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Histophilus somni host–parasite relationships

Published online by Cambridge University Press:  24 January 2008

Lynette B. Corbeil
Lynette B. Corbeil*
Affiliation:
Division of Infectious Diseases, Department of Pathology, University of California, San Diego, CA, USA Department of Population Health and Reproduction, University of California, Davis, CA, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Histophilus somni (Haemophilus somnus) is one of the key bacterial pathogens involved in the multifactorial etiology of the Bovine Respiratory Disease Complex. This Gram negative pleomorphic rod also causes bovine septicemia, thrombotic meningencephalitis, myocarditis, arthritis, abortion and infertility, as well as disease in sheep, bison and bighorn sheep. Virulence factors include lipooligosaccharide, immunoglobulin binding proteins (as a surface fibrillar network), a major outer membrane protein (MOMP), other outer membrane proteins (OMPs) and exopolysaccharide. Histamine production, biofilm formation and quorum sensing may also contribute to pathogenesis. Antibodies are very important in protection as shown in passive protection studies. The lack of long-term survival of the organism in macrophages, unlike facultative intracellular bacteria, also suggests that antibodies should be critical in protection. Of the immunoglobulin classes, IgG2 antibodies are most implicated in protection and IgE antibodies in immunopathogenesis. The immunodominant antigen recognized by IgE is the MOMP and by IgG2 is a 40 kDa OMP. Pathogenetic synergy of bovine respiratory syncytial virus (BRSV) and H. somni in calves can be attributed, in part at least, to the higher IgE anti-MOMP antibody responses in dually infected calves. Other antigens are probably involved in stimulating host defense or immunopathology as well.

Keywords

virulence factorsantibodiesprotectionpathogenesisHistophilus somniBovine Respiratory Diseasesyneryimmunoglobulins
Type
Review Article
Information
Animal Health Research Reviews , Volume 8 , Issue 2 , December 2007 , pp. 151 - 160
Copyright
Copyright © Cambridge University Press 2008

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References

Akerstrom, B, Nielsen, E and Bjorck, L (1987). Definition of IgG and albumin-binding regions of streptococcal protein G. Journal of Biological Chemistry 262: 13388–13391.CrossRefGoogle ScholarPubMed
Andrews, JJ, Anderson, TD, Slife, LN and Stevenson, GW (1985). Microscopic lesions associated with the isolation of Haemophilus somnus from pneumonic bovine lungs. Veterinary Pathology 22: 131–136.CrossRefGoogle ScholarPubMed
Angen, O, Ahrens, P, Kuhnert, P, Christenesen, H and Mutters, R (2003). Proposal of Histophilus somni gen. Nov., sp. Nov. for the three species incertae sedis “Haemophilus somnus,” “Haemophilus agni” and “Histophilus ovis”. International Journal of Systemic Evolutionary Microbiology 53: 1449–1456.CrossRefGoogle ScholarPubMed
Bastida-Corcuera, F, Butler, JE, Yahiro, S, Yahiro, S and Corbeil, LB (1999a). Complement activation by bovine IgG2a and IgG2b allotypes. Veterinary Immunology and Immunopathology 71: 115–123.CrossRefGoogle ScholarPubMed
Bastida-Corcuera, F, Nielsen, KH and Corbeil, LB (1999b). Binding of bovine IgG2a and IgG2b allotypes to protein A, protein G, and Haemophilus somnus IgBPs. Veterinary Immunology and Immunopathology 71: 143–149.CrossRefGoogle ScholarPubMed
