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Twin Azygotic Test for the Study of Hereditary Qualitative Traits in Twin Populations

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
C. Rossi  and
G. Brenci
L. Gedda*
Affiliation:
The Mendel Institute, Rome
C. Rossi
Affiliation:
Institute of Probability Calculus, University of Rome
G. Brenci
Affiliation:
The Mendel Institute, Rome
*
The Mendel Institute, Piazza Galeno 5, 00161 Rome, Italy

Abstract

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Following previous formulations of a model of qualitative analysis of twin population data independent of zygosity, a new Bayesian approach has been developed. The present model can be applied to any qualitative genetic trait in twin population data, provided no specific source of variation be introduced by the twin condition, and allows not only estimation of the frequencies of mono- and dizygosity as well as the gene frequencies, but also verification of the trait's mode of inheritance.

Keywords

Azygotic testBayesian modelDemographic dataMode of inheritanceGene frequencyQualitative analysisTwinsZygosity determination
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 28 , Issue 1 , January 1979 , pp. 15 - 19
Copyright
Copyright © The International Society for Twin Studies 1979

References

REFERENCES

1.Allen, G (1955): Comments on the analysis of twin samples. Acta Genet Med Gemellol 4:143–160.Google Scholar
2.Allen, G, Hrubec, Z (1979). Twin concordance: A more general model. Acta Genet Med Gemellol 28:3–13.Google ScholarPubMed
3.Gedda, L, Brenci, G (1962). Proposta del test gemellare azigotico. Acta Genet Med Gemellol 11:1–8.Google Scholar
4.Gedda, L, Brenci, G (1966): Theoretical models in twin research. Acta Genet Med Gemellol 15: 219–223.CrossRefGoogle Scholar
5.Gedda, L, Brenci, G, Rossi, C (1978): Twin models in population genetics. In Nance, WE, Allen, G, Parisi, P (eds): “Twin Research, Part B: Biology and Epidemiology.” Proceedings of the Second International Congress on Twin Studies, Washington 1977. New York: Alan R Liss, pp 149–152.Google Scholar
6.Lindley, DV (1971): The estimation of many parameters. In Godambe, VP, Sprott, DA (eds): “Foundations of Statistical Inference.” New York: Holt, Rinehart & Winston.Google Scholar
7.Lindley, DV (1971). Bayesian statistics: A review. SIAM, Regional Conference Series in Applied Mathematics.Google Scholar
8.O'Hagan, A (1976). On posterior joint and marginal modes. Biometrika 63:329–333.Google Scholar
9.Selvin, S (1970). Concordance in a twin population model. Acta Genet Med Gemellol 19:584–590.CrossRefGoogle Scholar
10.Stern, K (1958). The ratio of monozygotic to dizygotic affected twins and the frequencies of affected twins in unselected data. Acta Genet Med Gemellol 7:313–320.Google Scholar