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Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets

Published online by Cambridge University Press:  15 June 2011

J. Zentek ,
S. Buchheit-Renko ,
F. Ferrara ,
W. Vahjen ,
A. G. Van Kessel  and
R. Pieper
J. Zentek*
Affiliation:
Department of Veterinary Medicine, Institute of Animal Nutrition, Freie Universität Berlin, Brümmerstrasse 34, 14195 Berlin, Germany
S. Buchheit-Renko
Affiliation:
Department of Veterinary Medicine, Institute of Animal Nutrition, Freie Universität Berlin, Brümmerstrasse 34, 14195 Berlin, Germany
F. Ferrara
Affiliation:
Department of Veterinary Medicine, Institute of Animal Nutrition, Freie Universität Berlin, Brümmerstrasse 34, 14195 Berlin, Germany
W. Vahjen
Affiliation:
Department of Veterinary Medicine, Institute of Animal Nutrition, Freie Universität Berlin, Brümmerstrasse 34, 14195 Berlin, Germany
A. G. Van Kessel
Affiliation:
Department for Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada
R. Pieper
Affiliation:
Department of Veterinary Medicine, Institute of Animal Nutrition, Freie Universität Berlin, Brümmerstrasse 34, 14195 Berlin, Germany
*
*Corresponding author. E-mail: [email protected]
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Abstract

Medium-chain fatty acids (MCFAs) are found at higher levels in milk lipids of many animal species and in the oil fraction of several plants, including coconuts, palm kernels and certain Cuphea species. Medium-chain triglycerides (MCTs) and fatty acids are efficiently absorbed and metabolized and are therefore used for piglet nutrition. They may provide instant energy and also have physiological benefits beyond their energetic value contributing to several findings of improved performance in piglet-feeding trials. MCTs are effectively hydrolyzed by gastric and pancreatic lipases in the newborn and suckling young, allowing rapid provision of energy for both enterocytes and intermediary hepatic metabolism. MCFAs affect the composition of the intestinal microbiota and have inhibitory effects on bacterial concentrations in the digesta, mainly on Salmonella and coliforms. However, most studies have been performed in vitro up to now and in vivo data in pigs are still scarce. Effects on the gut-associated and general immune function have been described in several animal species, but they have been less studied in pigs. The addition of up to 8% of a non-esterified MCFA mixture in feed has been described, but due to the sensory properties this can have a negative impact on feed intake. This may be overcome by using MCTs, allowing dietary inclusion rates up to 15%. Feeding sows with diets containing 15% MCTs resulted in a lower mortality of newborns and better development, particularly of underweight piglets. In conclusion, MCFAs and MCTs offer advantages for the improvement of energy supply and performance of piglets and may stabilize the intestinal microbiota, expanding the spectrum of feed additives supporting piglet health in the post-weaning period.

Keywords

pigletsmedium-chain fatty acidsmedium-chain triglyceridesmetabolismantibacterial effectsimmune system
Type
Review Article
Information
Animal Health Research Reviews , Volume 12 , Issue 1 , June 2011 , pp. 83 - 93
Copyright
Copyright © Cambridge University Press 2011

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References

Allee, GL, Romsos, DR, Leveille, GA and Baker, DH (1972). Metabolic consequences of dietary medium-chain triglycerides in the pig. Proceedings of the Society Experimental Biology and Medicine 139: 422–427.CrossRefGoogle ScholarPubMed
