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Variable Number of Tandem Repeats in Zygosity Diagnosis in Twins

Published online by Cambridge University Press:  01 August 2014

S. Costanzi Porrini ,
A. Sciarra ,
N. Sulli ,
M. Piane ,
R. Gualtieri  and
G. Del Porto
S. Costanzi Porrini
Affiliation:
Chair of Medical Genetics, University of Rome La Sapienza, Italy
A. Sciarra
Affiliation:
Fourth Chair of Clinical Medicine, University of Rome La Sapienza, Italy
N. Sulli
Affiliation:
Chair of Medical Genetics, University of Rome La Sapienza, Italy
M. Piane
Affiliation:
Chair of Medical Genetics, University of Rome La Sapienza, Italy
R. Gualtieri
Affiliation:
Fourth Chair of Clinical Medicine, University of Rome La Sapienza, Italy
G. Del Porto*
Affiliation:
Chair of Medical Genetics, University of Rome La Sapienza, Italy
*
Cattedra di Genetica Medica, Via Portuense 292, 00149 Rome, Italy

Abstract

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The use of DNA restriction fragment length polymorphisms (RFLP) to analyze variable number of tandem repeat (VNTR) sequences dispersed in the human genome, has become a powerful tool for the study of population genetics due to the very substantial polymorphism involved. Because the markers usually employed for twin zygosity determination (such as sex combination, placentation, HLA typing, blood group antigens, etc) may not be uniformly informative, we propose the use of synthetic olygonucleotides, representing VNTR “core” sequences, for the determination of zygosity in twins.

Keywords

Restriction fragment length polymorphismTwin zygosity
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 4 , October 1990 , pp. 473 - 477
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

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