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Necrotic enteritis in chickens: a review of pathogenesis, immune responses and prevention, focusing on probiotics and vaccination

Published online by Cambridge University Press:  25 January 2022

Mohammadali Alizadeh Open the ORCID record for Mohammadali Alizadeh [Opens in a new window] ,
Bahram Shojadoost ,
Nitish Boodhoo ,
Jake Astill ,
Khaled Taha-Abdelaziz ,
Douglas C. Hodgins ,
Raveendra R. Kulkarni  and
Shayan Sharif
Mohammadali Alizadeh
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada
Bahram Shojadoost
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada
Nitish Boodhoo
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada
Jake Astill
Affiliation:
Artemis Technologies Inc., Guelph, Ontario, Canada
Khaled Taha-Abdelaziz
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC, 29634, USA
Douglas C. Hodgins
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada
Raveendra R. Kulkarni
Affiliation:
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA
Shayan Sharif*
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada
*
Author for correspondence: Shayan Sharif, Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, OntarioN1G 2W1, Canada. E-mail: [email protected]
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Abstract

Necrotic enteritis (NE), caused by Clostridium perfringens (CP), is one of the most common of poultry diseases, causing huge economic losses to the poultry industry. This review provides an overview of the pathogenesis of NE in chickens and of the interaction of CP with the host immune system. The roles of management, nutrition, probiotics, and vaccination in reducing the incidence and severity of NE in poultry flocks are also discussed.

Keywords

ChickensClostridium perfringensimmune responsenecrotic enteritispathogenesisprobioticsvaccination
Type
Review Article
Information
Animal Health Research Reviews , Volume 22 , Issue 2 , December 2021 , pp. 147 - 162
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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