Ashbrook, JD, Spectro, AA, Fletcher, JE, Ashbrook, JD, Spectro, AA and Fletcher, JE (1972). Medium chain fatty acid binding to human plasma albumin. Journal of Biological Chemistry 247: 7038–7042.CrossRefGoogle ScholarPubMed
Azain, MJ (1993). Effects of adding medium-chain triglycerides to sow diets during late gestation and early lactation on litter performance. Journal of Animal Science 71: 3011–3019.CrossRefGoogle ScholarPubMed
Bach, AC and Babayan, VK (1982). Medium-chain triglycerides: an update. American Journal of Clinical Nutrition 36: 950–962.CrossRefGoogle ScholarPubMed
Bailey, M, Clarke, CJ, Wilson, AD, Williams, NA and Stokes, CR (1992). Depressed potential for interleukin-2 production following early weaning of piglets. Veterinary Immunology and Immunopathology 34: 197–207.CrossRefGoogle ScholarPubMed
Bergsson, G, Arnfinnsson, J, Karlsson, SM, Steingrímsson, O and Thormar, H (1998). In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrobial Agents and Chemotherapy 42: 2290–2294.CrossRefGoogle ScholarPubMed
Bergsson, G, Steingrimsson, O and Thormar, H (1999). In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides. Antimicrobial Agents and Chemotherapy 43: 2790–2792.CrossRefGoogle ScholarPubMed
Bergsson, G, Steingrímsson, Ó and Thormar, H (2002). Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. International Journal of Antimicrobial Agents 20: 258–262.CrossRefGoogle ScholarPubMed
Bloch, R (1974). Intestinal absorption of medium-chain fatty acids. Zeitschrift fur Ernahrungswissenschaft 13: 42–49.Google Scholar
Borum, PR (1992). Medium-chain triglycerides in formula for preterm neonates: implications for hepatic and extrahepatic metabolism. Journal of Pediatrics 120: S139–S145.CrossRefGoogle ScholarPubMed
Buchheit, S (2009). Medium-chain fatty acid as feed additives in weaned piglets. Thesis, Department of Veterinary Medicine, Freie Universität, Berlin.Google Scholar
Butler, JE, Lager, KM, Splichal, I, Francis, D, Kacskovics, I, Sinkora, M, Wertz, N, Sun, J, Zhao, Y, Brown, WR, Dewald, R, Dierks, S, Muyldermans, S, Lunney, JK, McCray, PB, Rogers, CS, Welsh, MJ, Navarro, P, Klobasa, F, Habe, F and Ramsoondar, J (2009). The piglet as a model for B cell and immune system development. Veterinary Immunology and Immunopathology 128: 147–170.CrossRefGoogle Scholar
Canas-Rodriguez, A and Smith, HW (1966). The identification of the antimicrobial factors of the stomach contents of sucking rabbits. Biochemical Journal 100: 79–82.CrossRefGoogle ScholarPubMed
Carnielli, VP, Rossi, K, Badon, T, Gregori, B, Verlato, G, Orzali, A and Zacchello, F (1996). Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. American Journal of Clinical Nutrition 64: 152–158.CrossRefGoogle ScholarPubMed
Carvajal, O, Nakayama, M, Kishi, T, Sato, M, Ikeda, I, Sugano, M and Imaizumi, K (2000). Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats. Lipids 35: 1345–1351.CrossRefGoogle ScholarPubMed
Cera, KR, Mahan, DC and Reinhart, GA (1989). Postweaning Swine performance and serum profile responses to supplemental medium-chain free fatty acids and tallow. Journal of Animal Science 67: 2048–2055.CrossRefGoogle Scholar
Cox, AB, Rawlinson, LA, Baird, AW, Bzik, V and Brayden, DJ (2008). In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. Typhimurium in rat intestinal ileal mucosae. Pharmaceutical Research 25: 114–122.CrossRefGoogle Scholar
