Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-06T05:11:11.434Z Has data issue: false hasContentIssue false

Pharmacological considerations of antibiotic failures in bovine respiratory disease cases

Published online by Cambridge University Press:  02 December 2020

Brian V. Lubbers*
Affiliation:
Kansas State University, 1800 Denison Ave., Mosier Hall, Manhattan, KS66506, USA
*
Author for correspondence: Brian V. Lubbers, Kansas State University, 1800 Denison Ave., Mosier Hall, Manhattan, KS66506, USA. E-mail: [email protected]

Abstract

Bovine respiratory disease (BRD) is one of the most common indications for antimicrobial therapy in beef cattle production and research trials demonstrate that antibiotic therapy greatly improves clinical outcome for BRD. These trials also show that BRD treatment success rates are less than 100% and that there are opportunities to optimize antimicrobial prescribing and improve clinical outcomes if the underlying cause(s) of BRD treatment failures can be identified and addressed. As the etiology of BRD in an individual animal is frequently multi-factorial in nature; it is likely that BRD treatment failures also result from complex interactions between the drug, drug administrator, animal host, pathogens, and the environment. This review will focus specifically on the pharmacological aspects, specifically the interactions between the host and the drug and the drug and the drug administrator, of BRD treatment failures and the actions that veterinary practitioners can take to investigate and mitigate therapeutic failures in future cases.

Type
Special issue: Papers from Bovine Respiratory Disease Symposium
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cusack, PMV, McMeniman, N and Lean, IJ (2003) The medicine and epidemiology of bovine respiratory disease in feedlots. Australian Veterinary Journal 81, 480487.CrossRefGoogle ScholarPubMed
De Briyne, N, Gopal, R, Diesel, G, Iatridou, D and O'Rouke, D (2017) Veterinary pharmacovigilance in Europe: a survey of veterinary practitioners. Veterinary Record Open 4, e000224.CrossRefGoogle ScholarPubMed
Garcia, MS (2009) Early antibiotic treatment failure. International Journal of Antimicrobial Agents 34(S3), 1419.CrossRefGoogle Scholar
Goncalves-Pereira, J and Povoa, P (2011) Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of ß-lactams. Critical Care 15, R206.CrossRefGoogle Scholar
Houck, PM, Bratzler, DW, Nsa, W, Ma, A and Bartlett, JG (2004) Timing of antibiotic administration and outcomes for Medicare patients hospitalized with Community-acquired pneumonia. Archives of Internal Medicine 164, 637664.CrossRefGoogle ScholarPubMed
Martinez, M and Modric, S (2010) Patient variation in veterinary medicine: part I. Influence of altered physiologic states. Journal of Veterinary Pharmacology and Therapeutics 33, 213226.CrossRefGoogle Scholar
Ondrak, JD, Jones, ML and Fajt, VR (2015) Temperatures of storage areas in large animal veterinary practice vehicles in the summer and comparison with drug manufacturers’ storage recommendations. BMC Veterinary Research 11, 248.CrossRefGoogle ScholarPubMed
Shah, S, Barton, G and Fischer, A (2015) Pharmacokinetic considerations and dosing strategies of antibiotics in the critically ill patient. Journal of the Intensive Care Society 16, 147153.CrossRefGoogle ScholarPubMed