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Utility of Genetic Markers in the Study of Human Resemblance

Published online by Cambridge University Press:  01 August 2014

W. J. Kimberling  and
D. E. Goldgar
W. J. Kimberling*
Affiliation:
Division of Medical Genetics, Boys Town Institute, Omaha, Nebraska Department of Otolaryngology, Creighton University Medical School, Omaha, Nebraska
D. E. Goldgar
Affiliation:
Division of Medical Genetics, Boys Town Institute, Omaha, Nebraska Department of Biometrics, University of Colorado Health Sciences Center, Denver, Colorado
*
Boys Town Institute, 555 North 30th Street, Omaha, NB, 68131, U.S.A.

Abstract

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A method for the estimation of genetic correlations based upon analysis of genetic marker phenotypes is presented. At a given marker locus, the probability of observing a pair of individuals with a specific combination of phenotypes can be expressed as a function of the gene frequencies at that locus and the genetic correlation (R) between that pair. The likelihood of obtaining a sample of n such pairs with their phenotypes at m marker loci can be expressed as a product of nm such functions. From the likelihood function, maximum likelihood estimates of R can be obtained, and hypotheses about R may be tested. A sample of Swedish twin families (61 dizygotic twin pairs, 268 husband-wife pairs, and 164 sib pairs) were analyzed by this method using information from 21 markers. It was found that for the twin pairs, R = 0.458, which was significantly different from the R calculated for sib pairs (R = 0.5 58) but not significantly different from the expected 0.5. For the husband-wife pairs, it was found that R = 0.086, which did differ significantly from the expected value of 0, indicating the presence of nonrandom mating in this population.

Keywords

Genetic markersTwin familiesHusband-wife correlationSib-sib correlationDizygotic twins correlation
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 4 , October 1980 , pp. 255 - 262
Copyright
Copyright © The International Society for Twin Studies 1980

References

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