Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-23T13:53:39.069Z Has data issue: false hasContentIssue false
  • English
  • Français

Utility of Genetic Markers in the Study of Human Resemblance

Published online by Cambridge University Press:  01 August 2014

W. J. Kimberling  and
D. E. Goldgar
W. J. Kimberling*
Affiliation:
Division of Medical Genetics, Boys Town Institute, Omaha, Nebraska Department of Otolaryngology, Creighton University Medical School, Omaha, Nebraska
D. E. Goldgar
Affiliation:
Division of Medical Genetics, Boys Town Institute, Omaha, Nebraska Department of Biometrics, University of Colorado Health Sciences Center, Denver, Colorado
*
Boys Town Institute, 555 North 30th Street, Omaha, NB, 68131, U.S.A.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A method for the estimation of genetic correlations based upon analysis of genetic marker phenotypes is presented. At a given marker locus, the probability of observing a pair of individuals with a specific combination of phenotypes can be expressed as a function of the gene frequencies at that locus and the genetic correlation (R) between that pair. The likelihood of obtaining a sample of n such pairs with their phenotypes at m marker loci can be expressed as a product of nm such functions. From the likelihood function, maximum likelihood estimates of R can be obtained, and hypotheses about R may be tested. A sample of Swedish twin families (61 dizygotic twin pairs, 268 husband-wife pairs, and 164 sib pairs) were analyzed by this method using information from 21 markers. It was found that for the twin pairs, R = 0.458, which was significantly different from the R calculated for sib pairs (R = 0.5 58) but not significantly different from the expected 0.5. For the husband-wife pairs, it was found that R = 0.086, which did differ significantly from the expected value of 0, indicating the presence of nonrandom mating in this population.

Keywords

Genetic markersTwin familiesHusband-wife correlationSib-sib correlationDizygotic twins correlation
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 29 , Issue 4 , October 1980 , pp. 255 - 262
Copyright
Copyright © The International Society for Twin Studies 1980

References

REFERENCES

1. Crumpacker, DW, Cederlof, R, Friberg, L, Kimberling, WJ, Sorenson, S, Vandenberg, SG, Williams, JS, McClearn, GE, Grever, B, Iyer, H, Krier, M, Pederson, NL, Price, RA, Roulette, I (1979. A twin methodology for the study of genetic and environmental control of variation in human smoking behavior. Acta Genet Med Gemmellol 28:173–195.Google Scholar
2. Gill, , Murray, , Pitfield, (1972): The implementation of two revised quasi-newton algorithms for unconstrained optimization. National Physical Laboratory Report DNAC 11.Google Scholar
3. Goldgar, DE (1981): Statistical methodology for the partitioning of the genetic variance of a quantitative character to specific chromosomes. Unpublished doctoral dissertation, University of Colorado.Google Scholar
4. Morton, NE (1955. Sequential tests for the detection of linkage. Am J Hum Genet 7:277–318.Google ScholarPubMed
5. Morton, NE (1956. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet 8:80–96.Google ScholarPubMed
6. Risch, N, Lange, K (1979. Application of a recombination model in calculating the variance of sib pair identity. Ann Hum Genet 43:177–186.Google Scholar