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Effect of a supplement rich in linolenic acid added to the diet of mares on fatty acid composition of mammary secretions and the acquisition of passive immunity in the foal

Published online by Cambridge University Press:  18 August 2016

C. Duvaux-Ponter ,
M. Tournié ,
L. Detrimont ,
F. Clément ,
C. Ficheux  and
A. A. Ponter
C. Duvaux-Ponter
Affiliation:
UMR INRA-INA P-G, Physiologie de la Nutrition et Alimentation, 16 rue Claude Bernard, 75231 Paris cedex 05, France
M. Tournié
Affiliation:
UMR INRA-INA P-G, Physiologie de la Nutrition et Alimentation, 16 rue Claude Bernard, 75231 Paris cedex 05, France Haras Nationaux, Station Expérimentale, 19370 Chamberet, France
L. Detrimont
Affiliation:
UMR INRA-INA P-G, Physiologie de la Nutrition et Alimentation, 16 rue Claude Bernard, 75231 Paris cedex 05, France Haras Nationaux, Station Expérimentale, 19370 Chamberet, France
F. Clément
Affiliation:
Haras Nationaux, Station Expérimentale, 19370 Chamberet, France
C. Ficheux
Affiliation:
UMR INRA-ENVA Biologie du Développement et Reproduction, 7 avenue du Général-de-Gaulle, 94704 Maisons-Alfort, France
A. A. Ponter*
Affiliation:
UMR INRA-ENVA Biologie du Développement et Reproduction, 7 avenue du Général-de-Gaulle, 94704 Maisons-Alfort, France
*
† Corresponding author. E-mail: [email protected]
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Abstract

Due to the structure of the placenta in the horse (epitheliochorial) and the as yet un-activated immune system of the foal at birth, the transfer of maternal immunoglobulin G (IgG) is essential in the protection of the young foal until its own immune system develops. The fluidity of intestinal cell membranes may affect the transfer of IgG by receptor mediated endocytosis. In the present experiment we studied the effect of the addition of supplements rich in either alpha-linolenic acid or oleic acid to the diet of the mares starting 1·5 months before foaling and for 1 month after foaling on the passive transfer of IgG and the fatty acid composition of mammary secretions and plasma of foals. Twenty-six mares were allocated to one of two treatment groups (L: linseed supplement, no. = 13 and R: rapeseed supplement, no. = 13) according to date of foaling and live weight to produce two homogeneous groups. Mammary secretions were collected to measure IgG and fatty acid composition. Jugular blood samples were taken from the foals at time 0, 12 h, 24 h, 48 h, 1 week, 2 weeks, 3 weeks and 4 weeks after foaling to measure the concentration of IgG. A subsample of foals was used to measure the IgG absorption coefficient and the plasma fatty acid compositon. There was no effect of dietary treatment on the length of gestation, the production and transfer of IgG. Group L mares produced mammary secretions which were richer in C18: 3 and poorer in C18: 1 than group R mares (P < 0·001). Contrary to expectations the C18: 3 content of blood from foals at birth from both dietary treatments was very low and there was no difference between dietary groups. The percentage of C18: 3 and C18: 2 in fatty acids increased in foal blood only after sucking had occurred, with a difference between dietary groups (L > R). In addition, the percentages of C20: 3 and C20: 4 were higher in the foals at birth than 48 h later (P < 0·001) and at birth they were highest in the R group compared with the L group foals (P < 0·05 and P 0·10, respectively). In conclusion, the attempt to increase the supply of C18: 3 during gestation to foals and to improve the transfer of IgG post partum did not appear to succeed, perhaps because the foal uses C22: 6 (produced from C18: 3) for brain growth.

Keywords

colostrumfoalsimmunoglobulinspolyenoic fatty acids
Type
Non-ruminant nutrition, behaviour and production
Information
Animal Science , Volume 78 , Issue 3 , June 2004 , pp. 399 - 407
Copyright
Copyright © British Society of Animal Science 2004

