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A Study of Multiple Biological Markers in Twins

Published online by Cambridge University Press:  01 August 2014

H. Anton-Guirgis ,
B.D. Culver ,
T. Kurosaki  and
R. Elston
H. Anton-Guirgis*
Affiliation:
Department of Community & Environmental Medicine, University of California, Irvine
B.D. Culver
Affiliation:
Department of Community & Environmental Medicine, University of California, Irvine
T. Kurosaki
Affiliation:
Department of Community & Environmental Medicine, University of California, Irvine
R. Elston
Affiliation:
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans
*
Department of Community and Environmental Medicine, University of California, Irvine, CA 92717, USA

Abstract

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Genetic and environmental influences on the phenotypic expressions of several biological markers were studied in 18 monozygous (MZ) and 8 dizygous (DZ)twin pairs. Zygosity was determined using ABO, Rh, and HLA. The biomarkers studied included: T & B lymphocytes, suppressor and helper T lymphocytes (Tγ , Tμ ), T cell (PHA) mitogen activation (MA), serum immunoglobulins (IgA, IgM, and IgG), plasma carcinoembryonic antigen (CEA), aryl-hydrocarbon hydroxylase (AHH) and sister chromatid exchange (SCE) in lymphocytes. Temporal variation of markers over a 6-month period was not significant. The mean absolute differences between levels from first and second blood draws were less than one standard deviation. Variability associated with age was not significant. Females had higher levels of T lymphocytes than males. A gender related association was observed for the IgM immunoglobulin test: females had a higher mean level of IgM. Smoking was found to influence the levels of SCE, T helper lymphocytes and mitogen activation. The variability of these biomarkers within and between twin pairs was quantified. Immunoglobulin levels, particularly that of IgM, showed statistically greater similarity within MZ twins than within DZ twins. Several other markers suggested heritability.

Keywords

CancerT & B lymphocytesMitogen activationSerum immunoglobulinsPlasma carcinoembryonic antigenAryl-hydrocarbon hydroxylaseSister Chromatid Exchange
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 3-4 , October 1985 , pp. 153 - 165
Copyright
Copyright © The International Society for Twin Studies 1985

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