Decuypere, JA and Dierick, NA (2003). The combined use of triacylglycerols containing medium-chain fatty acids and exogenous lipolytic enzymes as an alternative to in-feed antibiotics in piglets: concept, possibilities and limitations. An overview. Nutrition Research Reviews 16: 193–210.CrossRefGoogle ScholarPubMed
Dierick, NA, Decuypere, JA, Degeyter, I and Dierick, NA (2003). The combined use of whole Cuphea seeds containing medium chain fatty acids and an exogenous lipase in piglet nutrition. Archiv für Tierernährung 57: 49–63.Google Scholar
Dierick, NA, Decuypere, JA, Molly, K, Beek, EV and Vanderbeke, E (2002). The combined use of triacylglycerols (TAGs) containing medium chain fatty acids (MCFAs) and exogenous lipolytic enzymes as an alternative to nutritional antibiotics in piglet nutrition. II. In vivo release of MCFAs in gastric cannulated and slaughtered piglets by endogenous and exogenous lipases; effects on the luminal gut flora and growth performance. Livestock Production Science 76: 1–16.CrossRefGoogle Scholar
Dove, CR (1993). The effect of adding copper and various fat sources to the diets of weanling swine on growth performance and serum fatty acid profiles. Journal of Animal Science 71: 2187–2192.CrossRefGoogle Scholar
Freese, E, Sheu, CW and Galliers, E (1973). Function of lipophilic acids as antimicrobial food additives. Nature 241: 321–325.CrossRefGoogle ScholarPubMed
Graham, SA (1989). Cuphea: a new plant source of medium-chain fatty acids. CRC Critical Reviews in Food Science and Nutrition 28: 139–173.CrossRefGoogle ScholarPubMed
Graham, SA, Hirsinger, F and Röbbelen, G (1981). Fatty acids of Cuphea (Lythraceae) seed lipids and their systematic significance. American Journal of Botany 68: 908–917.CrossRefGoogle Scholar
Greenberger, NJ and Skillmann, TG (1969). Medium chain triglycerides. Physiologic considerations and clinical implications. New England Journal of Medicine 280: 1045–1058.CrossRefGoogle Scholar
Gu, X and Li, D (2003). Fat nutrition and metabolism in piglets: a review. Animal Feed Science and Technology 109: 151–170.CrossRefGoogle Scholar
Guillot, E, Lemarchal, P and Dhorne, T (1994). Intestinal absorption of medium chain fatty acids: in vivo studies in pigs devoid of exocrine pancreatic secretion. British Journal of Nutrition 72: 545–553.CrossRefGoogle ScholarPubMed
Guillot, B, Vaugelade, P, Lemarchal, P and Rerat, A (1993). Intestinal absorption and liver uptake of medium-chain fatty acids in non-anaesthetized pigs. British Journal of Nutrition 69: 431–442.CrossRefGoogle ScholarPubMed
Hara, Y, Miura, S, Komoto, S, Inamura, T, Koseki, S, Watanabe, C, Hokari, R, Tsuzuki, Y, Ogino, T, Nagata, H, Hachimura, S, Kaminogawa, S and Ishii, H (2003). Exposure to fatty acids modulates interferon production by intraepithelial lymphocytes. Immunology Letters 86: 139–148.CrossRefGoogle ScholarPubMed
Heird, WC, Jensen, CL, Gomez, MR, Heird, WC, Jensen, CL and Gomez, MR (1992). Practical aspects of achieving positive energy balance in low birth weight infants. Journal of Pediatrics 120: S120–S128.CrossRefGoogle ScholarPubMed
Heo, KN, Lin, X, Han, IK and Odle, J (2002). Medium-chain fatty acids but not L-carnitine accelerate the kinetics of 14C triacylglycerol utilization by colostrum-deprived newborn pigs. Journal of Nutrition 132: 1989–1994.CrossRefGoogle Scholar
Hill, JO, Peters, JC, Swift, LL, Yang, D, Sharp, T, Abumrad, N and Greene, HL (1990). Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. Journal of Lipid Research 31: 407–416.CrossRefGoogle ScholarPubMed
Hoshimoto, A, Suzuki, Y, Katsuno, T, Nakajima, H and Saito, Y (2002). Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. British Journal of Pharmacology 136: 280–286.CrossRefGoogle ScholarPubMed
