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The effects of exogenous bovine growth hormone and bromocriptine on growth, body development, fleece weight and plasma concentrations of growth hormone, insulin and prolactin in female lambs

Published online by Cambridge University Press:  02 September 2010

I. D. Johnsson ,
I. C. Hart  and
B. W. Butler-Hogg
I. D. Johnsson
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
I. C. Hart
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading RG2 9AT
B. W. Butler-Hogg
Affiliation:
AFRC Food Research Institute, Carcass and Abattoir Division, Langford, Bristol BS18 7DY
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Abstract

In crossbred female lambs given a concentrate diet ad libitum between 8 and 20 weeks of age, daily subcutaneous injections of 0·1 mg bovine pituitary growth hormone (GH) per kg live weight increased daily live-weight gain (347 v. 284 g/day; P < 0·01; no. = 8), food conversion efficiency (3·94 v. 4·49 kg dry matter per kg gain; P < 0·01) and greasy fleece weight (1·49 v. 0·99 kg; P < 0·001). The increase (4·8 kg) in final live weight was due primarily to an increase in the non-carcass components of the body (3·5 kg), with little effect on carcass weight (1·3 kg). However, bovine GH treatment markedly increased the weights of lean tissue (11·4 v. 9·2 kg; P < 0·001) and bone (2·8 v. 2·4 kg; P < 0·001) and moderately reduced the weight of fat (7·0 v. 8·0 kg; P < 0·10) in the carcass. The bovine GH treatment raised plasma concentrations of immunoreactive GH within the physiological range for about 16 h each day and significantly increased mean plasma concentrations of insulin and prolactin. Daily injection of 1 mg bromocriptine had no effect on daily live-weight gain, food conversion efficiency or carcass composition. This treatment markedly reduced plasma concentrations of prolactin but also significantly reduced insulin concentrations. When given in combination with bovine GH, bromocriptine reduced the GH-induced stimulation of insulin concentration and tended to decrease the effects of GH on food conversion efficiency and growth. This interaction was significant only for the effects on greasy fleece and skin weights (P < 0·01).

Type
Research Article
Information
Animal Production , Volume 41 , Issue 2 , October 1985 , pp. 207 - 217
Copyright
Copyright © British Society of Animal Science 1985

