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Studies on lambs from lines genetically selected for low and high copper status 1. Differences in mortality

Published online by Cambridge University Press:  02 September 2010

Carol Woolliams ,
N. F. Suttle ,
J. A. Woolliams ,
D. G. Jones  and
G. Wiener
Carol Woolliams
Affiliation:
AFRC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
N. F. Suttle
Affiliation:
AFRC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
J. A. Woolliams
Affiliation:
AFRC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
D. G. Jones
Affiliation:
AFRC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
G. Wiener
Affiliation:
AFRC Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
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Abstract

Mortality and its causes were studied during two consecutive years in a total of 934 lambs. The lambs were from two lines of sheep genetically selected for low (L) and high (H) concentrations of copper (Cu) in plasma within an interbred Scottish Blackface × Welsh Mountain population and from unselected Scottish Blackface (B) and Welsh Mountain (W) breeds. The lambs grazed improved hill pastures. Half of the lambs in each line or breed were given an oral Cu supplement by 7·5 weeks of age.

Mortality from birth to 24 weeks in H was less than half that in L; mean proportional mortalities were L 0·28, H 0·12, B 0·37 and W 0·07, with a similar distribution in each year. Swayback accounted proportionately for 0·26 deaths in year 1, but proportionately for only 0·02 in year 2. The majority of other losses involved a variety of microbial infections.

Genetic type (W < H < L < B) was a major determinant of, and Cu supplementation a protection against, swayback and non-swayback losses. For non-swayback losses L lambs were about twice (P < 0·01) and B lambs about four times (P < 0·001) more vulnerable than H and W lambs respectively. Unsupplemented lambs were more than twice as vulnerable to non-swayback causes of death in the 1st year (P < 0·05) and four times as vulnerable in the 2nd year (P < 0·01) as were Cu-supplemented lambs. There were no cases of swayback in supplemented lambs even though Cu treatment was in some lambs as late as 7·5 weeks after birth.

Such marked differences in mortality rate, particularly between the selected lines, had not been apparent in the 5 years preceding pasture improvement, suggesting a genotype × environment interaction affecting survival.

The results provide the first definitive evidence that decreased resistance to infection is a clinical consequence of ovine Cu deficiency in the field, amenable to control by Cu treatment and genetic selection.

Type
Research Article
Information
Animal Production , Volume 43 , Issue 2 , October 1986 , pp. 293 - 301
Copyright
Copyright © British Society of Animal Science 1986