Berghaus, LJ, Corbeil, LB, Berghaus, RD, Kalina, WV, Kimbal, RA and Gershwin, LJ (2006). Effects of dual vaccination for bovine respiratory syncytial virus and Haemophilus somnus on immune responses. Vaccine 24: 6018–6027.CrossRefGoogle ScholarPubMed
Behling-Kelly, E, Vonderheid, H, Kim, KS, Corbeil, LB and Czuprynski, CJ (2006). Roles of cellular activation and sulfated glycans in Haemophilus somnus adherence to bovine brain microvascular endothelial cells. Infection and Immunity 74: 5311–5318.CrossRefGoogle ScholarPubMed
Biberstein, E (1981). Haemophilus somnus and Haemophilus agni. In: Kilian, M, Frederiksen, W and Biberstein, E (Eds) Haemophilus, Pasteurella and Actinobacillus. London: Academic Press, p. 125.Google Scholar
Bjorck, L and Kronvall, G (1984). Purification and some properties of streptococcal protein G, a novel IgG-binding reagent. Journal of Immunology 133: 969–974.CrossRefGoogle ScholarPubMed
Blom, J, Hansen, GA and Poulsen, FM (1983). Morphology of cells and hemagglutinogens of Bordetella species: resolution of substructural units in fimbriae of Bordetella pertussis. Infection and Immunity 42: 308–317.CrossRefGoogle ScholarPubMed
Bryson, DG, Ball, HG, Mcaliskey, M, McConnell, W and McCullough, SJ (1990). Pathological, immunocytochemical and microbiological findings in calf pneumonias associated with Haemophilus somnus infection. Journal of Comparative Pathology 103: 433–445.CrossRefGoogle ScholarPubMed
Calvo, M, Guzman, F, Perez, E, Segura, CH, Molano, A and Patarroyo, ME (1991). Specific interactions of synthetic peptides derived from P. falciparum merozoite proteins with human red blood cells. Peptide Research 4: 324–333.Google Scholar
Challacombe, JF, Duncan, AJ, Brettin, TS, Bruce, D, Chertkov, O, Detter, JC, Han, CS, Misra, M, Richardson, P, Tapia, R, Thayer, N and Xie, G (2007). Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd. Journal of Bacteriology 189: 1890–1898.CrossRefGoogle ScholarPubMed
Cole, SP, Guiney, DG and Corbeil, LB (1992). Two linked genes for outer membrane proteins are absent in four non-disease strains of Haemophilus somnus. Molecular Microbiology 6: 1895–1902.CrossRefGoogle ScholarPubMed
Cole, SP, Guiney, DG and Corbeil, LB (1993). Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus. Journal of General Microbiology 139: 2135–2143.CrossRefGoogle ScholarPubMed
Corbeil, LB (1990). Molecular aspects of some virulence factors of Haemophilus somnus. Canadian Journal of Veterinary Research 54: S57–S62.Google ScholarPubMed
Corbeil, LB, Watt, B, Corbeil, RR, Betzen, TG, Brownson, RK and Morrill, JL (1984). Immunoglobulin concentrations in serum and nasal secretions of calves at the onset of pneumonia. American Journal of Veterinary Research 45: 773–778.Google ScholarPubMed
Corbeil, LB, Blau, K, Prieur, DJ and Ward, ACS (1985). Serum susceptibility of Haemophilus somnus from bovine clinical cases and carriers. Journal of Clinical Microbiology 22: 192–198.CrossRefGoogle Scholar
Corbeil, LB, Arthur, JE, Widders, PR, Smith, JW and Barbet, AF (1987). Antigenic specificity of convalescent serum from cattle with Haemophilus somnus induced experimental abortion. Infection and Immunity 55: 1381–1386.CrossRefGoogle ScholarPubMed
Corbeil, LB, Chikami, G, Yarnall, M, Smith, J and Guiney, DG (1988). Cloning and expression of genes encoding for Haemophilus somnus antigens. Infection and Immunity 56: 2736–2742.CrossRefGoogle ScholarPubMed
