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Effect of nutritional growth restriction on timing of reproductive development and plasma concentrations of insulin-like growth factor-1 and growth hormone in male red deer (Cervus elaphus) reared in constant photoperiod

Published online by Cambridge University Press:  02 September 2010

C. L. Adam ,
C. E. Kyle ,
P. Young  and
T. Atkinson
C. L. Adam
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
C. E. Kyle
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
P. Young
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
T. Atkinson
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

The effect of nutritional growth restriction on reproductive development in red deer stags reared in constant photoperiod was investigated and the correlation between reproductive status and circulating concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) examined.

Stags were reared from birth in constant photoperiod (12 h light: 12 h dark). They were offered a ‘complete diet’ ad libitum until they reached 52-5 kg live weight (LW) and were then maintained at this LWby restricting daily food dry-matter intake (DMI)for either a long (LR, 26 to 51 weeks of age, no. = 5) or short (SR, 21 to 33 weeks, no. = 6) period before being returned to ad libitum feeding.

Relative to SR stags, antlers hardened later in LR stags (72·0 v. 57·5 weeks of age, P < 0·001); sustained elevations in plasma testosterone also began later (55·2 v. 38·5 weeks, P < 0·001) but at lower LW (54·0 v. 60·6 kg, P < 0·05). In both groups, the testosterone rise followed the return to ad libitum food by 4 to 5 weeks. Plasma IGF-1 was closely correlated with DMI (LR, r = 0·84, P < 0·001; SR, r = 0-93, P < 0·001) and with plasma testosterone (LR, r = 0·42, P < 0·001; SR, r = 0·38, P < 0·01). Also the increase in plasma IGF-1 preceded that of testosterone (by 2·8 (s.e. 0·94) weeks) and was associated with a transient plasma GH peak (P < 0·05) and elevated LH concentrations (SR, P < 0·01; LR, P < 0·05).

The timing of reproductive development in growth-restricted male red deer in constant photoperiod may therefore be more sensitive to DMI than LW, and changes in plasma IGF-1 concentrations are consistent with a putative permissive role in relaying this information.

Keywords

LHred deersomatomedinsomatotropintestosterone
Type
Research Article
Information
Animal Science , Volume 61 , Issue 1 , August 1995 , pp. 155 - 160
Copyright
Copyright © British Society of Animal Science 1995

