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The effect of immunization against somatostatin and β-agonist administration alone and in combination on growth and carcass composition in young steers

Published online by Cambridge University Press:  02 September 2010

J. M. Dawson ,
J. B. Soar ,
P. J. Buttery ,
J. Craigon ,
M. Gill  and
D. E. Beever
J. M. Dawson
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham Faculty of Agricultural and Food Sciences, Sutton Bonington Campus, Loughborough LE12 5RD
J. B. Soar
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham Faculty of Agricultural and Food Sciences, Sutton Bonington Campus, Loughborough LE12 5RD
P. J. Buttery
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham Faculty of Agricultural and Food Sciences, Sutton Bonington Campus, Loughborough LE12 5RD
J. Craigon
Affiliation:
Department of Applied Biochemistry and Food Science, University of Nottingham Faculty of Agricultural and Food Sciences, Sutton Bonington Campus, Loughborough LE12 5RD
M. Gill
Affiliation:
Department of Ruminant Nutrition and Metabolism, Institute for Grassland and Environmental Research, Hurley, Maidenhead SL6 5LR
D. E. Beever
Affiliation:
Department of Ruminant Nutrition and Metabolism, Institute for Grassland and Environmental Research, Hurley, Maidenhead SL6 5LR
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Abstract

The effect of active immunization against somatostatin and β-agonist administration alone and in combination on growth, carcass composition and endocrine responses was investigated in young steers given a pelleted diet of dried grass and barley (0·7: 0·3) ad libitum for 16 weeks. Immunization alone increased growth rate by proportionately 0·10 but had no effect on plasma growth hormone (GH) or insulin-like growth factor-1 (IGF-1) concentrations (P > 0·10). Carcass protein content was unchanged but fat content tended to be increased. This was possibly associated with increased (P < 0·10) plasma insulin concentrations observed in these animals. Cimaterol administration significantly increased growth rate (P < 0·05) and carcass weight (P < 0·01). Carcass protein content was significantly (P < 0·01) increased and carcass fat was significantly (P < 0·001) reduced. Administration of cimaterol to immunized animals resulted in an enhancement of the repartitioning effect of the pagonist although growth rates were intermediate between the separate treatments. The mechanism by which this was achieved is unclear. Plasma IGF-1 concentrations tended (P < 0·10) to be lower in these animals compared with controls. Plasma insulin concentrations were also reduced (P < 0·05) in these animals. Both immunized animals and those given cimaterol alone showed an increased GH response to a single intravenous injection of growth hormone releasing factor (GRF) (P < 0·05). Animals given the combined treatment however showed a reduced response suggesting that the effects were not mediated through direct changes in GH secretion. The improved lean:fat ratio in the carcass was observed to be mediated through an enhancement of the lipolytic response to the /J-agonist with only small effects on protein accretion. It is suggested that immunoneutralization of somatostatin may increase the sensitivity of adipose tissue to lipolytic stimuli. This could occur through changes in the secretion of gastrointestinal or pancreatic hormones as a result of neutralization of the inhibitory influences of somatostatin. Further work is required to clarify these effects.

Keywords

carcass compositioncattlecimaterolsomatoliberinsomatotropin
Type
Research Article
Information
Animal Science , Volume 64 , Issue 1 , February 1997 , pp. 37 - 51
Copyright
Copyright © British Society of Animal Science 1997

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