Hsiao, C-P and Siebert, KJ (1999). Modeling the inhibitory effects of organic acids on bacteria. International Journal of Food Microbiology 47: 189–201.CrossRefGoogle ScholarPubMed
HSDB (2011). Dodecanoic acid. http://toxnet.nlm.nih.gov/. Accessed 25 May 2011.Google Scholar
Isaacs, CE, Litov, RE and Thormar, H (1995). Antimicrobial activity of lipids added to human milk, infant formula, and bovine milk. Journal of Nutritional Biochemistry 6: 362–366.CrossRefGoogle ScholarPubMed
Jean, K-B and Chiang, S-H (1999). Increased survival of neonatal pigs by supplementing medium-chain triglycerides in late-gestating sow diets. Animal Feed Science and Technology 76: 241–250.CrossRefGoogle Scholar
Kabara, JJ, Swieczkowski, DM, Conley, AJ and Truant, JP (1972). Fatty acids and derivatives as antimicrobial agents. Antimicrobial agents and chemotherapy 2: 23–28.CrossRefGoogle ScholarPubMed
van Kempen, TATG and Odle, J (1993). Medium-chain fatty acid oxidation in colostrum-deprived newborn piglets: stimulative effect of L-carnitine supplementation. Journal of Nutrition 123: 1531–1537.CrossRefGoogle ScholarPubMed
Kenyon, MA and Hamilton, JA (1994). 13C NMR studies of the binding of medium-chain fatty acids to human serum albumin. Journal of Lipid Research 35: 458–467.CrossRefGoogle ScholarPubMed
Kono, H, Fujii, H, Asakawa, M, Maki, A, Amemiya, H, Hirai, Y, Matsuda, M and Yamamoto, M (2004). Medium-chain triglycerides enhance secretory IgA expression in rat intestine after administration of endotoxin. American Journal of Physiology, Gastrointestinal and Liver Physiology 286: G1081–G1089.CrossRefGoogle ScholarPubMed
Konstantinov, SR and Smidt, H (2006). Commensal microbiota is required for the normal development and function of the porcine host immune system and physiology. In: Mengheri, E, Britti, MS and Finamore, A (eds) Nutrition and Immunity. Kerala: Research Signpost, pp. 23–38.Google Scholar
Lalles, JP, Bosi, P, Smidt, H and Stokes, CR (2007). Nutritional management of gut health in pigs around weaning. Proceedings of the Nutrition Society 66: 260–268.CrossRefGoogle ScholarPubMed
Lallès, JP, Bosi, P, Smidt, H and Stokes, CR (2007). Weaning – a challenge to gut physiologists. Livestock Science 108: 82–93.CrossRefGoogle Scholar
Libertini, LJ and Smith, S (1978). Purification and properties of a thioesterase from lactating rat mammary gland which modifies the product specificity of fatty acid synthetase. Journal of Biological Chemistry 253: 1393–1401.CrossRefGoogle ScholarPubMed
Lin, CL, Chiang, SH and Lee, HF (1995). Causes of reduced survival of neonatal pigs by medium-chain triglycerides: blood metabolite and behavioral activity approaches. Journal of Animal Science 73: 2019–2025.CrossRefGoogle ScholarPubMed
Mabayo, RT, Furuse, M, Yang, S-I and Okumura, J-I (1992). Medium-chain triacylglycerols enhance release of cholecystokinin in chicks. Journal of Nutrition 122: 1702–1705.CrossRefGoogle ScholarPubMed
Maertens, L (1998). Fats in rabbit nutrition: a review. World Rabbit Science 6: 341–348.Google Scholar
Marten, B, Pfeuffer, M and Schrezenmeir, J (2006). Medium-chain triglycerides (special issue: technological and health aspects of bioactive components of milk). International Dairy Journal 16: 1374–1382.CrossRefGoogle Scholar
Messens, W, Goris, J, Dierick, N, Herman, L and Heyndrickx, M (2010). Inhibition of Salmonella Typhimurium by medium-chain fatty acids in an in vitro simulation of the porcine cecum. Veterinary Microbiology 141: 73–80.CrossRefGoogle Scholar
