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Mechanisms linking bovine viral diarrhea virus (BVDV) infection with infertility in cattle

Published online by Cambridge University Press:  09 September 2019

Chike F. Oguejiofor Open the ORCID record for Chike F. Oguejiofor [Opens in a new window] ,
Carole Thomas ,
Zhangrui Cheng  and
D. Claire Wathes
Chike F. Oguejiofor*
Affiliation:
Department of Veterinary Obstetrics and Reproductive Diseases, University of Nigeria, Nsukka410001, Nigeria Department of Pathobiology and Population Sciences, Royal Veterinary College, North Mymms, Hatfield, HertfordshireAL9 7TA, UK
Carole Thomas
Affiliation:
Department of Pathobiology and Population Sciences, Royal Veterinary College, North Mymms, Hatfield, HertfordshireAL9 7TA, UK
Zhangrui Cheng
Affiliation:
Department of Pathobiology and Population Sciences, Royal Veterinary College, North Mymms, Hatfield, HertfordshireAL9 7TA, UK
D. Claire Wathes
Affiliation:
Department of Pathobiology and Population Sciences, Royal Veterinary College, North Mymms, Hatfield, HertfordshireAL9 7TA, UK
*
Author for correspondence: Chike F. Oguejiofor, E-mail: [email protected]
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Abstract

Bovine viral diarrhea virus (BVDV) is an important infectious disease agent that causes significant reproductive and economic losses in the cattle industry worldwide. Although BVDV infection is known to cause poor fertility in cattle, a greater part of the underlying mechanisms particularly associated with early reproductive losses are not clearly understood. Previous studies reported viral compromise of reproductive function in infected bulls. In females, BVDV infection is thought to be capable of killing the oocyte, embryo or fetus directly, or to induce lesions that result in fetal abortion or malformation. BVDV infections may also induce immune dysfunction, and predispose cattle to other diseases that cause poor health and fertility. Other reports also suggested BVDV-induced disruption of the reproductive endocrine system, and a disruption of leukocyte and cytokine functions in the reproductive organs. More recent studies have provided evidence of viral-induced suppression of endometrial innate immunity that may predispose to uterine disease. Furthermore, there is new evidence that BVDV may potentially disrupt the maternal recognition of pregnancy or the immune protection of the conceptus. This review brings together the previous reports with the more recent findings, and attempts to explain some of the mechanisms linking this important virus to infertility in cattle.

Keywords

Bovine viral diarrhea virusimmunityinfertilitypregnancyreproduction
Type
Review Article
Information
Animal Health Research Reviews , Volume 20 , Issue 1 , June 2019 , pp. 72 - 85
Copyright
Copyright © Cambridge University Press 2019

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