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Concentrations of plasma hormones in relation to placental retention in Karan Swiss cows during and after induction of parturition with dexamethasone and stilboestrol dipropionate

Published online by Cambridge University Press:  02 September 2010

B. S. Prakash  and
M. L. Madan
B. S. Prakash
Affiliation:
Division of Cattle Nutrition and Physiology, National Dairy Research Institute, Karnal-132001.
M. L. Madan
Affiliation:
Division of Cattle Nutrition and Physiology, National Dairy Research Institute, Karnal-132001.
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Abstract

Five Karan Swiss cows were allowed to calve spontaneously and served as controls (Group A), while another 10 were induced to calve about 1 month prior to expected term using either 25 mg dexamethasone alone (Group B) or 25 mg dexamethasone in combination with 25 mg stilboestrol dipropionate (Group C). Blood samples were collected prior to, and for 50 days following, parturition for subsequent hormone analysis, and observations were made on the occurrence of retained placentae.

Parturition was successfully induced in all treated cows within 72 h of drug administration. Placental membranes were retained for 24 h in all treated animals and were manually removed in the farm veterinary clinic. No incidence of placental retention occurred in control cows.

Mean plasma oestradiol-17β in control cows showed a gradual rise from days 30 to 5 pre partum, followed by a sharp increase to peak value 1 day before calving. The rise in mean oestradiol-17β levels in the 2 days before parturition in controls was significantly greater than that recorded for the treated animals. A precipitous drop in plasma oestradiol-17β level occurred following parturition in all groups, with the levels staying low for the rest of the sampling period. Drug administration to animals in groups B and C resulted in a rapid and significant drop in plasma progesterone concentrations to a level similar to that for control animals at parturition. Subsequently, the plasma progesterone remained low in all treatment groups. Mean plasma cortisol levels showed a significant but transient increase at calving in control cows, but were suppressed for at least 48 h following drug administration in treated cows before exhibiting a rebound phenomenon to reach high values after calving.

It is concluded that for normal placental expulsion, oestradiol-17β levels are more critical than progesterone, and that the rise in oestradiol-17β and fall in progesterone levels pre partum must be gradual.

Type
Research Article
Information
Animal Production , Volume 40 , Issue 1 , February 1985 , pp. 1 - 9
Copyright
Copyright © British Society of Animal Science 1985

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