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Tre Coppie di Gemelle in Tre Generazioni Successive Nate da Madri Gemelle

Published online by Cambridge University Press:  01 August 2014

G. Andreano ,
M. Dobosz ,
I. Boschi ,
L. E. Ruscitti ,
A. Liberti  and
D. Casa
G. Andreano*
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
M. Dobosz
Affiliation:
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore di Roma
I. Boschi
Affiliation:
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore di Roma
L. E. Ruscitti
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
A. Liberti
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
D. Casa
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
*
c/o Servizio di Genetica Medica (, Primario: Prof. D. Casa), Dipartimento di Medicina Sperimentale, Policlinico Umberto I, Università degli Studi di Roma “La Sapienza”, Viale Regina Elena 324, 00161 Roma

Abstract

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It is generally held that there are genetic factors for dizygotic (DZ) twinning, but the pattern of inheritance is far from clear.

We report on a rare pedigree with three sets of spontaneous DZ female twin births in three successive generations. To our knowledge no similar pedigrees have been reported in literature.

Zygosity determination in three pairs of twins was performed with ABO, MN and Rh blood groups from erythrocytes and with STR analysys from samples of saliva.

In our pedigree, the direct trasmission of the DZ twinning through the maternal line seems show an autosomal dominant pattern of inheritance. We believe that the inheritance of DZ twinning appears to be recessive in most case and autosomal dominant only in rare instances. It is plausible with the hypothesis that the expression of the dizygotic twinning trait in a mother shows a genetic heterogeneity.

Keywords

TwinsDizygotic twinningZygosity determinationSTR analysisPedigree studyAutosomal dominant
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 47 , Issue 1 , January 1998 , pp. 43 - 49
Copyright
Copyright © The International Society for Twin Studies 1998

References

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