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President's Address: Twinning in Families of Triplets

Published online by Cambridge University Press:  01 August 2014

A.W. Eriksson
A.W. Eriksson*
Affiliation:
Institute of Human Genetics, Free University of Amsterdam, The Netherlands, and Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland
*
Institute of Human Genetics, Medical Faculty, Free University, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands

Abstract

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A study was conducted on twinning in relatives of consecutive triplet sets in the Åland Islands in the years 1740-1939. The incidence of twinning in sibships of triplets was extremely high, 80/1000 (56/1000 before and 143/1000 after the triplet maternity). In Finland as a whole, 1905-1954, the twinning rate was among mothers of triplets 38/1000, ie, about 2.6 times the rate in general population, and was higher after (48/1000) than before the triplet maternity (34/1000). In the sibships of fathers of triplets there was a low rate of twinning (below 10/1000) both of same-sexed (SS) and of opposite-sexed (OS) triplets. Among sibships of mothers of OS triplets the twinning rate was 18/1000 and among mothers' sibships of SS triplets 26/1000. The series of triplet families from both Åland and Finland as a whole indicate a considerably higher frequency of twinning on the maternal than on the paternal side. The sibships of OS triplets in Finland have higher twinning rates than sibships of SS triplets (50/1000 vs 27/1000). In sibships of triplets, not only the DZ but also the MZ twinning rates were approximately twice as high as those in the general population. The triplet rates in Finland were increasing strongly with maternal age and were in the last century among mothers of 30-39 years of age considerably higher than among mothers from this century. This, in combination with higher mean parity, may explain the high rates of multiple maternities in sibships of triplets in the past. The rate of triplet maternities seems to be more sensitive to sociodemographic changes than the rate of twin maternities. Mothers of triplets in Finland had a high frequency (more than 40%) of prenuptially conceived firstborn children. This, and a short protogenesic interval indicate that triplet-prone mothers are more fecundable, ie, they conceive with greater ease and/or may have a better physical condition than other women for completing a gestation with multiple embryos.

Keywords

FecundityInheritance of multiple maternitiesTripletsTwinningÅland IslandsFinland
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 3 , July 1990 , pp. 279 - 293
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

