,
Kaylene J. Quelch  and
A. C. Herington
C. J. Peel
Affiliation:
Ellinbank Dairy Research Institute, Warragul 3820, Australia
L. D. Sandles
Affiliation:
Ellinbank Dairy Research Institute, Warragul 3820, Australia
Kaylene J. Quelch
Affiliation:
St Vincents School of Medical Research, Fitzroy, Victoria 3065, Australia
A. C. Herington
Affiliation:
Medical Research Centre, Prince Henry's Hospital, Melbourne 3004, Australia
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Abstract

The effect of chronic administration of bovine growth hormone (GH) on milk production, food intake and live-weight change was evaluated in five sets of monozygotic twin cows on pasture. Purified bovine pituitary GH (specific activity, 0·78 IU/mg) was administered by daily subcutaneous injections (39 IU/day) for a period of 22 weeks (weeks 5 to 26 of lactation). GH treatment resulted in significantly higher yields of milk (23·3 kg/day), fat (0·97 kg/day), protein (0·74 kg/day) and lactose (115 kg/day) compared with the control group (19·8 kg/day, 0·79 kg/day, 0·63 kg/day, 0·99 kg/day). Milk composition did not differ between treatment groups. There was no difference in the intake of cut grass in week 8 but the voluntary intake of the GH group had increased by week 22 (controls, 15·4 kg dry matter (DM) per day and GH group, 17·5 kg DM per day). There were no differences in the rate of live-weight change for the two groups. Serum somatomedin concentrations were significantly elevated in the GH group on weeks 20 to 22 of treatment (0·043 v. 0·135 U/ml). This experiment indicates that cows chronically treated with GH were able to adjust their food intake upwards to sustain a substantial increase in milk production on a diet composed solely of grass.

Type
Research Article
Information
Animal Production , Volume 41 , Issue 2 , October 1985 , pp. 135 - 142
Copyright
Copyright © British Society of Animal Science 1985