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References

Adam, C. L., Kyle, C. E. and Young, P. 1992. Growth and reproductive development of red deer calves (Cervus elaphus) born out-of-season. Animal Production 55:265–270.Google Scholar
Adam, C. L., Kyle, C. E. and Young, P. 1994. Influence of prenatal photoperiod on postnatal reproductive development in male red deer (Cervus elaphus). journal Reproduction and Fertility 100:607–611.CrossRefGoogle ScholarPubMed
Adam, C. L. and Robinson, J. J. 1994. The role of nutrition and photoperiod in the timing of puberty. Proceedings of Nutrition Society 53:89–102.CrossRefGoogle ScholarPubMed
Bronson, F. H. 1986. Food-restricted, prepubertal, female rats: rapid recovery of luteinizing hormone pulsing with excess food, and full recovery of pubertal development with gonadotropin-releasing hormone. Endocrinology 118:2483–2487.CrossRefGoogle ScholarPubMed
Bruce, L. A., Atkinson, T., Hutchinson, J. S. M., Shakespear, R. A. and MacRae, J. C. 1991. The measurement of insulin-like growth factor 1 in sheep plasma. Journal of Endocrinology 128:R1–R4.CrossRefGoogle ScholarPubMed
Copeland, K. C., Kuehl, T. J. and Castracane, V. D. 1982. Pubertal endocrinology of the baboon: elevated somatomedin-C/insulin-like growth factor 1 at puberty. journal of Clinical Endocrinology and Metabolism 57:268–271.Google Scholar
Copeland, K. C., Underwood, L. E. and Van Wyk, J. J. 1980. Induction of immunoreactive somatomedin-C in human serum by growth hormone: dose response relationships and effect on chromatographic profiles. Journal of Clinical Endocrinology and Metabolism 50:690–697.CrossRefGoogle ScholarPubMed
Hamilton, W. J. and Blaxter, K. L. 1980. Reproduction in farmed red deer. 1. Hind and stag fertility. Journal Agricultural Science, Cambridge 95:261–273.CrossRefGoogle Scholar
Handelsman, D. J., Spaliviero, J. A., Scott, C. D. and Baxter, R. C. 1987. Hormonal regulation of the peripubertal surge of insulin-like growth factor-1 in the rat. Endocrinology 120:491–496.CrossRefGoogle ScholarPubMed
Hiney, J. K., Ojeda, S. R. and Dees, W. L. 1991. Insulin-like growth factor 1: a possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology 54:420–423.CrossRefGoogle ScholarPubMed
Lincoln, G. A. 1971a. Puberty in a seasonally breeding male, the red deer stag (Cervus elaphus L.). Journal of Reproduction and Fertility 25:41–54.CrossRefGoogle Scholar
Lincoln, G. A. 1971b. The seasonal reproductive changes in the red deer stag (Cervus elaphus L.). Journal of Zoology, London 163:105–123.CrossRefGoogle Scholar
MacRae, J. C., Bruce, L. A., Hovell, F. D. DeB., Hart, I. C., Inkster, J., Walker, A. and Atkinson, T. 1991. Influence of protein nutrition on the response of growing lambs to exogenous bovine growth hormone, journal of Endocrinology 130:53–61.CrossRefGoogle ScholarPubMed
Martin, G. B., Tjondronegoro, S. and Blackberry, M. A. 1994. Effects of nutrition on testicular size and the concentrations of gonadotropins, testosterone and inhibin in plasma of mature male sheep, journal of Reproduction and Fertility 101:121–128.CrossRefGoogle ScholarPubMed
Ogilvy-Stuart, A. L. and Shalet, S. M. 1992. Growth hormone and puberty, journal of Endocrinology 135:405–406.CrossRefGoogle ScholarPubMed
Ojeda, S. R. and Jameson, H. E. 1977. Developmental patterns of plasma and pituitary growth hormone (GH) in the female rat. Endocrinology 100:881–889.CrossRefGoogle ScholarPubMed
Suttie, J. M., Fennessy, P. F., Corson, I. D., Laas, F. J., Crosbie, S. F., Butler, J. H. and Gluckman, P. D. 1989. Pulsatile growth hormone insulin-like growth factors and antler development in red deer (Cervus elaphus scoticus) stags, journal of Endocrinology 121:351–360.CrossRefGoogle Scholar
Suttie, J. M., Fennessy, P. F., Crosbie, S. F., Corson, I. D., Laas, F. J., Elgar, H. J. and Lapwood, K. R. 1991a. Temporal changes in LH and testosterone and their relationship with the first antler in red deer (Cervus elaphus) stags from 3 to 15 months of age. Journal of Endocrinology 131:467–474.CrossRefGoogle Scholar
Suttie, J. M., Foster, D. L., Veenvliet, B. A., Manley, T. R. and Corson, I. D. 1991b. Influence of food intake but independence of body weight on puberty in female sheep. journal of Reproduction and Fertility 92:33–39.CrossRefGoogle ScholarPubMed
Suttie, J. M., Kostyo, J. L., Ebling, F. J. P., Wood, R. I., Bucholtz, D. C., Skottner, A., Adel, T. E., Towns, R. J. and Foster, D. L. 1991c. Metabolic interfaces between growth and reproduction. IV. Chronic pulsatile administration of growth hormone and the timing of puberty in the female sheep. Endocrinology 129:2024–2032.CrossRefGoogle ScholarPubMed
Suttie, J. M. and Simpson, A. M. 1985. Photoperiodic control of appetite, growth, antlers and endocrine status of red deer. In Biology of deer production (ed. Fennessy, P. F. and Drew, K. R.), Royal Society of Neiv Zealand, Wellington, bulletin.22, pp. 429–432.Google Scholar
Suttie, J. M., White, R. G., Breier, B. H. and Gluckman, P. D. 1991d. Photoperiod associated changes in insulin-like growth factor-1 in reindeer. Endocrinology 129:679–682.CrossRefGoogle ScholarPubMed
Thissen, J.-P., Ketelslegers, J.-M. and Underwood, L. E. 1994. Nutritional regulation of the insulin-like growth factors. Endocrine Reviews 15:80–101.Google ScholarPubMed
Werther, G. A., Hogg, A., Oldfield, B. J., McKinlay, M. J., Figdor, R. and Mendelsohn, F. A. O. 1989. Localization and characterization of insulin-like growth factor-1 receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. A distinct distribution from insulin receptors. Journal of Neuroendocrinology 1:369–377.CrossRefGoogle ScholarPubMed
Wood, R. I., Ebling, F. J. P. and Foster, D. L. 1991. Sex differences in nutritional modulation of gonadotropin secretion during development: studies in the growth-retarded lamb. Biology of Reproduction 44:632–639.CrossRefGoogle ScholarPubMed