Miller, BG, James, PS, Smith, MW and Bourne, FJ (1986). Effect of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. Journal of Agricultural Science, UK 107: 579–589.CrossRefGoogle Scholar
Montagne, L, Boudry, G, Favier, C, Huerou-Luron, IL, Lalles, JP and Seve, B (2007). Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning. British Journal of Nutrition 97: 45–57.CrossRefGoogle ScholarPubMed
Mroz, Z, Koopmans, SJ, Bannink, A, Partanen, K, Krasucki, W, Overland, M and Radcliffe, S (2006). Carboxylic acids as bioregulators and gut growth promoters in nonruminants. In: Mosenthin, R, Zentek, J and Zebrowska, T (eds) Biology of Nutrition in Growing Animals (Biology of Growing Animals Series volume 4). Edinburgh: Elsevier, pp. 81–133.CrossRefGoogle Scholar
Nandi, S, Gangopadhyay, S and Ghosh, S (2005). Production of medium chain glycerides from coconut and palm kernel fatty acid distillates by lipase-catalyzed reactions. Enzyme and Microbial Technology 36: 725–728.CrossRefGoogle Scholar
Newcomb, MD, Harmon, DL, Nelssen, JL, Thulin, AJ and Allee, GL (1991). Effect of energy source fed to sows during late gestation on neonatal blood metabolite homeostasis, energy stores and composition. Journal of Animal Science 69: 230–236.CrossRefGoogle ScholarPubMed
Newport, MJ, Storry, JE and Tuckley, B (1979). Artificial rearing of pigs. British Journal of Nutrition 41: 85–93.CrossRefGoogle ScholarPubMed
Odle, J (1997). New insights into the utilization of medium-chain triglycerides by the neonate: observations from a piglet model. Journal of Nutrition 127: 1061–1067.CrossRefGoogle ScholarPubMed
Odle, J, Benevenga, NJ and Crenshaw, TD (1989). Utilization of medium-chain triglycerides by neonatal piglets: II. Effects of even- and odd-chain triglyceride consumption over the first 2 days of life on blood metabolites and urinary nitrogen excretion. Journal of Animal Science 67: 3340–3351.CrossRefGoogle ScholarPubMed
Odle, J, Benevenga, NJ and Crenshaw, TD (1991a). Postnatal age and the metabolism of medium- and long-chain fatty acids by isolated hepatocytes from small-for-gestational-age and appropriate-for-gestational-age piglets. Journal of Nutrition 121: 615–621.CrossRefGoogle Scholar
Odle, J, Benevenga, NJ and Crenshaw, TD (1991b). Utilization of medium-chain triglycerides by neonatal piglets: chain length of even- and odd-carbon fatty acids and apparent digestion/absorption and hepatic metabolism. Journal of Nutrition 121: 605–614.CrossRefGoogle ScholarPubMed
Odle, J, Lin, X, Wieland, TM and Kempen, TATGV (1994). Emulsification and fatty acid chain length affect the kinetics of 14C-medium-chain triacylglycerol utilization by neonatal piglets. Journal of Nutrition 124: 84–93.CrossRefGoogle ScholarPubMed
Petschow, BW, Batema, RP, Talbott, RD and Ford, LL (1998). Impact of medium-chain monoglycerides on intestinal colonisation by Vibrio cholerae or enterotoxigenic Escherichia coli. Journal of Medical Microbiology 47: 383–389.CrossRefGoogle ScholarPubMed
Playoust, MR and Isselbacher, KJ (1964). Studies on the intestinal absorption and intramucosal lipolysis of a medium chain triglyceride. Journal of Clinical Investigation 43: 878–885.CrossRefGoogle ScholarPubMed
Pluske, JR, Hampson, DJ and Williams, IH (1997). Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livestock Production Science 51: 215–236.CrossRefGoogle Scholar
Ramirez, M, Amate, L and Gil, A (2001). Absorption and distribution of dietary fatty acids from different sources. Early Human Development 65 (suppl.): S95–S101.CrossRefGoogle ScholarPubMed