Corbeil, LB, Kania, SA and Gogolewski, RP (1991). Characterization of immunodominant surface antigens of Haemophilus somnus. Infection and Immunity 59: 4295–4301.CrossRefGoogle ScholarPubMed
Corbeil, LB, Gogolewski, RP, Stephens, LR and Inzana, TJ (1995). Haemophilus somnus: Antigen analysis and immune responses. In: Donachie, W, Lainson, FA and Hodgson, JC (eds) Haemophilus, Actinobacillus, and Pasteurella. New York, NY: Plenum Press, pp. 63–73.CrossRefGoogle Scholar
Corbeil, LB, Bastida-Corcuera, FD and Beveridge, TJ (1997a). Haemophilus somnus immunoglobulin binding proteins and surface fibrils. Infection and Immunity 65: 4250–4257.CrossRefGoogle ScholarPubMed
Corbeil, LB, Gogolewski, RP, Kacskovics, I, Nielsen, KH, Corbeil, RR, Morrill, JL, Greenwood, R and Butler, JE (1997b). Bovine IgG2a antibodies to Haemophilus somnus and allotype expression. Canadian Journal of Veterinary Research 61: 207–213.Google ScholarPubMed
Corbeil, LB, Arnold, KF, Kimball, R, Berghaus, L and Gershwin, LJ (2006). Specificity of IgG and IgE antibody responses to infection of calves. Veterinary Immunology and Immunopathology 113: 191–199.CrossRefGoogle ScholarPubMed
Cox, AD, Howard, MD, Brisson, J-R, Van Der Zwan, M, Thibault, P, Perry, MB and Inzana, TJ (1998). Structural analysis of the phase-variable lipooligosaccharide from Haemophilus somnus strain 738. European Journal of Biochemistry 253: 507–516.CrossRefGoogle ScholarPubMed
Cox, AD, Howard, MD and Inzana, TJ (2003). Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus strain 1P. Carbohydrate Research 338: 1223–1228.CrossRefGoogle ScholarPubMed
Domenighini, M, Relman, D, Capiau, C, Falkow, S, Prugnola, A, Scarlato, V and Rappuoli, R (1990). Genetic characterization of Bordetella pertussis filamentous hemagglutinin: a protein processed from an unusually large precursor. Molecular Microbiology 4: 787–800.CrossRefGoogle ScholarPubMed
Dyer, NW (2001). Haemophilus somnus bronchopneumonia in American bison (Bison bison). Journal of Veterinary Investigation 13: 419–421.CrossRefGoogle ScholarPubMed
Ekins, A and Niven, DF (2001). Production of transferrin receptors by Histophilus ovis: three of five strains require two signals. Canadian Journal of Microbiology 47: 417–423.CrossRefGoogle ScholarPubMed
Ekins, A, Bahrami, F, Sijercic, A, Mare, D and Niven, DF (2004). Haemophilus somnus possesses two systems for acquisition of transferrin-bound iron. Journal of Bacteriology 186: 4407–4411.CrossRefGoogle ScholarPubMed
Ellis, JA and Jong, C (1997). Systemic adverse reactions in young simmental calves following administration of a combined vaccine. Canadian Veterinary Journal 38: 45–47.Google Scholar
Estes, DM and Brown, WC (2002). Type 1 and type 2 responses in regulation of Ig isotype expression in cattle. Veterinary Immunology and Immunopathology 90: 1–10.CrossRefGoogle ScholarPubMed
Fahnestock, SR (1987). Newly available immunosorbent: recombinant modified streptococcal protein G. Immunochemica 1: 1–3.Google Scholar
Fahnestock, SR, Alexander, P, Nagle, J and Filpula, D (1986). Gene for an immunoglobulin-binding protein from a Group G Streptococcus. Journal of Bacteriology 167: 870–880.CrossRefGoogle ScholarPubMed
Frey, J and MacInnes, JI (1995). Genetic manipulations of members of the family Pasteurellaceae. In: Donachie, W, Lainson, FA and Hodgson, JC (eds) Haemophilus, Actinobacillus and Pasteurella. New York, NY: Plenum Press, pp. 187–195.CrossRefGoogle Scholar
Geertsema, RS, Kimbal, RA and Corbeil, LB (2007). Bovine plasma proteins increase virulence of Haemophilus somnus in mice. Microbial Pathogenesis 42: 22–28.CrossRefGoogle ScholarPubMed
