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Bacteriophages for prophylaxis and therapy in cattle, poultry and pigs

Published online by Cambridge University Press:  22 December 2008

R. P. Johnson ,
C. L. Gyles ,
W. E. Huff ,
S. Ojha ,
G. R. Huff ,
N. C. Rath  and
A. M. Donoghue
R. P. Johnson*
Affiliation:
Public Health Agency of Canada, Laboratory for Foodborne Zoonoses, Guelph, Ontario, N1G 3W4, Canada
C. L. Gyles
Affiliation:
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
W. E. Huff
Affiliation:
USDA, ARS, Poultry Production and Product Safety Research Unit, Poultry Science Center, University of Arkansas, Fayetteville, AR7270, USA
S. Ojha
Affiliation:
Public Health Agency of Canada, Laboratory for Foodborne Zoonoses, Guelph, Ontario, N1G 3W4, Canada
G. R. Huff
Affiliation:
USDA, ARS, Poultry Production and Product Safety Research Unit, Poultry Science Center, University of Arkansas, Fayetteville, AR7270, USA
N. C. Rath
Affiliation:
USDA, ARS, Poultry Production and Product Safety Research Unit, Poultry Science Center, University of Arkansas, Fayetteville, AR7270, USA
A. M. Donoghue
Affiliation:
USDA, ARS, Poultry Production and Product Safety Research Unit, Poultry Science Center, University of Arkansas, Fayetteville, AR7270, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

The successful use of virulent (lytic) bacteriophages (phages) in preventing and treating neonatal enterotoxigenic Escherichia coli infections in calves, lambs and pigs has prompted investigation of other applications of phage therapy in food animals. While results have been very variable, some indicate that phage therapy is potentially useful in virulent Salmonella and E. coli infections in chickens, calves and pigs, and in control of the food-borne pathogens Salmonella and Campylobacter jejuni in chickens and E. coli O157:H7 in cattle. However, more rigorous and comprehensive research is required to determine the true potential of phage therapy. Particular challenges include the selection and characterization of phages, practical modes of administration, and development of formulations that maintain the viability of phages for administration. Also, meaningful evaluation of phage therapy will require animal studies that closely represent the intended use, and will include thorough investigation of the emergence and characteristics of phage resistant bacteria. As well, effective use will require understanding the ecology and dynamics of the endemic and therapeutic phages and their interactions with target bacteria in the farm environment. In the event that the potential of phage therapy is realized, adoption will depend on its efficacy and complementarity relative to other interventions. Another potential challenge will be regulatory approval.

Keywords

Escherichia coliSalmonellaCampylobacterStaphylococcusO157:H7bacteriophagebacteriophage therapy
Type
Review Article
Information
Animal Health Research Reviews , Volume 9 , Issue 2: Symposium on Antimicrobial Resistance in Bacteria from Animals , December 2008 , pp. 201 - 215
Copyright
Copyright © Cambridge University Press 2008

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