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Shiga toxin-producing Escherichia coli in swine: the public health perspective

Published online by Cambridge University Press:  09 January 2014

Marion Tseng ,
Pina M. Fratamico ,
Shannon D. Manning  and
Julie A. Funk
Marion Tseng*
Affiliation:
College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Pina M. Fratamico
Affiliation:
Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA 19038, USA
Shannon D. Manning
Affiliation:
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
Julie A. Funk
Affiliation:
College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Shiga toxin-producing Escherichia coli (STEC) strains are food-borne pathogens that are an important public health concern. STEC infection is associated with severe clinical diseases in human beings, including hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), which can lead to kidney failure and death. Cattle are the most important STEC reservoir. However, a number of STEC outbreaks and HUS cases have been attributed to pork products. In swine, STEC strains are known to be associated with edema disease. Nevertheless, the relationship between STEC of swine origin and human illness has yet to be determined. This review critically summarizes epidemiologic and biological studies of swine STEC. Several epidemiologic studies conducted in multiple regions of the world have demonstrated that domestic swine can carry and shed STEC. Moreover, animal studies have demonstrated that swine are susceptible to STEC O157:H7 infection and can shed the bacterium for 2 months. A limited number of molecular epidemiologic studies, however, have provided conflicting evidence regarding the relationship between swine STEC and human illness. The role that swine play in STEC transmission to people and the contribution to human disease frequency requires further evaluation.

Keywords

shiga toxin-producing Escherichia coli (STEC)swinefood safety
Type
Review Article
Information
Animal Health Research Reviews , Volume 15 , Issue 1 , June 2014 , pp. 63 - 75
Copyright
Copyright © Cambridge University Press 2014 

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