1.Allen, G (1960): A differential method for estimation of type frequencies in triplets and quadruplets. Am J Hum Genet 12:210–224.Google Scholar
2.Allen, G (1988): Frequency of triplet zygosity types among U.S. births, 1964. Acta Genet Med Gemellol 37:299–306.Google ScholarPubMed
3.Berg, G, Finnström, O, Selbing, A (1983): Triplet pregnancies in Linköping, Sweden, 1973-1981. Acta Genet Med Gemellol 32:251–256.Google Scholar
4.Boklage, CE (1987): The organization of the oocyte and embryogenesis in twinning and fusion malformations. Acta Genet Med Gemellol 36:241–431.Google ScholarPubMed
5.Bulmer, MG (1958): The repeat frequency of twinning. Ann Hum Genet 23:31–35.Google Scholar
6.Bulmer, MG (1958): The number of multiple births. Ann Hum Genet 22:158–164.CrossRefGoogle ScholarPubMed
7.Bulmer, MG (1960): The familial incidence of twinning. Ann Hum Genet 24:1–3.Google Scholar
8.Bulmer, MG (1970): The Biology of Twinning in Man. Oxford & London: Oxford Univ Press.Google Scholar
9.Curtius, F, von Verschuer, O (1932): Die Anlage zur Entstehung von Zwillingen und ihre Vererbung. Arch Rassembiol 26:361–387.Google Scholar
10.Dahlberg, G (1926): Twin Births and Twins from a Hereditary Point of View. Stockholm: Thesis Univ Uppsala, pp 29.Google Scholar
11.Dahlberg, G (1952): Die Tendenz zu Zwillingsgeburten. Acta Genet Med Gemellol 1:80–87.CrossRefGoogle Scholar
12.Davenport, CB (1920): Influence of the male in the production of human twins. Amer Naturalist 54:122–129.Google Scholar
13.Davenport, CB (1928): Is there inheritance of twinning tendency from the father's side?Verh. 5 Int Kongr Vererb Berlin. Ed. by Nachtscheim, H. Bornträger Leipzig 1928: 1:595–602. Z In-dukt Abstamm Vererb Suppl 46:85-86.Google Scholar
14.Elwood, JM (1985): Temporal trends in twinning. In Kalto, H (ed): Issues and Reviews in Teratology. London: Plenum Press, 3: pp 65–93.CrossRefGoogle Scholar
15.Eriksson, AW (1964): Pituitary gonadotrophin and dizygotic twinning. Lancet 2:1298–1299.CrossRefGoogle ScholarPubMed
16.Eriksson, AW (1973): Human Twinning in and around the Åland Islands. Thesis Univ. Helsinki. Comment Biol. Suppl 64, pp. 159.Google Scholar
17.Eriksson, AW, Fellman, J (1967): Twinning and legitimacy. Hereditas 57:395–402.Google Scholar
18.Eriksson, AW, Fellman, J (1967): Twinning in relation to the marital status of the mother. Acta Genet 17:385–398.Google Scholar
19.Fellman, JO, Eriksson, AW (1990): A mathematical model for recurrent twinning. Acta Genet Med Gemellol 39:307–316.Google ScholarPubMed
20.Fisher, RA (1928): Triplet children in Great Britain and Ireland. Proc Roy Soc Ser B 102:286–311.Google Scholar
21.Gedda, L (1951): Studio dei Gemelli. Roma: Edizioni Orizzonte Medico, pp. 1381.Google Scholar
22.Gedda, L, Brenci, G (1965): Human monozygotic and plurizygotic multiple births: Heredity and hormone action. Acta Genet Med Gemellol 14:109–131.Google Scholar
23.Harvey, MA, Michael, R, Huntley, C, Smith, DW (1977): Familial monozygotic twinning. J Pediatr 90:246–248.Google Scholar
24.Lillyn, ET, Gindilis, VM (1976): Genetico-statistical analysis of multiple births in humans. I. Genetic analysis of the tendency to multiple births (in Russian with English summary). Genetika 12:118–127.Google Scholar
25.Michels, VV, Riccardi, VM (1978): Twin recurrence and amniocentesis: Male and MZ heritability factors. Birth Defects Orig Art Ser 14/6A:201–211.Google Scholar
26.Miettinen, M (1954): On triplets and quadruplets in Finland. Thesis Univ Turku. Acta Paediat 43, Suppl 97:1–103.CrossRefGoogle Scholar
27.Miettinen, M, Grönroos, JA (1965): A follow-up study of Finnish triplets. Ann Paediat Fenn 11:71–83.Google ScholarPubMed
28.Parisi, P, Gatti, M, Prinzi, G, Caperna, G (1983): Familial incidence of twinning. Nature 304:626–628.CrossRefGoogle ScholarPubMed
29.Pitkänen, K (1984): The educated people: the precursors of the fertility transition in Finland. Scand Population Studies 62:15–32.Google Scholar
30.Ron-El, R, Caspi, E, Schreyer, P, Weinraub, Z, Arieli, S, Goldberg, M (1981): Triplet and quadruplet pregnancies and management. Obstet Gynecol 57:458–463.Google Scholar
31.Shapiro, LR, Zemek, L, Shulman, MJ (1978): Genetic etiology for monozygotic twinning. Birth Defects Orig Art Ser 14/6A:219–222.Google Scholar
32.Weinberg, W (1901): Beiträge zur Physiologie und Pathologie der Mehrlingsgeburten beim Menschen. Arch Ges Physiol 88:346–430.CrossRefGoogle Scholar
33.Weinberg, W (1909): Die Anlage zur Mehrlingsgeburt beim Menschen und ihre Vererbung. Arch Rassenbiol 322–339, 470–482, 609–630.Google Scholar