Rasmussen, BB, Holmback, UC, Volpi, E, Morio-Liondore, B, Paddon-Jones, D and Wolfe, RR (2002). Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. Journal of Clinical Investigation 110: 1687–1693.CrossRefGoogle ScholarPubMed
Reiner, DS, Wang, CS and Gillin, FD (1986). Human milk kills Giardia lamblia by generating toxic lipolytic products. Journal of Infectious Diseases 154: 825–832.CrossRefGoogle ScholarPubMed
Rooke, JA and Bland, IM (2002). The acquisition of passive immunity in the new-born piglet (special issue: peri- and post-natal mortality in the Pig). Livestock Production Science 78: 13–23.CrossRefGoogle Scholar
Rudolph, M, Neville, M and Anderson, S (2007). Lipid synthesis in lactation: diet and the fatty acid switch. Journal of Mammary Gland Biology and Neoplasia 12: 269–281.CrossRefGoogle ScholarPubMed
Sarda, P, Lepage, G, Roy, CC and Chessex, P (1987). Storage of medium-chain triglycerides in adipose tissue of orally fed infants. American Journal of Clinical Nutrition 45: 399–405.CrossRefGoogle ScholarPubMed
Scharek, L and Tedin, K (2007). The porcine immune system – differences compared to man and mouse and possible consequences for infections by Salmonella serovars. Berliner und Münchener Tierärztliche Wochenschrift 115: 347–354.Google Scholar
Sheu, CW and Freese, E (1973). Lipopolysaccharide layer protection of Gram-negative bacteria against inhibition by long-chain fatty acids. Journal of Bacteriology 115: 869–875.CrossRefGoogle ScholarPubMed
Sheu, CW, Salomon, D, Simmons, JL, Sreevalsan, T and Freese, E (1975). Inhibitory effects of lipophilic acids and related compounds on bacteria and mammalian cells. Antimicrobial Agents and Chemotherapy 7: 349–363.CrossRefGoogle ScholarPubMed
Sidossis, LS, Stuart, CA, Shulman, GI, Lopaschuk, GD and Wolfe, RR (1996). Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. Journal of Clinical Investigation 98: 2244–2250.CrossRefGoogle ScholarPubMed
Solis De Los Santos, F, Donoghue, AM, Venkitanarayanan, K, Dirain, ML, Reyes-Herrera, I, Blore, PJ and Donoghue, DJ (2008). Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni colonization in ten-day-old broiler chickens. Poultry Science 87: 800–804.CrossRefGoogle ScholarPubMed
Solis De Los Santos, FS, Hume, M, Venkitanarayanan, K, Donoghue, AM, Hanning, I, Slavik, MF, Aguiar, VF, Metcalf, JH, Reyes-Herrera, I, Blore, PJ and Donoghue, DJ (2010). Caprylic acid reduces enteric campylobacter colonization in market-aged broiler chickens but does not appear to alter cecal microbial populations. Journal of Food Protection 73: 251–257.CrossRefGoogle Scholar
Sprong, RC, Hulstein, MF and Van der Meer, R (1999). High intake of milk fat inhibits intestinal colonization of Listeria but not of Salmonella in rats. Journal of Nutrition 129: 1382–1389.CrossRefGoogle Scholar
Sprong, RC, Hulstein, MFE and Van der Meer, R (2001). Bactericidal activities of milk lipids. Antimicrobial Agents and Chemotherapy 45: 1298–1301.CrossRefGoogle ScholarPubMed
Sun, CQ, O'Connor, CJ and Roberton, AM (2002). The antimicrobial properties of milkfat after partial hydrolysis by calf pregastric lipase. Chemico-Biological Interactions 140: 185–198.CrossRefGoogle ScholarPubMed
Symersky, T, Vu, MK, Frolich, M, Biemond, I and Masclee, AA (2002). The effect of equicaloric medium-chain and long-chain triglycerides on pancreas enzyme secretion. Clinical Physiology and Functional Imaging 22: 307–311.CrossRefGoogle ScholarPubMed
Takase, S and Goda, T (1990). Effects of medium-chain triglycerides on brush border membrane-bound enzyme activity in rat small intestine. Journal of Nutrition 120: 969–976.CrossRefGoogle ScholarPubMed