Gershwin, LJ, Berghaus, LJ, Arnold, K, Anderson, ML and Corbeil, LB (2005). Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus. Veterinary Immunology and Immunopathology 107: 119–130.CrossRefGoogle ScholarPubMed
Gogolewski, RP, Kania, SA, Inzana, TJ, Widders, PR, Liggitt, HD and Corbeil, LB (1987a). Protective ability and specificity of convalescent serum from Haemophilus somnus pneumonia. Infection and Immunity 55: 1403–1411.CrossRefGoogle ScholarPubMed
Gogolewski, RP, Leathers, CW, Liggitt, HD and Corbeil, LB (1987b). Experimental Haemophilus somnus pneumonia in calves and immunoperoxidase localization of bacteria. Veterinary Pathology 24: 250–256.CrossRefGoogle ScholarPubMed
Gogolewski, RP, Kania, SA, Liggitt, HD and Corbeil, LB (1988). Protective ability of monospecific sera against 78 kDa and 40-kDa outer membrane antigens of “Haemophilus somnus”. Infection and Immunity 56: 2301–2316.CrossRefGoogle Scholar
Gogolewski, RP, Schaefer, DC, Wasson, SK, Corbeil, RR and Corbeil, LB (1989). Pulmonary persistence of Haemophilus somnus in presence of specific antibody. Journal of Clinical Microbiology 27: 1767–1774.CrossRefGoogle ScholarPubMed
Gomis, SM, Godson, DL, Beskorwayne, T, Wobeser, GA and Potter, AA (1997a). Modulation of phagocytic function of bovine mononuclear phagocytes by Haemophilus somnus. Microbial Pathogenesis 22: 13–21.CrossRefGoogle ScholarPubMed
Gomis, SM, Godson, DL, Wobeser, GA and Potter, AA (1997b). Effect of Haemophilus somnus on nitric oxide production and chemiluminescence response of bovine blood monocytes and alveolar macrophages. Microbial Pathogenesis 23: 327–333.CrossRefGoogle ScholarPubMed
Groom, S, Little, P and Rosendal, S (1988). Virulence differences among three strains of H. somnus following intratracheal inoculation of calves. Canadian Journal of Veterinary Research 52: 349–354.Google ScholarPubMed
Griner, LA, Jensen, R and Brown, WW (1956). Infectious embolic meningoencephalitis. Journal of the American Veterinary Medical Association 129: 417–421.Google Scholar
Haines, DM and Clark, EG (1991). Enzyme immunohistochemical staining of formalin fixed-tissues or diagnosis in veterinary pathology. Canadian Veterinary Journal 32: 295–302.Google ScholarPubMed
Hannah, JH, Menozzi, FD, Renauld, G, Locht, C and Brennan, MJ (1994). Sulfated glycoconjugate receptors for the Bordetella pertussis adhesin filamentious hemagglutinin (FHA) and mapping of the heparin-binding domain on FHA. Infection and Immunity 62: 5010–5019.CrossRefGoogle Scholar
Haritani, M, Nakazawa, M, Hashimoto, K, Narita, M, Tagawa, Y and Nakagawa, M (1990). Immunoperoxidase evaluation of the relationship between necrotic lesions and causative bacteria in lungs of calves with naturally acquired pneumonia. American Journal of Veterinary Research 51: 1975–1979.CrossRefGoogle ScholarPubMed
Harris, FW and Janzen, ED (1989). The Haemophilus somnus disease complex (Hemophilosis): a review. Canadian Veterinary Journal 30: 816–822.Google ScholarPubMed
Howard, MD, Cox, AD, Weiser, JN, Schurig, GG and Inzana, TJ (2000). Antigenic diversity of Haemophilus somnus lipooligosaccharide: phase-variable accessibility of the phosphorylcholine epitope. Journal of Clinical Microbiology 38: 4412–4419.CrossRefGoogle ScholarPubMed
