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Control of nutritional muscular dystrophy in lambs by selenium implantation†

Published online by Cambridge University Press:  02 September 2010

M. Hidiroglou ,
I. Hoffman ,
K. J. Jenkins  and
R. R. MacKay
M. Hidiroglou
Affiliation:
Canada Department of Agriculture, Ottawa, Ontario, Canada
I. Hoffman
Affiliation:
Canada Department of Agriculture, Ottawa, Ontario, Canada
K. J. Jenkins
Affiliation:
Canada Department of Agriculture, Ottawa, Ontario, Canada
R. R. MacKay
Affiliation:
Canada Department of Agriculture, Ottawa, Ontario, Canada
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Summary

An implantation technique utilizing slow-release selenium pellets was evaluated as a means of controlling nutritional muscular dystrophy (NMD) in sheep. Sixty ewes were fed a dystrophy-producing hay and implantations were made at mid-pregnancy (14 animals) and in late pregnancy (15 animals); the remainder were kept as controls. Selenium was determined at intervals on milk and blood samples from the ewes and on blood samples from the lambs. Various muscles were examined histologically for NMD lesions.

Selenium levels in the milk of implanted ewes were higher than controls up to the 60th day of lactation and levels in the blood of both ewes and lambs were higher than controls during nursing. Selenium implantation at mid-pregnancy resulted in higher selenium concentrations in lamb's blood at birth than implantation in late pregnancy. However, by 30 days of age and thereafter, this difference was reversed. Large variability was encountered in the blood values for implanted ewes and their lambs. While complete protection against NMD was not achieved, implantation reduced the incidence and severity of the disease. The earlier implantation gave slightly fewer deaths from NMD, but the numbers were too small to make critical comparisons.

Type
Research Article
Information
Animal Production , Volume 13 , Issue 2 , May 1971 , pp. 315 - 321
Copyright
Copyright © British Society of Animal Science 1971

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References

REFERENCES

Andrews, E. D., Hartley, W. J. and Grant, A. B. 1968. Selenium-responsive diseases of animals in New Zealand. N.Z. vet. J. 16: 3–17.Google Scholar
Gardiner, M. R. 1969. Selenium in animal nutrition. Outl. Agric. VI: 19–28.CrossRefGoogle Scholar
Godwin, O. K. 1970. Selenium and oestrogenic pastures. In Trace Element Metabolism in Animals (ed. Mills, C. F.), pp. 218–220. Livingstone, Edinburgh and London.Google Scholar
Handreck, K. A. and Godwin, K. O. 1970. Distribution in the sheep of selenium derived from 75Se-labelled ruminai pellets. Aust. J. agric. Res. 21: 71–84.Google Scholar
Hartley, W. J. 1963. Selenium and ewe fertility. Proc. N.Z. Soc. Anim. Prod. 23: 20–27.Google Scholar
Hartley, W. J. 1967. Levels of selenium in animal tissues and methods of selenium administration. In Selenium in Biomedicine (ed. Muth, O. H.), pp. 79–96. The AVI Publishing Co, Westport, Conn., U.S.A.Google Scholar
Hidiroglou, M., Hoffman, I. and Jenkins, K. J. 1969. Selenium distribution and radio-tocopherol metabolism in the pregnant ewe and foetal lamb. Can. J. Physiol. Pharmac. 47: 953–962.Google Scholar
Hidiroglou, M., Jenkins, K. J., Carson, R. B. and Mackay, R. R. 1968. Some aspects of selenium metabolism in normal and dystrophic sheep. Can.J. Anim. Sci. 48: 335–346.Google Scholar
Hjarde, W., Hellstrom, V. and Akerberg, E. 1963. The contents of tocopherol and carotene in red clover as dependent on variety, conditions of cultivation and shape of development. Acta. Agr. scand. 13: 1–16.Google Scholar
Hoffman, I., Westerby, R. J. and Hidiroglou, M. 1968. Precise fluorometric microdetermination of selenium in agriculture materials. J. Ass. off. analyt. Chem. 49: 1039–1042.Google Scholar
Jacobson, S. O. 1966. Excretion of a single dose of selenium in sheep. Acta vet. scand. 7: 226–239.CrossRefGoogle Scholar
Kuchel, R. E. and Buckley, R. A. 1969. The provision of selenium to sheep by means of heavy pellets. Aust. J. agric. Res. 20: 1099–1107.Google Scholar
Lindberg, P. and Lannek, N. 1970. Amounts of selenium in Swedish forages, soils and animal tissues. In Trace Element Metabolism in Animals (ed. Mills, C. F.), pp. 421–424. Livingstone, Edinburgh and London.Google Scholar
Oksanen, H. E. 1967. Selenium deficiency, clinical aspects and physiological responses in farm animals. In Selenium in Biomedicine (ed. Muth, O. H.), pp. 215–229. The AVI Publishing Co, Westport, Conn., U.S.A.Google Scholar
Snedecor, G. W. 1956. Statistical Methods, 5th edn.Iowa State College Press, Ames, Ia.Google Scholar
Wiener, G. 1966. Genetic and other factors in the occurrence of swayback in sheep. J. camp. Path. Ther. 76: 435–447.Google Scholar