Tanaka, S, Saitoh, O, Tabata, K, Matsuse, R, Kojima, K, Sugi, K, Nakagawa, K, Kayazawa, M, Teranishi, T, Uchida, K, Hirata, I and Katsu, K (2001). Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. Journal of Gastroenterology and Hepatology 16: 748–754.CrossRefGoogle ScholarPubMed
Thormar, H, Isaacs, CE, Brown, HR, Barshatzky, MR and Pessolano, T (1987). Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrobial Agents and Chemotherapy 31: 27–31.CrossRefGoogle ScholarPubMed
Traul, KA, Driedger, A, Ingle, DL and Nakhasi, D (2000). Review of the toxicologic properties of medium-chain triglycerides. Food and Chemical Toxicology 38: 79–98.CrossRefGoogle ScholarPubMed
Tsuchido, T, Hiraoka, T, Takano, M and Shibasaki, I (1985). Involvement of autolysin in cellular lysis of Bacillus subtilis induced by short- and medium-chain fatty acids. Journal of Bacteriology 162: 42–46.CrossRefGoogle ScholarPubMed
Tsuzuki, Y, Miyazaki, J, Matsuzaki, K, Okada, Y, Hokari, R, Kawaguchi, A, Nagao, S, Itoh, K and Miura, S (2006). Differential modulation in the functions of intestinal dendritic cells by long- and medium-chain fatty acids. Journal of Gastroenterology 41: 209–216.CrossRefGoogle ScholarPubMed
Turner, N, Hariharan, K, Tidang, J, Frangioudakis, G, Beale, SM, Wright, LE, Zeng, XY, Leslie, SJ, Li, JY, Kraegen, EW, Cooney, GJ and Ye, JM (2009). Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids. Diabetes 58: 2547–2554.CrossRefGoogle ScholarPubMed
Valdivieso, V (1972). Absorption of medium-chain triglycerides in animals with pancreatic atrophy. American Journal of Digestive Diseases 17: 129–136.CrossRefGoogle ScholarPubMed
Van Dijk, AJ, Niewold, TA, Nabuurs, MJA, Hees, JV, Bot, PD, Stockhofe-Zurwieden, N, Ubbink-Blanksma, M and Beynen, AC (2002). Small intestinal morphology and disaccharidase activities in early-weaned piglets fed a diet containing spray-dried porcine plasma. Journal of Veterinary Medicine 49: 81–86.CrossRefGoogle ScholarPubMed
Van Immerseel, F, Buck, JD, Boyen, F, Bohez, L, Pasmans, F, Volf, J, Sevcik, M, Rychlik, I, Haesebrouck, F and Ducatelle, R (2004). Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis. Applied and Environmental Microbiology 70: 3582–3587.CrossRefGoogle ScholarPubMed
Van Kempen, TA and Odle, J (1993). Medium-chain fatty acid oxidation in colostrum-deprived newborn piglets: stimulative effect of L-carnitine supplementation. Journal of Nutrition 123: 1531–1537.CrossRefGoogle ScholarPubMed
Vessey, DA (2001). Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine. Digestive Diseases and Sciences 46: 438–442.CrossRefGoogle Scholar
Wang, J, Wu, X, Simonavicius, N, Tian, H and Ling, L (2006). Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. Journal of Biological Chemistry 281: 34457–34464.CrossRefGoogle ScholarPubMed
Witter, RC and Rook, JAF (1970). The influence of the amount and nature of dietary fat on milk fat composition in the sow. British Journal of Nutrition 24: 749–760.CrossRefGoogle ScholarPubMed
Wojtczak, L and Schönfeld, P (1993). Effect of fatty acids on energy coupling processes in mitochondria. Biochimica et Biophysica Acta 1183: 41–57.CrossRefGoogle ScholarPubMed
Woolford, MK (1975). Microbiological screening of the straight chain fatty acids (C1-C12) as potential silage additives. Journal of the Science of Food and Agriculture 26: 219–228.CrossRefGoogle ScholarPubMed
Young, FVK (1983). Palm kernel and coconut oils: analytical characteristics, process technology and uses. Journal of the American Oil Chemists’ Society 60: 374–379.CrossRefGoogle Scholar