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Placental Forms and Zygosity Determination of Twins in Ibadan, Western Nigeria A study of 1475 twin maternities

Published online by Cambridge University Press:  01 August 2014

P. P. S. Nylander
P. P. S. Nylander*
Affiliation:
Dept. of Obstetrics and Gynaecology, University of Ibadan, Nigeria
*
Dept. of Obstetrics and Gynaecology, University of Ibadan, Nigeria

Extract

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The incidence of twinning in Western Nigeria is very high, being 45‰ (Nylander, 1969a), as compared with 11-12‰ in Caucasian populations (Registrar General, 1967). A recent study of twinning in Ibadan, in which zygosity of individual twin pairs was determined, has shown that the pattern of placentation and zygosity in this population is also very different from that in Caucasian populations.

As many as 1475 consecutive newborn twin pairs delivered in three hospitals in Ibadan between March 1967 and April 1969 were investigated.

The placentae of the twins were examined macroscopically by the author personally to determine the form (whether single, fused, double or separate) and the membrane relationships (whether monochorionic or dichorionic) as shown in Figs. 1 and 2. The membrane relationship was confirmed by histological examination.

Cord blood samples were collected from each twin pair and studied for (1) ABO, Rh (using antisera, C, c, D, E, e), MNSs and Gonzales blood groups and (2) G6PD electrophoretic pattern. Other blood groups like Fya, k and Jk, used initially, were discontinued later, because the gene frequencies in this population are such that they are uninformative for zygosity determination.

Samples of the placenta of each twin were sent in refrigerated containers to the Galton Laboratory, London University, for placental enzyme studies — phosphoglucomutase and peptidase (Hopkinson and Harris, 1968; Lewis and Harris, 1967).

Type
Session 4 - Zygosity Determination
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 1-2 , April 1970 , pp. 49 - 54
Copyright
Copyright © The International Society for Twin Studies 1970

References

Cameron, A. H. (1968). The Birmingham Twin Survey. Proc. Roy. Soc. Med., 61: 229.CrossRefGoogle ScholarPubMed
Edward, J. H., Cameron, A. H., Wingham, J. (1967). In Strong, S. J. and Corney, G.: The Placenta in Twin Pregnancy. Pergamon Press, Oxford.Google Scholar
Hopkinson, D. A., Harris, H. (1968). Ann. Hum. Genet., 31: 359.CrossRefGoogle Scholar
Lewis, W. H. P., Harris, H. (1967). Nature (London), 215: 351.Google Scholar
Nylander, P. P. S. (1969 a). The frequency of twinning in a rural community in Western Nigeria. Ann. Hum. Genet., 33: 41.CrossRefGoogle Scholar
Nylander, P. P. S. (1969 b). The value of the placenta in the determination of zygosity. A study of 1052 Nigerian twin maternities. J. Obstet. Gynaec. Brit. Comm., 76: 699.Google Scholar
Nylander, P. P. S. (1970). J. Obstet. Gynaec. Brit. Comm. (Inpress).Google Scholar
Potter, E. L. (1963). Twin zygosity and placental form in relation to the outcome of pregnancy. Amer. J. Obstet. Gynec, 87: 566.Google Scholar
Registrar General (1967). Statistical Review of England and Wales for the year 1965.Google Scholar
Shipley, P. W., Wray, J. A., Hechter, H. H., Arellano, M. G., Borhani, N. O. (1967). Frequency of twinning in California: its relationship to maternal age, parity and race. Amer. J. Epidem., 85: 147.Google Scholar
Strong, S. J., Corney, G. (1967). The Placenta in Twin Pregnancy. Pergamon Press, Oxford.Google Scholar
Weinberg, W. (1902). Beiträge zur Physiologie und Pathologie der Mehrlingsgeburten beim Menschen. Pflüger. Arch. Ges. Physiol., 88: 346.Google Scholar