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References

REFERENCES

Bassett, J. M. 1974. Diurnal patterns of plasma insulin, growth hormone, corticosteroid and metabolite concentrations in fed and fasted sheep. Aust. J. biol. Sci. 27: 167–181.CrossRefGoogle ScholarPubMed
Bauman, D. E., Eisemann, J. H. and Currie, W. B. 1982. Hormonal effects on partitioning of nutrients for tissue growth: role of growth hormone and prolactin. Fedn Proc. Fedn Am. Socs exp. Biol. 41: 2538–2544.Google Scholar
Bines, J. A., Hart, I. C. and Morant, S. V. 1980. Endocrine control of energy metabolism in the cow: the effect on milk yield and levels of some blood constituents of injecting growth hormone and growth hormone fragments. Br. J. Nutr. 43: 179–188.CrossRefGoogle ScholarPubMed
Braithwaite, G. D. 1975. The effect of growth hormone on calcium metabolism in the sheep. Br. J. Nutr. 33: 309–314.CrossRefGoogle ScholarPubMed
Brown, W. B., Driver, P. M., Jones, R. and Forbes, J. M. 1976. Growth, prolactin and growth hormone in lambs treated with CB154. J. Endocr. 69: 47P (Abstr.).Google ScholarPubMed
Brumby, P. J. 1959. The influence of growth hormone on growth in young cattle. N.Z. Jl agric. Res. 2: 683–689.CrossRefGoogle Scholar
Davis, S. L., Garrigus, U. S. and Hinds, F. C. 1970. Metabolic effects of growth hormone and diethylstilbestrol in lambs. II. Effects of daily ovine growth hormone injections on plasma metabolites and nitrogen-retention in fed lambs. J. Anim. Sci. 30: 236–240.CrossRefGoogle ScholarPubMed
Davis, S. L., Hossner, K. L. and Ohlson, D. L. 1984. Endocrine regulation of growth in ruminants. In Manipulation of Growth in Farm Animals (ed. Roche, J. F. and O'Callaghan, D.), pp, 151–178. Martinus Nijhoff, Boston, USA.CrossRefGoogle Scholar
Eisemann, J. H., Bauman, D. E., Hogue, D. E. and Travis, H. F. 1984a. Evaluation of a role for prolactin in growth and the photoperiod-induced growth response in sheep. J. Anim. Sci. 59: 86–94.CrossRefGoogle ScholarPubMed
Eisemann, J. H., Bauman, D. E., Hogue, D. E. and Travis, H. F. 1984b. Influence of photoperiod and prolactin on body composition and in vitro lipid metabolism in wether lambs. J. Anim. Sci. 59: 95–104.CrossRefGoogle ScholarPubMed
Ellis, S. 1961. Studies on the serial extraction of pituitary proteins. Endocrinology 69: 554–570.CrossRefGoogle ScholarPubMed
Ferguson, K. A. 1954. Prolonged stimulation of wool growth following injections of ox growth hormone. Nature, Lond. 174: 411.CrossRefGoogle ScholarPubMed
Galbraith, H. 1983. Response of cattle and sheep to hormonal anabolic compounds. Vet. Res. Commun. 7:27–34CrossRefGoogle ScholarPubMed
Galbraith, H. and Topps, J. H. 1981. Effect of: hormones on the growth and body composition of animals. Nutr. Abstr. Rev. B. 51: 521–540.Google Scholar
Goldberg, A. L., Tischler, M., De MARTINO, G. and Griffin, G. 1980. Hormonal regulation of protein degradation and synthesis in skeletal muscle. Fedn Proc. Fedn Am. Socs exp. Biol. 39: 31–36.Google ScholarPubMed
Goodman, H. M. and Schwartz, J. 1974. Growth hormone and lipid metabolism. In Handbook of Physiology. Vol. 4, Part 2 (ed. Greep, R. O. and Astwood, E. B.), pp. 211–231. Amer. Physiol. Soc., Washington, DC.Google Scholar
Hart, I. C. 1973. Basal levels of prolactin in goat blood measured throughout a 24-h period by a rapid double antibody-solid phase radioimmunoassay. J. Dairy Res. 40: 235–245.CrossRefGoogle ScholarPubMed
Hart, I. C., Flux, D. S., Andrews, P. and McNeilly, A. S. 1975. Radioimmunoassay for ovine and caprine growth hormone: its application to the measurement of basal circulating levels of growth hormone in the goat. Harm. Metab. Res. 7: 35–40.CrossRefGoogle Scholar
Jansson, J. O., Albertsson-WIKLAND, K., Eden, S., Thorgren, K. G. and Isaksson, O. 1982. Circumstantial evidence for a role of the secretory pattern of growth hormone in control of body growth, Acta endocr., Copnh. 99: 24–30.Google ScholarPubMed
MacHlin, L. J. 1972. Effect of porcine growth hormone on growth and carcass composition of the pig. J. Anim. Sci. 35: 794–800.CrossRefGoogle ScholarPubMed
Muir, L. A., Wien, Sandra, Duquette, P. F., Rickes, E. L. and Cordes, E. H. 1983. Effects of exogenous growth hormone and diethylstilbestrol on growth and carcass composition of growing lambs. J. Anim. Sci. 56: 1315–1323.CrossRefGoogle ScholarPubMed
Nielsen, J. H. 1982. Effects of growth hormone, prolactin and placental lactogen on insulin content and release, and deoxyribonucleic acid synthesis in cultured pancreatic islets. Endocrinology 110: 600–606.CrossRefGoogle ScholarPubMed
Ravault, J. P., Courot, M., Garnier, D., Pelletier, J. and Terqui, M. 1977. Effect of 2-bromo-α-ergocryptine (CB 154) on plasma prolactin, LH and testosterone levels, accessory reproductive glands and spermatogenesis in lambs during puberty. Biol. Reprod. 17: 192–197.CrossRefGoogle ScholarPubMed
Reklewska, Barbara. 1974. A note on the effect of bovine somatotrophic hormone on wool production in growing lambs. Anim. Prod. 19: 253–255.Google Scholar
Spencer, G. S. G., Garssen, G. J. and Hart, I. C. 1983. A novel approach to growth promotion using auto-immunisation against somatostatin. 1. Effects on growth and hormone levels in lambs. Livest. Prod. Sci. 10: 25–37.CrossRefGoogle Scholar
Thorner, J. S., Fluckiger, E. and Calne, D. B. 1980. The interrelationship of the nervous and endocrine systems and the role of dopamine agonist drugs. In Bromocriptine. A Clinical and Pharmacological Review, pp. 1–13. Raven Press, New York.Google Scholar
Tindal, J. S., Knaggs, G. S., Hart, I. C. and BLAKE, LAURA A. 1978. Release of growth hormone in lactating and non-lactating goats in relation to behaviour, stages of sleep, electroencephalograms, environmental stimuli and levels of prolactin, insulin, glucose and free fatty acids in the circulation. J. Endocr. 76: 333–346.CrossRefGoogle ScholarPubMed
Tucker, H. A. and Wettemann, R. P. 1976. The effects of ambient temperature and relative humidity on serum prolactin and growth hormone in heifers. Proc. Soc. exp. Biol. Med. 151: 623–626.CrossRefGoogle ScholarPubMed
Wagner, J. F. and Veenhuizen, E. L. 1978. Growth performance, carcass composition and plasma hormone levels in wether lambs when treated with growth hormone and thyrotropin. J. Anim. Sci. 45: Suppl. 1, p. 397 (Abstr.).Google Scholar
Wallace, A. L. C. 1979. The effects of hormones on wool growth. In Physiological and Environmental Limitations to Wool Growth (ed. Black, J. L. and Reis, P. J.), pp. 257–268. University of New England Publishing Unit, Armidale.Google Scholar
Wallace, A. L. C. and Bassett, J. M. 1966. Effect of sheep growth hormone on plasma insulin concentration in sheep. Metabolism 15: 95–97.CrossRefGoogle ScholarPubMed
Wheatley, I. S., Wallace, A. L. C. and Bassett, J. M. 1966. Metabolic effects of ovine growth hormone in sheep. J. Endocr. 35: 341–353.CrossRefGoogle ScholarPubMed
Wynn, P. C. 1982. Growth hormone and wool growth. Ph.D. Thesis, Univ. Sydney.Google Scholar