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References

REFERENCES

Bennetts, H. W. and Beck, A. B. 1942. Enzootic ataxia and copper deficiency of sheep in Western Australia. Bulletin, Australian Commonwealth Scientific and Industrial Research Organisation, No. 147.Google Scholar
Cowie, R. S. and Dear, J. P. 1976. Pneumonia in single suckled calves. Veterinary Record 98: 283.CrossRefGoogle ScholarPubMed
Cox, D. R. 1972. Regression models and life-tables. Journal of the Royal Statistical Society 34B: 187–220.Google Scholar
Cox, D. R. 1975. Partial likelihood. Biometrika 62: 269–276.CrossRefGoogle Scholar
Danks, D. M., Campbell, P. E., Stevens, B. J., Mayne, V. and Cartwright, E. 1972. Menkes kinky hair syndrome. An inherited defect in copper absorption with widespread effects. Pediatrics 50: 188–201.CrossRefGoogle ScholarPubMed
Falconer, D. S. 1960. Introduction to Quantitative Genetics. Longman, London.Google Scholar
Howell, J. McC., Pass, D. A. and Terlecki, S. 1981. Swayback lesions and vulnerable periods of development. Proceedings 4th International Symposium on Trace Element Metabolism in Man and Animals, pp. 298–301. Australian Academy of Science, Canberra.CrossRefGoogle Scholar
Jones, D. G. and Suttle, N. F. 1981. Some effects of copper deficiency on leucocyte function in sheep and cattle. Research in Veterinary Science 31: 151–156.CrossRefGoogle ScholarPubMed
Jones, D. G. and Suttle, N. F. 1983. The effect of copper deficiency on the resistance of mice to infection with Pasteurella haemolytica. Journal of Comparative Pathology 93: 143–149.CrossRefGoogle ScholarPubMed
Kalbfleisch, J. D. and Prentice, R. L. 1980. The Statistical Analysis of Failure Time Data. Wiley, New York.Google Scholar
Lewis, G., Terlecki, S. and Parker, B. N. J. 1974. Observations on the pathogenesis of delayed swayback. Veterinary Record 95: 313–316.CrossRefGoogle ScholarPubMed
Lukasewycz, O. A. and Prohaska, J. R. 1983. Lymphocytes from copper-deficient mice exhibit decreased mitogen reactivity. Nutrition Research 3: 335–341.CrossRefGoogle Scholar
Menkes, J. H., Alter, M., Steigleder, G. K., Weakley, D. R. and Sung, J. H. 1962. A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration. Pediatrics 29: 764–779.Google ScholarPubMed
Newberne, P. M., Hunt, C. E. and Young, V. R. 1968. The role of diet and the reticuloendothelial system in the response of rats to Salmonella typhimurium infection. British Journal of Experimental Pathology. 49: 448–457.Google Scholar
Prohaska, J. R. and Lukasewycz, O. A. 1981. Copper deficiency suppresses the immune response in mice. Science, New York 213: 559–561.CrossRefGoogle Scholar
Royal Statistical Society. 1978. The GLIM System, Release 3. Numerical Algorithms Group, Oxford.Google Scholar
Suttle, N. F. 1981. Effectiveness of orally administered cupric oxide needles in alleviating hypocupraemia in sheep and cattle. Veterinary Record 108: 417–420.CrossRefGoogle ScholarPubMed
Suttle, N. F. 1983. The nutritional basis for trace element deficiencies in ruminant livestock. In Trace Elements in Animal Production and Veterinary Practice (ed. Suttle, N. F., Gunn, R. G., Allen, W. M., Linklater, K. A. and Wiener, G.), Occasional Publication of the British Society of Animal Production No. 7, pp 19–25.Google Scholar
Suttle, N. F., Field, A. C. and Barlow, R. M. 1970. Experimental copper deficiency in sheep. Journal of Comparative Pathology 80: 151–162.CrossRefGoogle ScholarPubMed
Suttle, N. F., Jones, D. G., Woolliams, J. A., Woolliams, C. and Wiener, G. 1984. Independent growth responses to copper and selenium in lambs of different breeds on improved hill pastures. Proceedings of the Nutrition Society 43: 103A(Abstr.).Google Scholar
Suttle, N. F., Woolliams, J. A., Woolliams, C., Jones, D. G., Jones, G. and Wiener, G. 1987. Studies on lambs from lines genetically selected for low and high copper status. 3. Diagnosis and prediction of hypocuprosis. Animal Production. In press.Google Scholar
Thompson, R. 1981. Survival data and GLIM. Applied Statistics 30: 310.Google Scholar
Whitehead, J. 1980. Fitting Cox's regression model to survival data using GLIM. Applied Statistics 29: 268–275.CrossRefGoogle Scholar
Whitelaw, A., Armstrong, R. H., Evans, C. C. and Fawcett, A. R. 1979. A study of the effects of copper deficiency in Scottish Blackface lambs on improved hill pasture. Veterinary Record 104: 455–460.CrossRefGoogle ScholarPubMed
Wiener, G. 1966. Genetic and other factors in the occurrence of swayback in sheep. Journal of Comparative Pathology 76: 435–447.CrossRefGoogle ScholarPubMed
Wiener, G. and Sampford, M. R. 1969. The incidence of swayback among lambs with particular reference to genetic factors. Journal of Agricultural Science, Cambridge 73: 25–31.CrossRefGoogle Scholar
Wiener, G., Suttle, N. F., Field, A. C., Herbert, J. G. and Woolliams, J. A. 1978. Breed differences in copper metabolism in sheep. Journal of Agricultural Science, Cambridge 91: 433–441.CrossRefGoogle Scholar
Wiener, G., Woolliams, J. A., Woolliams, C. and Field, A. C. 1985. Genetic selection to produce lines of sheep differing in plasma copper concentrations. Animal Production 40: 465–473.Google Scholar
Woolliams, J. A., Suttle, N. F., Wiener, G., Field, A. C. and Woolliams, C. 1983. The long-term accumulation and depletion of copper in the liver of different breeds of sheep fed diets of differing copper content. Journal of Agricultural Science, Cambridge 100: 441–449.CrossRefGoogle Scholar
Woolliams, J. A., Wiener, G., Woolliams, C. and Suttle, N. F. 1985. Retention of copper in the liver of sheep genetically selected for high and low concentrations of copper in plasma. Animal Production 41: 219–226.Google Scholar
Woolliams, J. A., Woolliams, C., Suttle, N. F., Jones, D. G. and Wiener, G. 1986. Studies on lambs from lines genetically selected for low and high copper status. 2. Incidence of hypocuprosis on improved hill pasture. Animal Production 43: 303–317.Google Scholar
Woolliams, J. A., Woolliams, C., Wiener, G., Jones, D. G. and Suttle, N. F. 1984. An association between lamb mortality and copper status in different breeds of sheep. Proceedings of the Nutrition Society 43: 102A(Abstr).Google Scholar
Yeoman, G. H. 1983. Copper in relation to lamb losses. Veterinary Record 113: 547.Google Scholar