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Retinoblastoma in two single-born sisters and two MZ female twins in the same sibship

Published online by Cambridge University Press:  02 February 2016

L. Gedda  and
A. Alfieri
L. Gedda
Affiliation:
Cattedra di Genetica Medica dell'Università di Roma, presso l'lstituto di Genetica Medica e Gemellologia « G. Mendel »
A. Alfieri
Affiliation:
Cattedra di Genetica Medica dell'Università di Roma, presso l'lstituto di Genetica Medica e Gemellologia « G. Mendel »

Summary

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A sibship is reported, including four female children, two of which MZ twins, all affected by retinoblastoma (the lesion being bilateral in three of them, and unilateral in a fourth one). The literature on the heredity of the condition is considered; the latter does not appear to be inherited as a regular dominant. Finally its genetic interpretation in the observed sibship is considered.

Riassunto

Riassunto

Gli AA. riportano il caso di una fratria comprendente 4 bambine, delle quali due gemelle MZ, tutte affette da retinoblastoma (tre con lesione bilaterale e una con lesione monolaterale).

Vengono considerati i dati riportati nella letteratura sulla ereditarietà della malattia, che non si manifesta secondo gli schemi di una dominanza regolare, e viene discussa l'interpretazione genetica nella fratria osservata.

Résumé

RÉSUMÉ

Les AA. rapportent le cas d'une fratrie comprenant quatre filles, dont deux jumelles MZ, toutes atteintes de rétinoblastome (la lésion étant bilatérale en trois cas, et monolatérale dans un quatrième). Les AA. considèrent la bibliographie sur l'hérédité de la maladie, qui ne paraît pas se transmettre suivant une dominance regulière, et en discutent l'interprétation génétique dans la fratrie observée.

Zusammenfassung

ZUSAMMENFASSUNG

Verf. bringen den Fall einer Sippe, in der 4 Mädchen, darunter ein EZ-Paar, an einem Retinoblastom leiden (die Läsion war in drei Fällen bilateral, in einem Falle monolateral). Es folgt eine Betrachtung der in der Literatur angeführten Daten über die Vererbung der Krankheit, die nicht den Schemen der regelmässigen Dominanz folgend auftritt, weshalb die genetische Ausdeutung der Sippenbeobachtung zu erörtern bleibt.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 15 , Issue 2 , April 1966 , pp. 178 - 189
Copyright
Copyright © The International Society for Twin Studies 1966

References

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