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Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics

Published online by Cambridge University Press:  05 November 2008

Yongming Sang  and
Frank Blecha
Yongming Sang
Affiliation:
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
Frank Blecha*
Affiliation:
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
*
*Corresponding author. E-mail: [email protected]
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Abstract

Antimicrobial peptides (AMPs) are ubiquitous, gene-encoded natural antibiotics that have gained recent attention in the search for new antimicrobials to combat infectious disease. In multicellular organisms, AMPs, such as defensins and cathelicidins, provide a coordinated protective response against infection and are a principal component of innate immunity in vertebrates. In unicellular organisms, AMPs, such as bacteriocins, function to suppress competitor species. Because many AMPs kill bacteria by disruption of membrane integrity and are thus thought to be less likely to induce resistance, AMPs are being extensively evaluated as novel antimicrobial drugs. This review summarizes and discusses the antibiotic properties of AMPs highlighting their potential as alternatives to conventional antibiotics.

Keywords

antibioticsantimicrobial peptidesbacteriocinanimal health
Type
Review Article
Information
Animal Health Research Reviews , Volume 9 , Issue 2: Symposium on Antimicrobial Resistance in Bacteria from Animals , December 2008 , pp. 227 - 235
Copyright
Copyright © Cambridge University Press 2008

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