Howard, MD, Boone, JH, Buechner-Maxwell, V, Schurig, GG and Inzana, TJ (2004). Inhibition of bovine macrophage and polymorphonuclear leukocyte superoxide anion production by Haemophilus somnus. Microbial Pathogenesis 37: 263–271.CrossRefGoogle ScholarPubMed
Humphrey, J and Stephens, L (1983). Haemophilus somnus: a review. Veterinary Bulletin 53: 987–1004.Google Scholar
Humphrey, JD, Little, PB, Stephens, LR, Barnum, DA, Doig, PA and Thorsen, J (1985). Prevalence and distribution of Haemophilus somnus in the male bovine reproductive tract. American Journal of Veterinary Research 43: 792–795.Google Scholar
Inzana, TJ, Iritani, B, Gogolewski, RP, Kania, SA and Corbeil, LB (1988). Purification and characterization of lipooligosaccharides from four strains of Haemophilus somnus. Infection and Immunity 56: 2830–2837.CrossRefGoogle ScholarPubMed
Inzana, TJ, Gogolewski, RP and Corbeil, LB (1992). Phenotypic phase variation in Haemophilus somnus lipooligosaccharide during bovine pneumonia and after in vitro passage. Infection and Immunity 60: 2943–2951.CrossRefGoogle ScholarPubMed
Inzana, TJ, Glindemann, G, Cox, AD, Wakarchuk, W and Howard, MD (2002). Incorporation of N-acetylneuraminic acid into Haemophilus somnus lipooligosaccharide (LOS): enhancement of resistance to serum and reduction of LOS antibody binding. Infection and Immunity 70: 4870–4879.CrossRefGoogle ScholarPubMed
Jackson, JA, Andrews, JJ and Hargis, JW (1987). Experimental Haemophilus somnus pneumonia in calves. Veterinary Pathology 24: 129–134.CrossRefGoogle ScholarPubMed
Jacob-Dubuisson, F, Locht, C and Antoine, R (2001). Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins. Molecular Microbiology 40: 306–313.CrossRefGoogle ScholarPubMed
Kania, SA, Gogolewski, RP and Corbeil, LB (1990). Isolation and characterization of a 78,000 dalton outer membrane protein of Haemophilus somnus. Infection and Immunity 58: 237–244.CrossRefGoogle Scholar
Khan, MdSR, Tanaka, A, Ide, H, Hoshinoo, K, Hanafusa, Y and Tagawa, Y (2005). Molecular characterization of the major outer membrane protein of Haemophilus somnus. Veterinary Microbiology 107: 179–192.CrossRefGoogle ScholarPubMed
Kuckleburg, CJ, Sylte, MJ, Inzana, TJ, Corbeil, LB, Darien, BJ and Czuprynski, CJ (2005). Bovine platelets activated by Haemophilus somnus and its LOS induce apoptosis in bovine endothelial cells. Microbial Pathogenesis 38: 23–32.CrossRefGoogle ScholarPubMed
Kwiecien, JM and Little, PB (1991). Haemophilus somnus and reproductive disease in the cow. Canadian Veterinary Journal 32: 595–601.Google ScholarPubMed
Lederer, JA, Brown, JF and Czuprynski, CJ (1987). “Haemophilus somnus,” a facultative intracellular pathogen of bovine mononuclear phagocytes. Infection and Immunity 55: 381–387.CrossRefGoogle ScholarPubMed
Lees, VW, Yates, WDG and Corbeil, LB (1994). Ovine Haemophilus somnus: experimental intracisternal infection and antigenic comparison with bovine Haemophilus somnus. Canadian Journal of Veterinary Research 58: 202–210.Google ScholarPubMed
May, BJ, Zhang, Q, Li, LK, Paustian, ML, Whittam, TS and Kapur, V (2001). Complete genomic sequence of Pasteurella multocida, Pm70. Proceedings of the National Academy of Sciences, USA 98: 3460–3465.CrossRefGoogle ScholarPubMed
McQuiston, JH, McQuiston, JR, Cox, AD, Wu, Y, Boyle, SM and Inzana, TJ (2000). Characterization of a DNA region containing 5′-(CAAT)n-3′ DNA sequences involved in lipooligosaccharide biosynthesis in Haemophilus somnus. Microbial Pathogenesis 28: 301–312.CrossRefGoogle ScholarPubMed