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References

Alessandri, J. M., Arfi, T. S. and Thieulin, C. 1990. Compositional changes of lipids in relation to cell differentiation and postnatal maturation in the small intestine. Reproduction, Nutrition, Development 30: 551–576.Google Scholar
Baguma-Nibasheka, M., Brenna, J. T. and Nathanielsz, P. W. 1999. Delay of preterm delivery in sheep by omega-3 chain polyunsaturates. Biology of Reproduction 60: 698–701.Google Scholar
Chambaz, J., Ravel, D., Manier, M. C., Pepin, D., Mulliez, N. and Bereziat, G. 1985. Essential fatty acids interconversion in the human fetal liver. Biology of the Neonate 47: 136–140.Google Scholar
Chavatte-Palmer, P., Duvaux-Ponter, C. and Clément, F., 2001. Passive transfer of immunity in horses. Pferdeheilkunde 17: 669–672.Google Scholar
Christie, W. W. 1981. The effects of diet and other factors on the lipid composition of ruminant tissues and milk. In Lipid metabolism in ruminant animals (ed. Christie, W. W.), pp. 193–226. Pergamon Press Ltd, Oxford.Google Scholar
Csapo, J., Stefler, J., Martin, T. G., Makray, S. and Csapo-Kiss, Z. 1995. Composition of mare’s colostrum and milk. Fat content, fatty acid composition and vitamin content. International Dairy Journal 5: 393–402.Google Scholar
Doreau, M., Boulot, S. and Chilliard, Y. 1993. Yield and composition of milk from lactating mares: effect of body condition at foaling. Journal of Dairy Research 60: 457–466.CrossRefGoogle ScholarPubMed
Erhard, M. H., Luft, C., Remler, H. -P. and Stangassinger, M. 2001. Assessment of colostral transfer and systemic availability of immunoglobulin G in new-born foals using a newly developed enzyme-linked immunosorbent assay (ELISA) system. Journal of Animal Physiology and Animal Nutrition 85: 164–173.Google Scholar
Hansen, H. S. and Olsen, S. F. 1988. Dietary (n-3)-fatty acids, prostaglandins, and prolonged gestation in humans. Progress in Clinical Biological Research 282: 305–317.Google ScholarPubMed
Hocquette, J. -F. and Bauchart, D. 1999. Intestinal absorption, blood transport and hepatic and muscle metabolism of fatty acids in preruminant and ruminant animals. Reproduction, Nutrition, Development 39: 27–48.Google Scholar
Hoffman, R. M., Kronfeld, D. S., Herbien, J. H., Swecker, W. S., Cooper, W. L. and Harris, P. A. 1998. Dietary carbohydrates and fat influence milk composition and fatty acid profile of mare’s milk. Journal of Nutrition 128: 2708S–2711S.Google Scholar
Institut National de la Recherche Agronomique. 1990. L’alimentation des chevaux (ed. Martin-Rosset, W.). INRA éditions, Paris.Google Scholar
Jainudeen, M. R. and Hafez, E. S. E. 2000. Gestation, prenatal physiology, and parturition. In Reproduction in farm animals (ed. Hafez, E. S. E. and Hafez, B.), pp. 140–155. Lippincott Williams and Wilkins, Philadelphia.CrossRefGoogle Scholar
Kinsella, J. E. 1972. Stearyl CoA as a precursor of oleic acid and glycerolipids in mammary microsomes from lactating bovine: possible regulatory step in milk triglyceride synthesis. Lipids 7: 349–355.Google Scholar
Kruse, P. E. 1983. The importance of colostral immunoglobulins and their absorption from the intestine of the newborn animals. Annales de Recherche Vétérinaire 14: 349–353.Google ScholarPubMed
Lavoie, J. P., Spensley, M. S., Smith, B. P. and Mihalyi, J. 1989. Absorption of bovine colostrum immunoglobulins G and M in newborn foals. American Journal of Veterinary Research 50: 1598–1603.Google Scholar
Levieux, D. 1991. Dosage des IgG du lait de vache par immunodiffusion radiale semi-automatisée, pour la détection du colostrum, des laits de mammites ou de fin de gestation. I. Mise au point du dosage. Lait 71: 327–328.Google Scholar
Littell, R. C., Henry, P. R. and Ammerman, C. B. 1998. Statistical analysis of repeated measures data using SAS procedures. Journal of Animal Science 76: 1216–1231.CrossRefGoogle Scholar
Mancini, G., Carbonara, A. O. and Heremans, J. F. 1965. Immunochemical quantification of antigens by single radial immunodiffusion. Immunochemistry 2: 235–254.Google Scholar
Mattos, R., Staples, C. R. and Thatcher, W. W. 2000. Effects of dietary fatty acids on reproduction in ruminants. Reviews of Reproduction 5: 38–45.Google Scholar
Meddings, J. B. and Theisen, S. 1989. Development of rat jejunum: lipid permeability, physical properties, and chemical composition. American Journal of Physiology 256: 931–940.Google ScholarPubMed
Murphy, M. G. 1990. Dietary fatty acids and membrane protein function. Journal of Nutritional Biochemistry 1: 68–79.CrossRefGoogle ScholarPubMed
Noble, R. C., Shand, J. H. and Calvert, D. T. 1982. The role of the placenta in the supply of essential fatty acids to the fetal sheep: studies of lipid compositions at term. Placenta 3: 287–295.CrossRefGoogle Scholar
Olsen, S. F., Hansen, H. S., Sorensen, T. I., Jensen, B., Secher, N. J., Sommer, S. and Knudsen, L. B. 1986. Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. Lancet 2: 367–369.Google Scholar
Ousey, J. C., Dudan, F. and Rossdale, P. D. 1984. Preliminary studies of mammary secretions in the mare to assess foetal readiness for birth. Equine Veterinary Journal 16: 259–263.Google Scholar
Rooke, J. A. and Bland, I. M. 2002. The acquisition of passive immunity in the new-born piglet. Livestock Production Science 78: 13–23.CrossRefGoogle Scholar
Rooke, J. A., Shanks, M. and Edwards, S. A. 2000. Effect of offering maize, linseed or tuna oils throughout pregnancy and lactation on sow and piglet tissue composition and piglet performance. Animal Science 71: 289–299.Google Scholar
Schouw, Y. T. van der, Al, M. D., Hornstra, G., Bulstra-Ramakers, M. T. and Huisjes, H. J. 1991. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. Prostaglandins, Leukotrienes, and Essential Fatty Acids 44: 247–252.Google Scholar
Stammers, J. P., Hull, D., Leadon, D. P., Jeffcott, L. B. and Rossdale, P. D. 1991. Maternal and umbilical venous plasma lipid concentrations at delivery in the mare. Equine Veterinary Journal 23: 119–122.Google Scholar
Stammers, J. P., Leadon, D. P. and Hull, D. 1987. Fatty acid composition of the plasma lipids of the maternal and newborn horse. Journal of Reproduction and Fertility 35: (suppl.) 615–622.Google Scholar
Statistical Analysis Systems Institute. 1996. SAS/STAT user’s guide (release 6·12). SAS Institute Inc., Cary, NC.Google Scholar
Sukhija, P. S. and Palmquist, D. L. 1988. Rapid method for determination of total fatty acid content and composition of feedstuffs and feces. Journal of Agricultural and Food Chemistry 36: 1202–1206.Google Scholar
Sutton, J. D. and Morant, S. V. 1989. A review of the potential of nutrition to modify milk fat and protein composition. Livestock Production Science 23: 219–237.CrossRefGoogle Scholar