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Antimicrobials and BRD

Published online by Cambridge University Press:  15 December 2009

Mike Apley
Mike Apley*
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
*
E-mail: [email protected]
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Abstract

Pharmacodynamics is limited with respect to its ability to provide precise predictions to guide therapy because of complications related to the bound versus unbound state of the agent, tissue versus plasma concentrations, drug degradation over time, variations among microorganisms, and factors associated with the specific environment at the infection site. Antimicrobial susceptibility testing is likewise imprecise when applied to an individual animal; however, it is valuable on an animal population basis.

Keywords

pharmacodynamicsantimicrobial suspectibility
Type
Review Article
Information
Animal Health Research Reviews , Volume 10 , Issue 2 , December 2009 , pp. 159 - 161
Copyright
Copyright © Cambridge University Press 2009

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References

CLSI Publication M31-A3 – Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals; Approved Standard – Third Edition. CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087–1898, USA. Available online at webstore.ansi.orgGoogle Scholar
CLSI Publication M37-A3 – Development of In Vitro Susceptibility Testing Criteria and Quality Control Parameters for Veterinary Antimicrobial Agents; Approved Guideline – Third Edition. CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087–1898, USA. Available online at webstore.ansi.orgGoogle Scholar