Michael, FS, Howard, MD, Li, J, Duncan, J, Inzana, TJ and Cox, AD (2004). Structural analysis of the lipooligosaccharide from the commensal Haemophilus somnus genome strain 129Pt. Carbohydrate Research 339: 529–535.CrossRefGoogle Scholar
Michael, FS, Li, J, Howard, MD, Duncan, AJ, Inzana, TJ and Cox, AD (2005). Structural analysis of the oligosaccharide of Histophilus somnu (Haemophilus somnus) strain 2336 and identification of several lipooligosaccharide biosynthesis gene homologues. Carbohydrate Research 340: 665–672.CrossRefGoogle Scholar
Michael, FS, Inzana, TJ and Cox, AD (2006). Structural analysis of the lipooligosaccharide-derived oligosaccharide of Histophilus somni (Haemophilus somnus) strain 8025. Carbohydrate Research 341: 281–284.CrossRefGoogle Scholar
Miller, RB, Lein, DH, McEntee, KE, Hall, CE and Shaw, S (1983). Haemophilus somnus infection of the reproductive tract of cattle: a review. Journal of the American Veterinary Medical Association 182: 1390–1392.Google ScholarPubMed
Ogunnariwo, JA, Cheng, C, Ford, J and Schryvers, AB (1990). Response to Haemophilus somnus to iron limitation: expression and identification of a bovine-specific transferring receptor. Microbial Pathogenesis 9: 397–406.CrossRefGoogle Scholar
Potgieter, LN, Helman, RG, Greene, W, Breider, MA, Thurber, ET and Peetz, RH (1988). Experimental bovine respiratory tract disease with Haemophilus somnus. Veterinary Pathology 25: 124–130.CrossRefGoogle ScholarPubMed
Prasad, SM, Yin, Y, Rodzinski, E, Tuomanen, EI and Masure, HR (1993). Identification of a carbohydrate recognition domain in filamentous hemagglutinin from Bordetella pertussis. Infection and Immunity 61: 2780–2785.CrossRefGoogle ScholarPubMed
Relman, D, Tuomanen, E, Falkow, S, Golenbock, DT, Saukkonen, K and Wright, SD (1990). Recognition of a bacterial adhesin by an integrin: Macrophage CR3 (αMβ2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell 61: 1375–1382.CrossRefGoogle Scholar
Ruby, KW, Griffith, RW, Gershwin, LJ and Caeberle, ML (2000). Haemophilus somnus-induced IgE in calves vaccinated with commercial monovalent H. somnus bacterins. Veterinary Microbiology 76: 373–383.CrossRefGoogle ScholarPubMed
Ruby, KW, Griffith, RW and Kaeberle, ML (2002). Histamine production by Haemophilus somnus. Comparative Immunology Microbiology and Infectious Diseases 25: 13–20.CrossRefGoogle ScholarPubMed
Sandal, I, Hong, W, Swords, WE and Inzana, TJ (2007). Characterization and comparison of biofilm development by pathogenic and commensal isolates of Histophilus somni. Journal of Bacteriology 189: 8179–8185, 2007.CrossRefGoogle ScholarPubMed
Sanders, JD, Cope, LD, Jarosik, GP, Maciver, I, Latimer, JL, Toews, GB and Hansen, EJ (1993). Reconstitution of a porin-deficient mutant of Haemophilus influenzae type b with a porin gene from nontypable H. influenzae. Infection and Immunity 61: 3966–3975.CrossRefGoogle Scholar
Sanders, JD, Cope, LD and Hansen, EJ (1994). Identification of a locus involved in the utilization of iron by Haemophilus influenzae. Infection and Immunity 62: 4515–4525.CrossRefGoogle ScholarPubMed
Sanders, JD, Tagawa, Y, Briggs, RE and Corbeil, LB (1997). Transformation of a virulence associated gene of Haemophilus somnus into a strain lacking the gene. FEMS Microbiology Letters 154: 241–258.CrossRefGoogle ScholarPubMed
Sanders, JD, Bastida-Corcuera, FD, Arnold, KF, Wunderlich, AC and Corbeil, LB (2003). Genetic manipulation of immunoglobulin binding proteins of Haemophilus somnus. Microbial Pathogenesis 34: 131–139.CrossRefGoogle ScholarPubMed
