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A note on the concentrations of steroidal residues in tissues of mature female sheep implanted with trenbolone acetate

Published online by Cambridge University Press:  02 September 2010

L. J. MacVinish  and
H. Galbraith
L. J. MacVinish
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
H. Galbraith
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
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Abstract

Thirty-two Blackface female mature sheep weighing 45 kg on average were blocked by weight and randomly allocated 60 days before slaughter to be untreated controls (C) or subcutaneously implanted with 20 (TA1), 40 (TA2) or 60 (TA3) mg trenbolone acetate (TBA). Samples of blood were collected throughout the study and post-mortem samples of selected body tissues were analysed residues.

Concentrations in blood of 17β-hydroxy-trenbolone (TBOH) peaked within 1 to 2 weeks of implantation and declined thereafter. Concentrations in blood of oestradiol-17β (OE) were elevated and generally increased with increasing dose levels of TBA. The highest concentrations of solvent extractable residues (TBOH for group TA3) ranged from 613 ng/kg in kidney to 130 ng/kg for rib muscle. Trenbolone-17β- glucuronide was detected in liver and kidney at maximum concentrations of 157 ng/kg and 94 ng/kg respectively. Implantation with TBA had no effect on concentrations of OE in any of the post-mortem tissues examined.

Keywords

meat productionoestradiolsheeptrenbolone
Type
Research Article
Information
Animal Production , Volume 56 , Issue 2 , April 1993 , pp. 277 - 280
Copyright
Copyright © British Society of Animal Science 1993

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References

Henricks, D. M., Edwards, R. L., Champe, K. A., Gettys, T. W., Skelley, G. C. and Gimenez, T. 1982. Trenbolone, estradiol-17β and oestrone levels in plasma and tissues and live-weight gains of heifers implanted with trenbolone acetate. Journal of Animal Science 55: 1048–1056.CrossRefGoogle ScholarPubMed
Hoffman, B. 1980. Some implications for the use of anabolic agents. In Protein deposition in animals (ed. Buttery, P. J. and Lindsay, D. B.), pp. 205–214. Butterworths, London.CrossRefGoogle Scholar
Heitzmann, R. J. 1993. Veterinary drug residues: an overview of the current position in the European Community. In Safety and quality of food from animals (ed. Richardson, I. R., Wood, J. D. and Lawrence, T. L. J.). Occasional publication no. 17. British Society of Animal Production In press.CrossRefGoogle Scholar
Lamming, G. E. and co-signatories. 1987. Scientific report on anabolic agents in animal production. Veterinary Record 121: 389–392.Google Scholar
Lawes Agricultural Trust. 1977. Genstat V, Mark 4.01. Rothamsted Experimental Station, Harpenden.Google Scholar
Meissonnier, E. ed. 1983. Anabolics in animal production. Office International des Epizooties, Paris.Google Scholar
MacVinish, L. J. and Galbraith, H. 1988. The effect of implantation of trenbolone acetate and oestradiol-17β in wether lambs at two initial live weights on concentrations of steroidal residues and blood glucose, urea and thyroid hormones. Animal Production 47: 75–85.Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1988. Growth performance and body composition of wether lambs implanted at two different initial live weights with trenbolone acetate combined with oestradiol-17fS. Animal Production 47: 65–74.Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1992. Growth performance and body composition of mature female sheep implanted with trenbolone acetate. Animal Production 54: 53–58.Google Scholar
Woodward, K. N. 1991. Acceptable daily intakes for veterinary drugs. Regulatory Affairs journal 2: 787–790.Google Scholar
Yuthasastrakol, P., Palmer, W. M. and Howland, B. E. 1975. Luteinising hormone, oestrogen and progesterone levels in peripheral serum of anoestrous and cyclic ewes as determined by radioimmunoassay. Journal of Reproduction and Fertility 43: 57–65.CrossRefGoogle Scholar
Zarkawi, M., Galbraith, H. and Hutchinson, J. S. M. 1991. Influence of trenbolone acetate, zeranol and oestradiol-17β implantation on growth performance and reproductive function in beef heifers. Animal Production 52: 249–253.Google Scholar