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Twin Study on Myopia

Published online by Cambridge University Press:  01 August 2014

L.L.-K. Lin  and
C.-J. Chen
L.L.-K. Lin*
Affiliation:
Departments of Ophthalmology and Public Health, National Taiwan University, Taipei
C.-J. Chen
Affiliation:
Departments of Ophthalmology and Public Health, National Taiwan University, Taipei
*
Department of Ophthalmology, National Taiwan University Hospital, 1 Chang-Te Street, Taipei, Taiwan

Abstract

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In order to reassess the relative importance of genetic and environmental factors in the development of myopia in Chinese schoolchildren, 90 pairs of MZ and 36 pairs of like-sex DZ twins were enrolled for detailed ophthalmological examination about their ocular refractions. Corneal curvatures and axial lengths were also measured. With equivalent settings of the range for concordance, corneal curvatures showed higher concordance rate (84%) than ocular refractions (65%) and axial lenghts (59%) in MZ twins. F-test on the intrapair variances between MZ and DZ twins revealed a significant hereditary role in determining the ocular refraction and its optical components. The degree of genetic determination was expressed by heritability indices, which were derived from intraclass correlation coefficients. The diversity of sample ages and refractions, while making the obtained data difficult to further explore the gene-environment interaction, led to the observation of more intrapair differences with age and myopic progression in MZ twins.

Keywords

MyopiaHeritabilityTwin concordance
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 36 , Issue 4 , October 1987 , pp. 535 - 540
Copyright
Copyright © The International Society for Twin Studies 1987

References

REFERENCES

1. Chen, CJ, Cohen, BH, Diamond, EL (1985): Genetic and environmental effects on the development of myopia in Chinese twin children. Ophthal Paediatr Genet 6:113–119.Google Scholar
2. Chen, CJ, Lin, LK, Hung PT (1986): Nation-wide survey of myopia in Taiwan: a preliminary report. Presented at the Third International Conference on Myopia, Rome.Google Scholar
3. Lai, CY, Huang, WL, Sheu, MM, Chen, CW (1983): Refractive status of students in Kaohsiung Medical College. Trans Soc Ophthal Sin 22:14–20.Google Scholar
4. Lin, LK (1985): Epidemiological Study on Myopia Among Schoolchildren in Taiwan. Doctorate thesis. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University.Google Scholar
5. Lin, LK, Hung, LF, Shih, YF, Hung, PT, Ko, LS (1986): Correlation of optical components with ocular refraction among teenagers in Taipei. Presented at the Third International Conference on Myopia, Rome.Google Scholar
6. Schwartz, JT (1968): Twin studies in ophthalmology. Am J Ophthalmol 66:323–327.Google Scholar
7. Shih, YF, Wang, AH, Ko, LS (1984): The refractive status of clerks in College of Medicine, National Taiwan University. Presented at the 25th annual meeting of the Ophthalmological Society of R.O.C., Taipei.Google Scholar
8. Sorsby, A, Sheridan, M, Leary, GA (1962): Refraction and its components in twins. Medical Research Council Special Report Series N 303. London: HMSO.Google Scholar
9. Sorsby, A (1982): Biology of the eye asan optical system. In Duane, (ed): Clinical Ophthalmology, Vol 1, Chapter 34 New York: Harper & Row.Google Scholar