Shao, F, Merritt, PM, Bao, Z, Innes, RW and Dixon, JE (2002). A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell 109: 575–588.CrossRefGoogle Scholar
Siddaramappa, S and Inzana, TJ (2004). Haemophilus somnus virulence factors and resistance to host immunity. Animal Health Research Reviews 5: 79–93.Google Scholar
Step, DL, Engelken, T, Romano, C, Holland, B, Krehbiel, C, Johnson, JC, Bryson, WL, Tucker, CM and Robb, EJ (2007). Evaluation of three antimicrobial regimens used as metaphylaxis in stocker calves at high risk of developing bovine respiratory disease. Veterinary Therapy 8: 136–147.Google ScholarPubMed
Stephens, LR, Little, PB, Wilkie, BN and Barnum, DA (1981). Infectious thromboembolic meningoencephalitis in cattle: a review. Journal of the American Veterinary Medical Association 178: 378–384.Google ScholarPubMed
Sylte, MJ, Corbeil, LB, Inzana, TJ and Czuprynski, CJ (2001). Haemophilus somnus induces apoptosis in bovine endothelial cells in vitro. Infection and Immunity 69: 1650–1660.CrossRefGoogle ScholarPubMed
Sylte, MJ, Kuckleburg, CJ, Inzana, TJ, Bertics, PJ and Czuprynski, CJ (2005a). Stimulation of P2X receptors enhances lipooligosaccharide-mediates apoptosis of endothelial cells. Journal of Leukocytic Biology 77: 958–965.CrossRefGoogle ScholarPubMed
Sylte, MJ, Kuckleburg, CJ, Atapattu, D, Leite, FP, McClenahan, D, Inzana, TJ and Czuprynski, CJ (2005b). Signaling through interleukin-1 type 1 receptor diminishes Haemophilus somnus lipooligosaccharide-mediated apoptosis of endothelial cells. Microbial Pathogenesis 39: 121–130.CrossRefGoogle ScholarPubMed
Sylte, MJ, Kuckleburg, CJ, Leite, FP, Inzana, TJ and Czuprynski, CJ (2006). Tumor necrosis factor-alpha enhances Haemophilus somnus lipooligosaccharide-induced apoptosis of bovine endothelial cells. Veterinary Immunology and Immunopathology 110: 303–309.CrossRefGoogle ScholarPubMed
Tagawa, Y, Haritani, M, Ishikawa, H and Yuasa, N (1993a). Characterization of a heat-modifiable outer membrane protein of Haemophilus somnus. Infection and Immunity 61: 1750–1755.CrossRefGoogle ScholarPubMed
Tagawa, Y, Haritani, M, Ishikawa, H and Yuasa, N (1993b). Antigenic analysis of the major outer membrane protein of Haemophilus somnus with monoclonal antibodies. Infection and Immunity 61: 2257–2259.CrossRefGoogle ScholarPubMed
Tagawa, Y, Haritani, M and Yuasa, N (1993c). Characterization of an immunoreactive 17.5-kilodalton outer membrane protein of Haemophilus somnus by using a monoclonal antibody. Infection and Immunity 61: 4153–4157.CrossRefGoogle ScholarPubMed
Tagawa, Y, Ishikawa, H and Yuasa, N (1993d). Purification and partial characterization of the major outer membrane protein of Haemophilus somnus. Infection and Immunity 61: 91–96.CrossRefGoogle ScholarPubMed
Tagawa, Y, Bastida-Corcuera, FD and Corbeil, LB (2000). Immunological characterization of the major outer membrane protein of Haemophilus somnus. Veterinary Microbiology 71: 245–254.CrossRefGoogle ScholarPubMed
Tagawa, Y, Sanders, JD, Uchida, I, Bastida-Corcuera, FD, Kwashima, K and Corbeil, LB (2005). The genetic locus encoding Haemophilus somnus high molecular weight-immunoglobulin binding proteins. Microbial Pathogenesis 39: 159–170.CrossRefGoogle Scholar
Theisen, M, Rioux, CR and Potter, AA (1992). Molecular cloning, nucleotide sequence, and characterization of a 40,000-molecular-weight lipoprotein of Haemophilus somnus. Infection and Immunity 60: 826–831.CrossRefGoogle ScholarPubMed
