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Antimicrobial resistance and prudent drug use for Streptococcus suis

Published online by Cambridge University Press:  20 May 2013

Norma P. Varela ,
Pierre Gadbois ,
Claude Thibault ,
Marcelo Gottschalk ,
Paul Dick  and
Jeff Wilson
Norma P. Varela
Affiliation:
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, CanadaN1G 2W1 Novometrix Research Inc., RR 1, Moffat, Ontario, CanadaL0P 1J0
Pierre Gadbois
Affiliation:
Vétoquinol Canada Inc., 2000 Chemin Georges, Lavaltrie, Québec, CanadaJ0K 1H0
Claude Thibault
Affiliation:
Vétoquinol Canada Inc., 2000 Chemin Georges, Lavaltrie, Québec, CanadaJ0K 1H0
Marcelo Gottschalk
Affiliation:
Faculty of Veterinary Medicine, Université de Montréal, Québec, CanadaJ2S 2M2
Paul Dick
Affiliation:
Paul Dick and Associates, 326 Gordon Street, Guelph, Ontario, CanadaN1G 1X6
Jeff Wilson*
Affiliation:
Novometrix Research Inc., RR 1, Moffat, Ontario, CanadaL0P 1J0
*
*Corresponding author. E-mail: [email protected]
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Abstract

This paper reviews information on antimicrobial resistance patterns and prudent use of antimicrobials to reduce the impact and spread of resistant Streptococcus suis strains. S. suis is an important pathogen in swine, which can cause significant economic loss. Prudent use of antimicrobials for S. suis is essential to preserve the therapeutic efficacy of broad-spectrum antimicrobials and to minimize selection of resistant S. suis strains. Resistance of S. suis to antimicrobials commonly used in swine, including lincosamides, macrolides, sulphonamides, and tetracycline, has been documented worldwide, with resistance in up to 85% of strains. Among antimicrobials examined, resistance of S. suis has been demonstrated to be relatively low for penicillin (0–27%), ampicillin (0.6–23%), and ceftiofur (0–23%). For penicillin, this result may be due in part to the unique mechanism by which resistance is acquired through modifications in the structure of penicillin-binding proteins. Recommendations to control S. suis infection include focused and careful choice and appropriate use of antimicrobials, together with preventive measures intended to improve swine management.

Keywords

Streptococcus suisprudent useantimicrobial resistanceserotype 2
Type
Review Article
Information
Animal Health Research Reviews , Volume 14 , Issue 1 , June 2013 , pp. 68 - 77
Copyright
Copyright © Cambridge University Press 2013 

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