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References

REFERENCES

Bauman, D. E. and Currie, W. B. 1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J. Dairy Sci. 63: 1514–1529.CrossRefGoogle ScholarPubMed
Bauman, D. E., Degeeter, M. J., Peel, C. J., Lanza, G. M., Gorewit, R. C. and Hammond, R. W. 1982. Effect of recombinantly derived bovine growth hormone (bGH) on lactational performance of high yielding dairy cows. J. Dairy Sci. 65: Suppl. l, p. 121 (Abstr.).Google Scholar
Bauman, D. E., Eppard, P. J., Degeeter, M. J. and Lanza, G. M. 1985. Responses of high producing dairy cows to long-term treatment with pituitary- and recombinant-growth hormone. J. Dairy Sci. 68: 1352–1362.CrossRefGoogle Scholar
Bremner, W. J., Findlay, J. K., Lee, V. W. K., De KRETSER, D. M. and Cumming, I. A. 1980. Feedback effects of the tests on pituitary responsiveness to LHRH infusions in the ram. Endocrinology 106: 329–336.CrossRefGoogle Scholar
Brumby, P. J. and Hancock, J. 1955. The galactopoietic role of growth hormone in dairy cattle. N. Z. Jl Sci. Technol. 36:417–436.Google Scholar
Davis, S. R., Barry, T. N., and Hughson, G. A. 1981. Protein synthesis in tissues of growing lambs. Br. J. Nutr. 46: 409–419.Google Scholar
Earle, D. F. 1976. A guide to scoring cow condition. J. Agric. Viet. Dep. Agric. 74: 228–231.Google Scholar
Franklin, R. C., Rennie, G. C., Burger, H. G. and Cameron, D. P. 1976. A bioassay for NSILA-S in individual serum samples and its relationship to somatotropin. J. din. Endocr. Metdb. 43: 1164–1169.CrossRefGoogle ScholarPubMed
Gertler, A., Ashkenazi, A. and Madar, Z. 1984. Binding sites of human growth hormone and ovine and bovine prolactins in the mammary gland and the liver of lactating dairy cows. Mol. Cell. Endocr. 34: 51–57.CrossRefGoogle Scholar
Gertler, A., Cohen, N. and Maoz, A. 1983. Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolcactin-like activity in organ cultures from bovine lactating mammary gland. Mol. Cell. Endocr. 33: 169–182.CrossRefGoogle ScholarPubMed
Harrison, F. A., Laby, R. H. and Mangan, J. L. 1982. The release and movement of chromic oxide from a capsule in the rumen of sheep. Proc. Nutr. Soc. 41: 55A (Abstr.).Google Scholar
Hart, I. C. 1983. Endocrine control of nutrient partitioning in lactating ruminants. Proc. Nutr. Soc. 42: 181–194.CrossRefGoogle ScholarPubMed
Hart, I. C., Bines, J. A. and Morant, S. V. 1980. The secretion and metabolic clearance rates of growth hormone, insulin, and prolactin in high- and low- yielding cattle at four stages of lactation. Life Sci. 27: 1839–1847.CrossRefGoogle ScholarPubMed
Herington, A. C., Jacobs, L. S. and Daughaday, W. H. 1974. Radioreceptor and radioimmunoassay quantitation of human growth hormone in acromegalic serum: overestimation by immunoassay and systematic differences between antisera. J. din. Endocr. Metab. 39: 256–261.Google Scholar
Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of Bacteriophage T4. Nature, Land. 227: 680–685.CrossRefGoogle ScholarPubMed
Lee, V. W. K., Cumming, I. A., De KRETSER, D. M., Findlay, J. K., Hudson, B. and Keogh, E. J. 1976. Regulation of gonadotrophin secretion in rams from birth to sexual maturity. I. Plasma LH, FSH and testosterone levels. J. Reprod. Fert. 46: 1–6.Google Scholar
McDowell, G. H., Hart, I. C., Bines, J. A. and Lindsay, D. B. 1983. Effects of exogenous growth hormone in lactating cows. Proc. Nutr. Soc. Aust. 8: 165 (Abstr.).Google Scholar
MacHlin, L. J. 1973. Effect of growth hormone on milk production and feed utilization in dairy cows. J. Dairy Sci. 56: 575–580.CrossRefGoogle ScholarPubMed
Moseley, W. M., Krabill, L. F. and Olsen, R. F. 1982. Effect of bovine growth hormone administered in various patterns on nitrogen metabolism in the Holstein steer. J. Anim. Sci. 55: 1062–1070.CrossRefGoogle ScholarPubMed
Peel, C. J., Bauman, D. E., Gorewit, R. C. and Sniffen, C. J. 1981. Effect of exogenous growth hormone on lactational performance in high yielding dairy cows. J. Nutr. 111: 1662–1671.CrossRefGoogle ScholarPubMed
Peel, C. J., Fronk, T. J., Bauman, D. E. and Gorewit, R. C. 1983. Effects of exogenous growth hormone in early and late lactation on lactational performance of dairy cows. J. Dairy Sci. 66: 776–782.Google Scholar
Peel, C. J., Steinhour, W. D., Bauman, D. E., Tyrrell, H. F., Brown, A. C. G., Reynolds, P. J. and Haaland, G. L. 1982. Administration of bovine growth hormone to high yielding Holstein cows: II. Influence on irreversible loss and oxidation rate of free fatty acids and glucose. J. Dairy Sci. 65: Suppl. I, p. 120–121 (Abstr.).Google Scholar
Reichert, L. E. Jr, 1975. Purification of anterior pituitary hormones (ovine, bovine, rat and rabbit). In Methods of Enzymology. Vol. 37. Hormone Action. Part B. Peptide Hormones (ed. O'Malley, B. W. and Hardman, J. G.), pp. 360–380. Academic Press, New York.Google Scholar
Stelmasiak, T., Johnson, N. E., Hennessy, D. P. and Outch, R. H. 1985. Individual differences in adrenal responses to ACTH stimulation in the pig. Aust. J. biol. Sci. 38: In press.Google Scholar
Stephenson, R. G. A., Ngongoni, N. T., Robinson, J. J. and Atkinson, T. 1983. The effect of hormone status on the rate of outflow of a chromium-mordanted protein concentrate from the rumen of ewes. Proc. Nutr. Soc. 42: 37A (Abstr.).Google Scholar
Tyrrell, H. F., Brown, A. C. G., Reynolds, P. J., Haaland, G. L., Pekl, C. J., Bauman, D. E. and Steinhour, W. D. 1982. Administration of bovine growth hormone to high yielding Hoistein cows. 1. Influence on in vivo energy metabolism. J. Dairy Sci. 65: Suppl. 1, p. 120 (Abstr.).Google Scholar