Tegtmeier, C, Bloch, B, Jensen, NE and Jensen, HE (1999a). Initial lung lesions in two calves experimentally infected with Haemophilus somnus. Journal of Veterinary Medicine 46: 517–523.CrossRefGoogle ScholarPubMed
Tegtmeier, C, Uttenthal, A, Friis, NF, Jensen, NE and Jensen, HE (1999b). Pathological and microbiological studies on pneumonic lungs from Danish calves. Journal of Veterinary Medicine 46: 693–700.CrossRefGoogle ScholarPubMed
Vogel, GJ, Laudert, SB, Zimmermann, A, Guthrie, CA, Mechor, GD and Moore, GM (1998). Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle. Journal of the American Veterinary Medical Association 212: 1919–1924.CrossRefGoogle ScholarPubMed
Van Donkersgoed, J, Janzen, ED and Harland, RJ (1990). Epidemiological features of calf mortality due to hemophilosis in a large feedlot. Canadian Veterinary Journal 31: 821–825.Google Scholar
Ward, ACS, Jaworski, MD, Eddow, JM and Corbeil, LB (1995). A comparative study of bovine and ovine Haemophilus somnus isolates. Canadian Journal of Veterinary Research 59: 173–178.Google ScholarPubMed
Ward, ACS, Dyer, NW and Corbeil, LB (1999). Characterization of putative Haemophilus somnus isolates from American bison (Bison bison). Canadian Journal of Veterinary Research 63: 166–169.Google ScholarPubMed
Ward, ACS, Weiser, GC, Anderson, BC, Cummings, PJ, Arnold, KF and Corbeil, LB (2006). Haemophilus somnus (Histophilus somni) in bighorn sheep. Canadian Journal of Veterinary Research 70: 34–42.Google ScholarPubMed
Ward, CK, Lumbley, SR, Latimer, JL, Cope, LD and Hansen, EJ (1998). Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein. Journal of Bacteriology 180: 6013–6022.CrossRefGoogle ScholarPubMed
Widders, PR, Paisley, LG, Goglewski, RP, Evermann, JF, Smith, JW and Corbeil, LB (1986). Experimental abortion and the systemic immune response to “Haemophilus somnus” in cattle. Infection and Immunity 54: 555–560.CrossRefGoogle ScholarPubMed
Widders, PR, Smith, JW, Yarnall, M, McGuire, TC and Corbeil, LB (1988). Non-immune immunoglobulin binding of Haemophilus somnus. Journal of Medical Microbiology 26: 307–311.CrossRefGoogle ScholarPubMed
Widders, PR, Dorrance, LA, Yarnall, M and Corbeil, LB (1989). Immunoglobulin-binding activity among pathogenic and carrier isolates of H. somnus. Infection and Immunity 57: 639–642.CrossRefGoogle Scholar
Won, J and Griffith, RW (1993). Cloning and sequencing of the gene encoding a 31-Kilodalton antigen of Haemophilus somnus. Infection and Immunity 61: 2813–2821.CrossRefGoogle ScholarPubMed
Wu, Y, McQuiston, NH, Cox, A, Pack, TD and Inzana, TJ (2000). Molecular cloning and mutagenesis of a DNA locus involved in lipooligosaccharide biosynthesis in Haemophilus somnus. Infection and Immunity 68: 310–319.CrossRefGoogle ScholarPubMed
Yarnall, M and Corbeil, LB (1989). Antibody response to an Haemophilus somnus Fc receptor. Journal of Clinical Microbiology 27: 111–117.CrossRefGoogle Scholar
Yarnall, M, Gogolewski, RP and Corbeil, LB (1988a). Characterization of two Haemophilus somnus Fc receptors. Journal of General Microbiology 134: 1993–1999.Google ScholarPubMed
Yarnall, M, Widders, PR and Corbeil, LB (1988b). Isolation and characterization of Fc receptors from Haemophilus somnus. Scandinavian Journal of Immunology 28: 129–137.CrossRefGoogle ScholarPubMed
Yu, R-H, Gray-Owen, SD, Ogunnariwo, J and Schryvers, AB (1992). Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus. Infection and Immunity 60: 2992–2994.CrossRefGoogle ScholarPubMed