Hostname: page-component-68945f75b7-mktnf Total loading time: 0 Render date: 2024-09-03T21:48:35.118Z Has data issue: false hasContentIssue false
  • English
  • Français

Strain and Sex Differences in Gastric Ulceration in Restrained Rats

Published online by Cambridge University Press:  01 August 2014

T. R. Wilson
T. R. Wilson*
Affiliation:
Dept. of Pharmacology, University Medical School, Manchester (Great Britain)

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Male and female rats of three different strains were subjected to physical restraint, when it was demonstrated that there is a relationship between the strain of the rat and its susceptibility to gastric ulcer formation. Severity of ulceration was greatest in Wistar rats. Hooded Wistar rats were also ulcer-susceptible, but not to such a great extent as Wistar animals. Sprague-Dawley rats were resistant to ulcer formation. Sex differences in ulcer severity were found only with restrained Hooded Wistar rats.

The results of this investigation compare favourably with results published for individual strains of rats by other workers. It is possible that genetic influences may be responsible for the differences observed, but the way in which they operate is not understood.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 16 , Issue 3 , July 1967 , pp. 310 - 316
Copyright
Copyright © The International Society for Twin Studies 1967

References

Aagaard, P. (1963). Studies of Gastric Ulcer. M. D. Thesis, Copenhagen.Google Scholar
Ader, R. et al. (1960 a). Social factors affecting emotionality and resistance to stress in animals. I. – Age of separation from the mother and susceptibility to gastric ulcer in the rat. J. Comp. Physiol. Psychol., 53: 446–454.CrossRefGoogle Scholar
Ader, R. et al. (1960 b). Social factors affecting emotionality and resistance to disease in animals. II – Suceptibility to gastric ulceration as a function of interruptions in social interactions and the time at which they occur. J. Comp. Physiol. Psychol., 53: 455–458.CrossRefGoogle Scholar
Ader, R. et al. (1960 c).Blood pepsinogen and gastric erosions in the rat. Psychosom. Med., 22: 1–12.CrossRefGoogle ScholarPubMed
Beeson, P. B., MacDermott, W. (Eds.) (1963). Cecil-Loeb Textbook of Medicine, 11th Ed., W. B. Saunders Company, Philadelphia.Google Scholar
Bonetti, E. P., Wilson, C. W. M. (1964). Assessment of gastric damage in the rat. Brit. J. Pharmacol., 23: 221. (Demonstration).Google Scholar
Bonfils, S. et al. (1957). L'ulcère de contrainte du rat blanc. Modifications de la fréquence lesionnelle par différents procédés opératoires et pharmacodynamiques. C. R. Soc. Biol. Paris., 151: 1149–1150.Google Scholar
Bonfils, S. et al. (1959 a). Ulcère expérimental de contrainte du rat blanc. I. Méthodes, fréquence des lésions. Modifications par certains procédés techniques et pharmacodynamiques. Rev. Franç. Etud. Clin. Biol., 4: 146–150.Google Scholar
Bonfils, S. et al. (1959 b). Ulcère expérimental du contrainte du rat blanc. II. Anatomopathologie des lésions gastriques et de différentes lésions viscérales. Evolution des lésions après cessation de la contrainte. Rev. Franç. Etud. Clin. Biol., 4: 888–894.Google Scholar
Bonfils, S. et al. (1959 c). L'ulcère expérimental de contrainte du rat blanc. Analyse des principaux facteurs determinants. Arch. Mal. App. Digest., 47: 449–459.Google Scholar
Bonfils, S., Lambling, A. (1963). Psychological factors and psychopharmacological actions in the restraint-induced gastric ulcer. In: Pathophysiology of Peptic Ulcer. Ed. Skoryna, S., Montreal, McGill Univ. press.Google Scholar
British Medical Journal (1965). Stress and Gastro-intestinal Haemorrhage. (Leading article). Brit. Med. J., 1: 1140.CrossRefGoogle Scholar
Broadhurst, P. L. (1964). The hereditary base for the action of drugs on animal behaviour. In: Ciba Foundation Symposium on Animal Behaviour and Drug Action. Churchill, London.Google Scholar
Brodie, D. A., Hanson, H. M. (1960). A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology, 37: 353–360.CrossRefGoogle Scholar
Cleave, T. L. (1962). Peptic Ulcer. John Wright & Sons, Ltd., Bristol.Google Scholar
Grant, E. C., Chance, M. R. A. (1958). Rank order in caged rats. Anim. Behav., 6: 183–194.CrossRefGoogle Scholar
Hanson, H. M., Brodie, D. A. (1960). Use of restrained rat technique for the study of the anti-ulcer effect of drugs. J. Appl. Physiol., 15: 291–294.CrossRefGoogle Scholar
Martindale, K. et al. (1960). The effect of thalidomide in experimental gastric ulceration. J. Pharm. Pharmacol. (Suppl.), 12: 153T–158T.CrossRefGoogle Scholar
Rossi, G. et al. (1956). Technique nouvelle pour produire des ulcérations gastriques chez le rat blanc: l'ulcère de contrainte. C. R. Soc. Biol. Paris., 150: 2124–2126.Google Scholar
Sawrey, W. L., Long, D. H. (1962). Strain and sex differences in ulceration in the rat. J. Comp. Physiol. Psychol., 55: 603–605.CrossRefGoogle ScholarPubMed
Sines, J. O. (1959). Selective breeding for development of stomach lesions following stress in the rat. J. Comp. Physiol. Psychol., 52: 615–617.CrossRefGoogle ScholarPubMed
Wilson, T. R. (1964). Experimental gastric ulceration in the rat. Ph. D. Thesis., University of Liverpool.Google Scholar
Wilson, T. R. (1966 a). Experimental gastric ulceration in the rat. An examination of three variables. Submitted to Gastroenterologia.Google Scholar
Wilson, T. R. (1966 b). Age and susceptibility to gastric ulceration in male and female rats. Gerontologia, 12: 226–230.CrossRefGoogle ScholarPubMed